Inhibitors of glycosphingolipid synthesis and methods of use
Compositions in the prevention and treatment of skin diseases or associated disorders, inflammation or inflammatory diseases or disorders, include at least one inhibitor of glycosphingolipid synthesis.
1 . A method of treating hair loss or alopecia comprising:
orally or topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of an encapsulated inhibitor of glycosphingolipid synthesis inhibitor,
wherein the glycosphingolipid synthesis inhibitor is D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP);
wherein the D-PDMP is encapsulated in a polyethylene glycol-sebacic acid polymer; and wherein the effective amount is a dose amount of 1 mg to 10 mg of D-PDMP per kg of subject body weight.
2 . The method of claim 1 , wherein the composition is administered topically in the form of a cream, gel, ointment, spray, balm, emulsion, liposome, liquid crystal preparation, lotion, or any combination thereof.
3 . The method of claim 1 , wherein the composition is administered topically, and the composition further comprises one or more lipids comprising fatty acids, free fatty acids, cholesterol, sterol esters, triglycerides, diglycerides, glycerides, wax esters, squalene, ceramides, phospholipids, glycolipids, linoleic acids or combinations thereof.
4 . The method of claim 3 , wherein the composition comprises ceramide to lipid ratios from about 1:1 to 10:1.
5 . A method of treating hair discoloration comprising:
orally or topically administering to a subject in need thereof a composition comprising a therapeutically effective amount of an encapsulated inhibitor of glycosphingolipid synthesis inhibitor,
wherein the glycosphingolipid synthesis inhibitor is D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP);
wherein the D-PDMP is encapsulated in a polyethylene glycol-sebacic acid polymer; and wherein the effective amount is a dose amount of 1 mg to 10 mg of D-PDMP per kg of subject body weight.
6 . The method of claim 5 , wherein the composition is administered topically in the form of a cream, gel, ointment, spray, balm, emulsion, liposome, liquid crystal preparation, lotion, or any combination thereof.
7 . The method of claim 5 , wherein the composition is administered topically, and the composition further comprises one or more lipids comprising fatty acids, free fatty acids, cholesterol, sterol esters, triglycerides, diglycerides, glycerides, wax esters, squalene, ceramides, phospholipids, glycolipids, linoleic acids or combinations thereof.
8 . The method of claim 7 , wherein the composition comprises ceramide to lipid ratios from about 1:1 to at least 10:1.