Use of
The present invention discloses use of Streptococcus thermophilus ST7 for modulating immunity, comprising using the Streptococcus thermophilus ST7 as an active ingredient for modulating immunity, wherein the Streptococcus thermophilus ST7 are deposited under the accession Nos. BCRC911126 and DSM34255. By administering an effective dose of Streptococcus thermophilus ST7 to an individual, the expression level of IL-12p40 on cells can be increased, the gut microbiota can be modulated and the Firmicutes/Bacteroidetes ratio in the intestine increases to improve immunity and antiviral ability.
1 . A method for modulating immunity in an individual, comprising administering Streptococcus thermophilus ST7, wherein the Streptococcus thermophilus ST7 is an active ingredient that modulates immunity, wherein the Streptococcus thermophilus ST7 is deposited at the German Collection of Microorganisms and Cell cultures under accession no. DSM34255, wherein the modulating immunity is increasing the expression level of IL12p40 in cells to between 400 and 1000 μg/mL, increasing the ratio of Firmicutes to Bacteroidetes in the intestinal microbiota, alleviating intestinal injury caused by viruses and enhancing antiviral immunity, increasing the activation of CD4 + T cells and CD8 + T cells during viral infection, or inducing the expression of IFN-γ in the CD4+ T cells and CD8+ T cells.
2 . The method according to claim 1 , wherein the Streptococcus thermophilus ST7 is an inactivated bacterium.
3 . The method according to claim 1 , wherein no other strains of bacteria besides Streptococcus thermophilus ST7 are administered.
4 . The method according to claim 1 , wherein the Streptococcus thermophilus ST7 is administered at a dose of 1×10 6 to 1×10 10 CFU/day.