Traditional CHINESE medicine compound composition with immune bidirectional regulation effect and preparation method and applications thereof
A traditional Chinese medicine compound composition with immune bidirectional regulation effect and its preparation method and applications are disclosed. The traditional Chinese medicine compound composition with immune bidirectional regulation effect is prepared by compounding a volatile oil obtained after heating and refluxing of Schizonepetae herba and an extract jointly extracted by Schizonepetae herba extract residue, Astragali radix and Atractylodes macrocephala in the disclosure. The traditional Chinese medicine compound composition has no side effects and remarkable effect, and the traditional Chinese medicine compound composition disclosed by the disclosure can be used as a dietary supplement or health food raw material to regulate allergic reaction and low immunity. The traditional Chinese medicine compound composition disclosed by the disclosure is suitable for promotion and application.
1 . A traditional Chinese medicine compound composition with immune bidirectional regulation effect, wherein the traditional Chinese medicine compound composition is prepared by compounding a volatile oil and an extract, wherein;
(i) the volatile oil is obtained after heating and refluxing of Schizonepetae herba with purified water, which a volume ratio of the Schizonepetae herba to purified water is 1: (5-20);
(ii) the extract is obtained by jointly extracted by Schizonepetae herba extract residue from step (i), Astragali radix and Atractylodes macrocephala , with purified water, which a volume ratio of purified water to a total volume of the Schizonepetae herba extract residue, the Astragali radix and the Atractylodes macrocephala is (6-8): 1; and
(iii) the traditional Chinese medicine compound composition consists of:
1-100 parts by weight of Schizonepetae herba,
1-300 parts by weight of Astragali radix ; and
1-150 parts by weight of Atractylodes macrocephala.
2 . The traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 1 , wherein an optimal ratio of the Schizonepetae herba , the Astragali radix , and the Atractylodes macrocephala in the traditional Chinese medicine compound composition is (1-2): (3-5): (1-2).
3 . A composition comprising the traditional Chinese medicine compound composition of claim 1 , wherein the composition is in the form of a dietary supplement or health food.
4 . The composition of claim 3 , wherein the composition is in a dosage form selected from the group consisting of capsule, granule or tablet.
5 . The traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 1 , wherein the volatile oil is embedded by β-cyclodextrin to form an embedded volatile oil, the traditional Chinese medicine compound composition is prepared by compounding the embedded volatile oil and the extract, and the traditional Chinese medicine compound composition consists of:
1-100 parts by weight of Schizonepetae herba;
1-300 parts by weight of Astragali radix ; and
1-150 parts by weight of Atractylodes macrocephala.
6 . A preparation method of the traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 1 or 2 , comprising compounding a volatile oil obtained after heating and refluxing of Schizonepetae herba and an extract jointly extracted by Schizonepetae herba extract residue, Astragali radix and Atractylodes macrocephala ; wherein the preparation method specifically comprises:
(1) heating and refluxing of the Schizonepetae herba with purified water, then collecting the volatile oil of the Schizonepetae herba and embed it with β-cyclodextrin for standby;
(2) mixing the Schizonepetae herba extract residue filtered in step (1) with the Astragali radix and the Atractylodes macrocephala , adding purified water to continue extraction to obtain filtrates, and then combining the filtrates to obtain a traditional Chinese medicine extract; and
(3) mixing the volatile oil obtained in step (1) with the traditional Chinese medicine extract obtained in step (2) evenly to obtain a mixture, then taking a supernatant after concentrating and ethanol precipitating the mixture, and spray drying and sieving the supernatant to obtain the Chinese medicine compound composition with immune bidirectional regulation effect.
7 . The preparation method of the traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 6 , wherein in step (1), a volume ratio of the Schizonepetae herba to purified water is 1: (5-20), a number of heating and refluxing times of the Schizonepetae herba is 1-3 times, and an extraction time is 1-3 h.
8 . The preparation method of the traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 6 , wherein a volume ratio of purified water to a total volume of the Schizonepetae herba extract residue, the Astragali radix and the Atractylodes macrocephala is (6-8): 1, the Schizonepetae herba extract residue, the Astragali radix and the Atractylodes macrocephala are heated and refluxed twice, a first heating and refluxing time is 1-2 h, and a second heating and refluxing time is 0.5-1.5 h.
9 . The preparation method of the traditional Chinese medicine compound composition with immune bidirectional regulation effect of claim 6 , wherein in step (3), a concentration of the ethanol precipitating is 70%, a spray drying temperature is 150-250° C., and a sieving mesh is 60-80 mesh.