Compositions and methods for combinatorial drug discovery in nanoliter droplets

Inventors: Paul Blainey (Cambridge, MA); Anthony Kulesa (Cambridge, MA); Jared Kehe (Cambridge, MA)

Assignees: The Broad Institute, Inc.; Massachusetts Institute of Technology

A61K38/12 A61K31/14 A61K31/165 A61K31/4164 A61K31/4704 A61K31/506 A61K31/7048 A61P31/04

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Quick Facts

Patent No.: US 12673084
App. No.: 18/068,387
Granted: Jul 7, 2026
Kind: B2

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Abstract

Compounds and methods for combinatorial drug discovery in nanoliter droplets are described herein. More particularly, novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infections are described.

Claims (6)

1 . A composition comprising (i) a somatostatin receptor agonist and (ii) novobiocin.

2 . The composition of claim 1 , wherein the somatostatin receptor agonist is selected from the group consisting of Lanreotide, Pasireotide, and combination thereof.

3 . The composition of claim 1 , wherein the somatostatin receptor agonist is Pasireotide.

4 . A method of treating a subject having a bacterial infection, the method comprising administering to the subject an effective amount of the composition of claim 1 .

5 . A method of treating a subject having a bacterial infection, the method comprising administering to the subject an effective amount of the composition of claim 3 .

6 . A method of treating a subject having a bacterial infection, the method comprising administering to the subject (i) an effective amount of an antibiotic selected from the group consisting of novobiocin, erythromycin, and combination thereof; and (ii) an effective amount of Lanreotide.