IP Library › Granted Patent US 12673085
Granted Patent B2
US 12673085 · App. 17/425,374 · Granted Jul 7, 2026

CBM uses

Inventors: Graeme Rogers (St. Andrews, GB); Helen Connaris (St. Andrews, GB)
Assignee: OMIDEON LIMITED
A61K38/164A61P35/00
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Quick Facts
Patent No.
US 12673085
App. No.
17/425,374
Granted
Jul 7, 2026
Kind
B2
Abstract

The present disclosure provides molecules which modulate cell growth. These molecules include those that bind carbohydrates and may find application in the treatment and/or prevention of cell proliferation and/or differentiation disorders, cancer and/or it's migration and/or spread.

Claims (23)

1 . A method for the treatment of cancer, the method comprising administering a carbohydrate binding module to a subject in need thereof, wherein the carbohydrate binding module is a carbohydrate binding module of carbohydrate binding module Family 32 (CBM32).

2 . The method of claim 1 , wherein the carbohydrate binding module of carbohydrate binding module Family 32 (CBM32) comprises SEQ ID NO: 1 or SEQ ID NO: 2 or a carbohydrate binding portion thereof.

3 . The method of claim 1 , wherein the cancer is selected from the group consisting of:

(a) ovarian cancer;

(b) lung cancer;

(c) colon cancer; and

(d) breast cancer.

4 . The method according to claim 1 , wherein the carbohydrate binding module comprises a single CpCBM32, or two or more CBMs selected from the group consisting of:

(i) a CBM32; and

(ii) a CpCBM32.

5 . The method according to claim 1 , wherein the carbohydrate binding module comprises Cp2CBM32TD.

6 . The method of claim 1 , wherein the carbohydrate binding module is selected from the group consisting of:

(i) a molecule comprising two or more CBM32 (s);

(ii) a molecule comprising one, two or more CpCBM32 (s);

(iii) a molecule comprising one, two or more peptide(s) or protein(s) comprising a sequence of SEQ ID NO: 1, 2, or a carbohydrate binding portion thereof, and

(iv) a molecule comprising Cp2CBM32TD.

7 . The method of claim 6 , wherein the cancer is selected from the group consisting of:

(a) ovarian cancer;

(b) lung cancer;

(c) colon cancer; and

(d) breast cancer.

8 . A method of treating a refractory cancer, the method comprising administering to a subject in need thereof a carbohydrate binding module classified as a CBM32 or a molecule comprising a carbohydrate binding module classified as a CBM32.

9 . The method according to claim 8 , wherein the refractory cancer is refractory ovarian cancer.