Bladder, ureter, kidney, urethra, prostate and catheter anti-microbial, and biofilm prevention, reduction and treatment
A method for preventing and treating internal infections, e.g., urinary tract infections, caused by catheters is provided, in particular by reduction in catheter-associated biofilms. A coating composition is used to treat the catheter and applied through the catheter into the bladder or other body urinary tract organ to kill or neutralize microorganisms, including biofilms therein. The composition comprises a humectant and an antimicrobial with the antimicrobial including a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof. The coating layer has antimicrobial cidal or static activity for at least about one hour.
1 . A method for preventing or treating a urinary system infection, comprising the steps of:
instilling through a catheter an antimicrobial coating composition into a urinary system of a mammal;
the antimicrobial coating composition comprising:
about 0.07%≤H≤about 70%; and
about 0.0005%<A
wherein all percentages are by weight of the total composition;
wherein H is a humectant; and A is an antimicrobial agent;
the antimicrobial agent comprising a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
trapping, and neutralizing or killing harmful microorganisms in the urinary system or reducing or killing a biofilm in the urinary system;
wherein the antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the antimicrobial coating composition from the bladder or urinary tract.
2 . The method of claim 1 , further comprising coating an external surface of the catheter with the antimicrobial coating composition.
3 . The method of claim 1 , wherein the antimicrobial composition coats a surface of a bladder, ureter, urethra, prostate or kidney or any reconstructed organ of the urinary system.
4 . The method of claim 1 , wherein the antimicrobial coating composition coats a balloon portion of the catheter.
5 . The method of claim 1 , wherein the antimicrobial coating composition dwells in a bladder or urinary tract for 30 seconds to 5 minutes before removing the antimicrobial coating composition from the bladder or urinary tract.
6 . The method of claim 1 , wherein the composition meets the following compositional requirements:
about 0.0001%≤C<about 0.4%;
about 0.07%≤H≤about 65%; and
about 0.001%≤A≤about 5%;
wherein all percentages are by weight of the total composition;
wherein C is a carbohydrate gum.
7 . The method of claim 1 , wherein the microorganisms are selected from the group consisting of: Escherichia coli, Enterococcus spp., Klebsiella pneumoniae, Candida spp., coagulase-negative Staphylococci, S. aureus, Proteus mirabilis , and Pseudomonas aeruginosa, Pseudomonas fluorescens, Citrobacter spp., Acinetobacter spp., or combinations thereof.
8 . The method of claim 1 , wherein the antimicrobial coating composition effectively reduces or eliminates the biofilm in the urinary system.
9 . The method of claim 1 , wherein the antimicrobial coating composition is a solution comprising about 75% to about 98% by weight water and a pH of the composition is 6 to about 8.
10 . The method of claim 1 , wherein the antimicrobial coating composition leaves a coating layer having antimicrobial cidal or static activity for at least about one hour.
11 . The method of claim 1 , wherein the antimicrobial agent is cetylpyridinium chloride.
12 . A method for treating a urinary tract catheter or tubing system comprising:
moving a bolus of a first antimicrobial coating composition through tubing and equipment coupled to a catheter;
wherein an interior of the tubing is contacted with a flow or a static presence of the composition for 5 seconds to 60 minutes; wherein the first antimicrobial coating composition comprises:
about 0.07%≤H≤about 70%; and
about 0.0005%<A;
wherein all percentages are by weight of the total composition;
wherein H is a humectant; and A is an antimicrobial agent;
wherein the antimicrobial agent comprises a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
wherein the antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the antimicrobial coating composition from the bladder or urinary tract.
13 . The method of claim 12 , wherein the antimicrobial agent comprises cetyl pyridinium chloride.
14 . The method of claim 12 , further comprising:
coating an external surface of the catheter with the first or a second antimicrobial coating composition.
15 . The method of claim 14 , further coating an external surface of the catheter with the second antimicrobial coating composition, wherein the second antimicrobial composition is 10 to 500% more viscous than the first antimicrobial composition.
16 . The antimicrobial coating composition of claim 15 , wherein the first antimicrobial coating composition has a viscosity of less than 500 cps.
17 . A method for preventing, reducing or treating catheter-associated urinary tract infections in a urinary tract of a mammal, comprising:
applying a first coating of a first antimicrobial composition on an interior of a catheter, an exterior of the catheter, or both the interior and exterior of the catheter;
applying a second coating on a lining of a bladder of the mammal by instilling through the catheter a second antimicrobial composition into a bladder or kidney of a mammal;
in the first coating and the second coating, killing or neutralizing microorganisms encountered on a surface of the catheter or a surface of the bladder or kidney or encountered from an environment after the applying steps are performed; and
the composition comprising a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof;
wherein the first and second coating are different;
wherein the first or second antimicrobial coating composition dwells in a bladder or urinary tract for 5 sec to 1 hour before removing the first or second antimicrobial coating composition from the bladder or urinary tract;
wherein the first and second antimicrobial compositions are different and independently comprise:
about 0.07%≤H≤about 70%; and
about 0.001%≤A≤about 5%;
wherein all percentages are by weight of the total composition;
wherein H is a humectant; and A is an antimicrobial agent.
18 . The method of claim 17 , wherein the first antimicrobial coating composition is 10 to 500% more viscous than the second antimicrobial composition.
19 . The method of claim 17 , wherein the first coating, second coating or first and second coatings have an antimicrobial cidal or static activity for at least about one hour.
20 . The method of claim 17 , wherein the second antimicrobial composition is 10 to 500% more viscous than the first antimicrobial composition.