Cortical subarachnoid and intra ventricular brain interfaces
The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.
1 . A cortical subarachnoid and intraventricular brain interface device comprising:
an implantable pulse generator; and
a microelectrode catheter, wherein:
the microelectrode catheter comprises stimulating and recording electrodes; and
the stimulating and recording electrodes are configured for implantation into a spinal and intracranial subarachnoid space or for implantation into ventricles of a brain.
2 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the implantable pulse generator comprises a battery.
3 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the microelectrode catheter is configured to be implanted either on the brain convexity or into the ventricular system of an animal.
4 . The cortical subarachnoid and intraventricular brain interface device of claim 1 further comprising an external field transmitter for delivering data or energy to the implantable pulse generator.
5 . The cortical subarachnoid and intraventricular brain interface device of claim 4 wherein the external field transmitter is configured to provide an alternating magnetic field powered by a field driver at 20 kHz-1 MHz, which powers a magnetoelectric film at its mechanical resonant frequency.
6 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the implantable pulse generator is configured to generate stimulation amplitudes of at least 12.0 volts.
7 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the implantable pulse generator is configured to generate a pulse width of approximately 250 μs.
8 . The cortical subarachnoid and intraventricular brain interface device of claim 1 further comprising a wireless communication device.
9 . The cortical subarachnoid and intraventricular brain interface device of claim 8 wherein the wireless communication device comprises a coil.
10 . The cortical subarachnoid and intraventricular brain interface device of claim 8 wherein the wireless communication device is configured to:
transmit wireless signals to the implantable pulse generator; and
receive wireless signals from the implantable pulse generator.
11 . The cortical subarachnoid and intraventricular brain interface device of claim 8 wherein the wireless communication device is configured to communicate with the implantable pulse generator via a magnetoelectric backscatter protocol.
12 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the implantable pulse generator comprises a magnetoelectric film.
13 . The cortical subarachnoid and intraventricular brain interface device of claim 1 wherein the implantable pulse generator comprises a printed circuit board.
14 . A method of implanting a cortical subarachnoid and intraventricular brain interface device, the method comprising:
performing a lumbar puncture to access spinal subarachnoid space;
advancing a microelectrode catheter through the spinal subarachnoid space;
implanting one or more stimulating electrodes and recording electrodes into a spinal or intracranial subarachnoid space or into ventricles of a brain of a subject;
implanting an implantable pulse generator into the subject;
generating a stimulation signal via the implantable pulse generator; and
recording a response signal from the subject via the one or more recording electrodes.
15 . The method of claim 14 further comprising transmitting the response signal via a magnetoelectric backscatter protocol.
16 . The method of claim 14 wherein the implantable pulse generator comprises a magnetoelectric film.