Pyroelectric-based temperature sensing of transducer arrays for applying Tumor Treating Fields (TTFields)
TTFields are applied using transducer arrays made from a plurality of individual electrode elements. The temperatures of those electrode elements can be normalized by positioning respective regions of pyroelectric material in thermal contact with the electrode elements, and subsequently applying an AC signal to each of the electrode elements at respective duty cycles so that an alternating electric field is induced within the subject. For each of the regions of the pyroelectric material, an electrical characteristic that is related to temperature is measured after the AC signal turns off. The duty cycles of the AC signals that are applied to the electrode elements is adjusted until the measured electrical characteristics indicate that the temperatures of all the regions of the pyroelectric material have equalized to within 1° C.
1 . An apparatus for applying an electric field to a living subject, the apparatus comprising:
a plurality of first electrode elements, each of the first electrode elements having a front face and a rear face;
a plurality of first conductive leads, wherein each of the first conductive leads is disposed in electrical contact with a respective one of the first electrode elements;
a plurality of regions of a pyroelectric material, each of the regions of the pyroelectric material having a front face and a rear face, wherein the front face of each of the regions of the pyroelectric material is disposed in electrical and thermal contact with the rear face of the respective one of the first electrode elements;
a plurality of second electrode regions, each of which contacts the rear face of a respective one of the regions of the pyroelectric material;
at least one second conductive lead disposed in electrical contact with the plurality of second electrode regions; and
at least one temperature sensor positioned in thermal contact with at least one of the first electrode elements.
2 . The apparatus of claim 1 , wherein each of the second electrode regions is non-contiguous with all other second electrode regions, and wherein the at least one second conductive lead comprises a plurality of conductive leads, each of which is disposed in electrical contact with a respective one of the second electrode regions.
3 . The apparatus of claim 1 , wherein each of the second electrode regions is non-contiguous with all other second electrode regions, and wherein the at least one second conductive lead comprises a single lead disposed in electrical contact with all the second electrode regions.
4 . The apparatus of claim 1 , wherein all of the second electrode regions lie within a single sheet of conductive material, and wherein the at least one second conductive lead is disposed in electrical contact with the single sheet of conductive material.
5 . The apparatus of claim 1 , wherein each of the regions of the pyroelectric material is non-contiguous with all other regions of the pyroelectric material.
6 . The apparatus of claim 1 , wherein all of the regions of the pyroelectric material lie within a single sheet of pyroelectric material.
7 . The apparatus of claim 1 , wherein the at least one temperature sensor comprises at least one thermistor.
8 . The apparatus of claim 1 , further comprising:
a plurality of regions of a dielectric material with a dielectric constant of at least 20, wherein each of the regions of the dielectric material is disposed on the front face of a respective one of the first electrode elements, and
a self-adhesive support structure configured to hold the front face of each of the first electrode elements against a portion of the subject's body with the regions of the dielectric material disposed between the front face of the first electrode elements and the subject's body.
9 . The apparatus of claim 8 further comprising a layer of hydrogel disposed between the regions of the dielectric material and the subject's body.
10 . An apparatus for applying an electric field to a living subject, the apparatus comprising:
a plurality of first electrode elements, each of the first electrode elements having a front face and a rear face;
a plurality of first conductive leads, wherein each of the first conductive leads is disposed in electrical contact with a respective one of the first electrode elements;
an electrically insulating layer disposed on the rear face of each of the first electrode elements, wherein the electrically insulating layer is thermally conductive;
a sheet of pyroelectric material having a rear face and a front face, wherein the sheet of pyroelectric material is positioned behind the electrically insulating layer and disposed in thermal contact with the first electrode elements;
a plurality of second electrode regions positioned so that each of the second electrode regions makes electrical contact with a respective region of the rear face of the pyroelectric material;
a plurality of second conductive leads, each of which is disposed in electrical contact with a respective one of the second electrode regions;
a plurality of third electrode regions positioned so that each of the third electrode regions makes electrical contact with a respective region of the front face of the pyroelectric material, wherein the third electrode regions are sandwiched between the pyroelectric material and the electrically insulating layer; and
a plurality of third conductive leads, each of which is disposed in electrical contact with a respective one of the third electrode regions.
11 . The apparatus of claim 10 , wherein each of the second electrode regions has a longitudinal axis, wherein each of the third electrode regions has a longitudinal axis, and wherein the longitudinal axes of the second electrode regions are substantially perpendicular to the longitudinal axes of the third electrode regions.
12 . The apparatus of claim 10 , further comprising:
a plurality of regions of a dielectric material with a dielectric constant of at least 20, wherein each of the regions of the dielectric material is disposed on the front face of a respective one of the first electrode elements, and
a self-adhesive support structure configured to hold the front face of each of the first electrode elements against a portion of the subject's body with the regions of the dielectric material disposed between the front face of the first electrode elements and the subject's body.
13 . The apparatus of claim 12 further comprising a layer of hydrogel disposed between the regions of the dielectric material and the subject's body.
14 . The apparatus of claim 10 , further comprising at least one thermistor positioned in thermal contact with at least one of the first electrode elements.