Interferent detection in an analyte monitoring system

1 . An analyte monitoring system comprising:

an analyte sensor comprising:

an indicator structure;

analyte indicator molecules configured to reversibly bind an analyte in a first medium and, in response to being irradiated with analyte excitation light, emit analyte emission light indicative of whether the analyte is bound and therefore indicative of a level of the analyte in the first medium, wherein the analyte indicator molecules are distributed throughout the indicator structure;

interferent indicator molecules configured to reversibly bind an interferent in the first medium and, in response to being irradiated with interferent excitation light, emit interferent emission light indicative of whether the interferent is bound and therefore indicative of a level of the interferent in the first medium, wherein the interferent indicator molecules are distributed throughout the indicator structure, and the interferent indicator molecules are different than the analyte indicator molecules;

an analyte photodetector configured to output an analyte signal indicative of an amount of the analyte emission light received by the analyte photodetector,

an interferent photodetector configured to output an interferent signal indicative of an amount of the interferent emission light received by the interferent photodetector, and

a transceiver interface configured to convey an analyte measurement and an interferent measurement, wherein the analyte measurement is a measurement of the analyte signal, and the interferent measurement is a measurement of the interferent signal; and

a transceiver comprising: (i) a sensor interface configured to receive the analyte and interferent measurements conveyed by the transceiver interface of the analyte sensor and (ii) a processor configured to calculate an analyte level in a second medium using at least the analyte and interferent measurements.

2 . The analyte monitoring system of claim 1 , wherein calculating the analyte level in the second medium comprises:

calculating an analyte level in the first medium using at least the analyte measurement;

calculating an interferent level in the first medium using at least the interferent measurement; and

calculating the analyte level in the second medium using at least the calculated analyte level in the first medium and the calculated interferent level in the first medium.

3 . The analyte monitoring system of claim 2 , wherein calculating the analyte level in the second medium using at least the calculated analyte level in the first medium and the calculated interferent level in the first medium comprises:

adjusting one or more parameters of a conversion function based on at least the calculated interferent level in the first medium; and

using at least the adjusted conversion function and the calculated analyte level in the first medium to calculate the analyte level in the second medium.

4 . The analyte monitoring system of claim 1 , wherein the analyte sensor further comprises an analyte excitation light source configured to irradiate the analyte indicator molecules with the analyte excitation light.

5 . The analyte monitoring system of claim 4 , wherein the analyte excitation light source is further configured to irradiate the interferent indicator molecules with the interferent excitation light, and the analyte excitation light and the interferent excitation light are the same light.

6 . The analyte monitoring system of claim 4 , wherein the analyte sensor further comprises an interferent excitation light source configured to irradiate the interferent indicator molecules with the interferent excitation light, and a wavelength range of the analyte excitation light is different than a wavelength range of the interferent excitation light.

7 . The analyte monitoring system of claim 1 , wherein:

the interferent indicator molecules are first indicator molecules,

the interferent emission light is first interferent emission light,

the interferent is a first interferent,

the interferent photodetector is a first interferent photodetector,

the interferent signal is a first interferent signal,

the interferent measurement is a first interferent measurement, and

the analyte sensor further comprises:

second interferent indicator molecules configured to emit second interferent emission light indicative of a level of a second interferent in the first medium; and

a second interferent photodetector configured to output a second interferent signal indicative of an amount of the second interferent emission light received by the second interferent photodetector,

the transceiver interface is further configured to convey a second interferent measurement that is a measurement of the second interferent signal,

the sensor interface is further configured to receive the second interferent measurement conveyed by the transceiver interface of the analyte sensor, and

the processor is configured to calculate the analyte level in the second medium using at least the analyte measurement, the first interferent measurement, and the second interferent measurement.

8 . The analyte monitoring system of claim 7 , wherein the first medium is interstitial fluid, the second medium is blood, the analyte is glucose, the first interferent is insulin, and the second interferent is blood.

9 . The analyte monitoring system of claim 1 , wherein the first medium is interstitial fluid, the second medium is blood, the analyte is glucose, and the interferent is insulin or blood.

10 . The analyte monitoring system of claim 1 , wherein the indicator structure is a single, unitary structure.

11 . A method performed by an analyte monitoring system, the method comprising:

using analyte indicator molecules of an analyte sensor of the analyte monitoring system to reversibly bind an analyte in a first medium, wherein the analyte indicator molecules are distributed throughout an indicator structure of the analyte sensor;

using interferent indicator molecules of the analyte sensor to reversibly bind an interferent in the first medium, wherein the interferent indicator molecules are distributed throughout the indicator structure, and the interferent indicator molecules are different than the analyte indicator molecules;

using the analyte indicator molecules to emit analyte emission light indicative of whether the analyte is bound and therefore indicative of a level of the analyte in the first medium in response to being irradiated with analyte excitation light;

using the interferent indicator molecules to emit interferent emission light indicative of whether the interferent is bound and therefore indicative of a level of the interferent in the first medium in response to being irradiated with interferent excitation light;

using an analyte photodetector of the analyte sensor to output an analyte signal indicative of an amount of the analyte emission light received by the analyte photodetector;

using an interferent photodetector of the analyte sensor to output an interferent signal indicative of an amount of the interferent emission light received by the interferent photodetector;

using a transceiver interface of the analyte sensor to convey an analyte measurement and an interferent measurement, wherein the analyte measurement is a measurement of the analyte signal, and the interferent measurement is a measurement of the interferent signal;

using a sensor interface of a transceiver of the analyte monitoring system to receive the analyte and interferent measurements conveyed by the transceiver interface of the analyte sensor;

using a processor of the transceiver to calculate an analyte level in a second medium using at least the analyte and interferent measurements.

12 . The method of claim 11 , wherein calculating the analyte level in the second medium comprises:

calculating an analyte level in the first medium using at least the analyte measurement;

calculating an interferent level in the first medium using at least the interferent measurement; and

calculating the analyte level in the second medium using at least the calculated analyte level in the first medium and the calculated interferent level in the first medium.

13 . The method of claim 12 , wherein calculating the analyte level in the second medium using at least the calculated analyte level in the first medium and the calculated interferent level in the first medium comprises:

adjusting one or more parameters of a conversion function based on at least the calculated interferent level in the first medium; and

using at least the adjusted conversion function and the calculated analyte level in the first medium to calculate the analyte level in the second medium.

14 . The method of claim 11 , further comprising:

using an analyte excitation light source of the analyte sensor to irradiate the analyte indicator molecules of the analyte sensor with the analyte excitation light.

15 . The method of claim 14 , further comprising:

using the analyte excitation light source to irradiate the interferent indicator molecules of the analyte sensor with the interferent excitation light, and the analyte excitation light and the interferent excitation light are the same light.

16 . The method of claim 14 , further comprising:

using an interferent excitation light source of the analyte sensor to irradiate the interferent indicator molecules of the analyte sensor with the interferent excitation light, wherein a wavelength range of the analyte excitation light is different than a wavelength range of the interferent excitation light.

17 . The method of claim 11 , wherein:

the interferent indicator molecules are first indicator molecules,

the interferent emission light is first interferent emission light,

the interferent is a first interferent,

the interferent photodetector is a first interferent photodetector,

the interferent signal is a first interferent signal,

the interferent measurement is a first interferent measurement, and

the method further comprises:

using second interferent indicator molecules of the analyte sensor to emit second interferent emission light indicative of a level of a second interferent in the first medium; and

using a second interferent photodetector of the analyte sensor to output a second interferent signal indicative of an amount of the second interferent emission light received by the second interferent photodetector;

using the transceiver interface of the analyte sensor to convey a second interferent measurement that is a measurement of the second interferent signal; and

using the sensor interface of the transceiver to receive the second interferent measurement conveyed by the transceiver interface of the analyte sensor;

using the processor of the transceiver to calculate the analyte level in the second medium using at least the analyte measurement, the first interferent measurement, and the second interferent measurement.

18 . The method of claim 17 , wherein the first medium is interstitial fluid, the second medium is blood, the analyte is glucose, the first interferent is insulin, and the second interferent is blood.

19 . The method of claim 11 , wherein the first medium is interstitial fluid, the second medium is blood, the analyte is glucose, and the interferent is insulin or blood.

20 . The method of claim 11 , wherein the indicator structure is a single, unitary structure.