IP Library Granted Patent US 12678114
Granted Patent B2
US 12678114 · App. 18/198,541 · Granted Jul 14, 2026

Method for multi-energy X-ray imaging, X-ray facility, treatment system, computer program and electronically readable data carrier

Inventor: Stanislav Tashenov (Heroldsbach, DE)
Assignee: Siemens Healthineers AG
A61B6/482A61B6/032A61B6/4241
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Quick Facts
Patent No.
US 12678114
App. No.
18/198,541
Granted
Jul 14, 2026
Kind
B2
Abstract

A method is provided for multi-energy X-ray imaging of a field of view in order to display a contrast material, located in the field of view, having an atomic number of at least 65, (e.g., at least 73), and/or a k-edge of at least 60 keV. In the method, two image datasets having different X-ray spectra are recorded and are combined in order to ascertain display information of the contrast material, wherein the X-ray spectra are generated by using at least one spectrally acting filter, starting from a source spectrum of an X-ray source in such a way that the value of their differential spectrum has a maximum, which includes a range, beginning at the k-edge of the contrast material, of higher absorption by the contrast material.

Claims (55)

1 . A method for multi-energy X-ray imaging of a field of view in order to display a contrast material, located in the field of view, the method comprising:

introducing an embolization agent into a target area of a patient, wherein the embolization agent comprises the contrast material and a chemical active ingredient and/or radioactive active ingredient, and wherein the embolization agent accumulates on a lesion in the target area of the patient to treat the lesion;

recording two image datasets having different X-ray spectra subsequent to the introducing of the embolization agent;

combining the two image datasets;

ascertaining display information of the contrast material using the combined two image datasets; and

displaying the display information of the contrast material in the field of view,

wherein the contrast material has an atomic number of at least 65 and/or a k-edge of at least 60 keV, and

wherein the X-ray spectra are generated by using at least one spectrally acting filter, starting from a source spectrum of an X-ray source in such a way that a value of differential spectrum has a maximum, which comprises a range, beginning at the k-edge of the contrast material, of higher absorption by the contrast material.

2 . The method of claim 1 , wherein the atomic number of the contrast material is at least 73.

3 . The method of claim 1 , wherein a breadth of the maximum is 5 to 40 keV, a portion of the maximum of the differential spectrum is at least 90%, a same source spectrum of the X-ray source is taken as a starting point for the different X-ray spectra, or a combination thereof.

4 . The method of claim 3 , wherein the portion of the maximum of the differential spectrum is at least 95%.

5 . The method of claim 3 , wherein, when using the same source spectrum, the contrast material is used as a first filter material of a first filter of at least one filter.

6 . The method of claim 5 , wherein a second X-ray spectrum of the different X-ray spectra is spectrally unfiltered or a filter material having a higher atomic number than the contrast material is used as a second filter material of a second filter of the at least one filter.

7 . The method of claim 6 , wherein the second filter material is selected such that an interval of the k-edge of the second filter material from that of the contrast material is 5 to 30 keV.

8 . The method of claim 6 , wherein, when the contrast material is tantalum, platinum, or gold, bismuth is used as the second filter material, or

when the contrast material is holmium or ytterbium, tantalum is used as the second filter material.

9 . The method of claim 1 , wherein the display information is ascertained by subtraction of the image datasets, and/or

wherein the display information is ascertained as a display image showing a distribution of the contrast material.

10 . The method of claim 1 , further comprising:

introducing an additional amount of the embolization agent into the target area of the patient as a function of the display information of the contrast material.

11 . The method of claim 10 , wherein the function of the display information comprises a density of the contrast material.

12 . A method for imaging after an embolization procedure using an embolization agent comprising a contrast material, in a field of view of a patient, the method comprising:

introducing the embolization agent into a target area of the patient, wherein the embolization agent comprises the contrast material and a chemical active ingredient and/or radioactive active ingredient, and wherein the embolization agent accumulates on a lesion in the target area of the patient to treat the lesion;

recording two image datasets having different X-ray spectra subsequent to the introducing of the embolization agent;

combining the two image datasets;

ascertaining display information of the contrast material using the combined two image datasets; and

imaging after the embolization procedure using the embolization agent comprising the contrast material,

wherein the contrast material has an atomic number of at least 65 and/or a k-edge of at least 60 keV.

13 . The method of claim 12 , wherein the embolization agent comprises microparticles.

14 . The method of claim 12 , wherein the atomic number of the contrast material is at least 73.

15 . A method for imaging a contrast agent in a field of view, wherein the contrast agent has a contrast material, the method comprising:

introducing an embolization agent into a target area of a patient, wherein the embolization agent comprises the contrast material and a chemical active ingredient and/or radioactive active ingredient, and wherein the embolization agent accumulates on a lesion in the target area of the patient to treat the lesion;

recording two image datasets having different X-ray spectra subsequent to the introducing of the embolization agent;

combining the two image datasets;

ascertaining display information of the contrast material using the combined two image datasets; and

imaging the contrast agent in the field of view,

wherein the contrast material has an atomic number of at least 65 and/or a k-edge of at least 60 keV.

16 . The method of claim 15 , wherein the atomic number of the contrast material is at least 73.

17 . A system comprising:

an X-ray facility having:

a control facility; and

a filtering facility comprising at least one filter,

wherein the control facility is configured to:

introduce an embolization agent into a target area of a patient, wherein the embolization agent comprises a contrast material and a chemical active ingredient and/or radioactive active ingredient, and wherein the embolization agent is configured to accumulate on a lesion in the target area of the patient to treat the lesion;

record two image datasets having different X-ray spectra subsequent to the introduction of the embolization agent;

combine the two image datasets;

ascertain display information of the contrast material using the combined two image datasets; and

display the display information of the contrast material in a field of view,

wherein the contrast material has an atomic number of at least 65 and/or a k-edge of at least 60 keV, and

wherein the X-ray spectra are generated by using the at least one filter of the filtering facility, starting from a source spectrum of an X-ray source in such a way that a value of differential spectrum has a maximum, which comprises a range, beginning at the k-edge of the contrast material, of higher absorption by the contrast material.

18 . The system of claim 17 , wherein the embolization agent comprises microparticles.

19 . The system of claim 17 , wherein the embolization agent comprises a chemical active ingredient, a radioactive active ingredient, a plastic carrier material, or a combination thereof, and

wherein the chemical active ingredient and/or the radioactive active ingredient is configured for transarterial chemoembolization and/or for selective internal radiation therapy.

20 . The system of claim 17 , wherein a portion of the contrast material in the embolization agent is selected for minimization of a buoyancy in blood, a carrier fluid, or a combination thereof.

21 . The system of claim 20 , wherein the carrier fluid comprises a saline solution, a contrast agent, or a combination thereof.