Multi-axis tumor margin marker system
View Patent ↗A multi-axis tumor excision marker system is configured to deposit markers along multiple axes radially about a tumor to define a boundary of margin tissue for excision. A catheter may deploy a marker extension that extends to a margin tissue boundary for depositing the marker. The marker extension may be a shape memory material that extends radially outward from catheter opening or may be directed radially outward by a guide head. The radiopaque marker may be a phase change marker, such as an adhesive that changes from a liquid to a solid. A marker may be a discrete marker and may have an extension portion that extends from an anchor portion. An envelopment marker has a plurality of marker extensions that each extend along an offset axis from each other. A spiral maker includes a maker extension that spirals around the margin boundary tissue.
1 . A multi-axis tumor marker system comprising:
a) a catheter having a proximal and a distal end with a distal end opening; and
b) a marker extension configured to retain a marker and extend from the distal end opening of the catheter for depositing said marker;
wherein the marker extension is configured to deposit said marker by releasing said marker from the marker extension;
wherein the marker is deposited along multiple axes radially about a tumor to define a boundary of margin tissue for excision;
wherein the marker extension comprises an axial marker-extension configured to extend axially from the distal end opening of the catheter to deposit said marker along a catheter axis;
wherein the axial marker-extension is configured to deposit said marker on a distal end of said boundary of said margin tissue to produce a distal marker; and
wherein the marker extension comprises a plurality of radial marker-extensions each configured to extend radially from the distal end of the catheter and configured to deposit said marker along a radial axis and on a radial boundary of said margin tissue to produce a radial marker.
2 . The multi-axis tumor marker system of claim 1 , wherein the plurality of radial marker-extensions comprises three radial marker-extensions that extend radially outward an offset degree of 45 degrees or more.
3 . The multi-axis tumor marker system of claim 1 , wherein the plurality of radial marker-extensions comprises three radial marker-extensions that extend radially outward an offset degree of 60 degrees or more.
4 . The multi-axis tumor marker system of claim 1 , further comprising a guide head configured to guide the marker-extensions radially outward, said guide head comprising a radial guide along a radial guide aperture.
5 . The multi-axis tumor marker system of claim 1 , wherein the marker is a phase change marker and wherein the phase change marker is a liquid in the marker extension and wherein the phase change marker changes to a solid upon deposition in said margin tissue.
6 . The multi-axis tumor marker system of claim 1 , wherein the phase change marker comprises a radiopaque material.
7 . The multi-axis tumor marker system of claim 1 , wherein the phase change marker comprises an adhesive.
8 . The multi-axis tumor marker system of claim 7 , wherein the phase change marker comprises a radiopaque material.
9 . The multi-axis tumor marker system of claim 7 , wherein the phase change marker comprises a cyanoacrylate adhesive.
10 . The multi-axis tumor marker system of claim 9 , wherein the phase change marker comprises a radiopaque material.
11 . The multi-axis tumor marker system of claim 1 , wherein the axial marker-extension is configured to deposit said marker on a proximal end of said boundary of said margin tissue to produce a proximal marker.
12 . The multi-axis tumor marker system of claim 1 , wherein the marker-extension comprises shape memory metal that is configured to extend radially outward from the distal end opening of the catheter.
13 . The multi-axis tumor marker system of claim 1 , wherein the marker comprises a shape memory wire marker.
14 . The multi-axis tumor marker system of claim 13 , wherein the shape memory wire markers comprise an anchor portion.
15 . The multi-axis tumor marker system of claim 14 , wherein the anchor portion comprises radiopaque material.
16 . The multi-axis tumor marker system of claim 15 , wherein the anchor portion has a convoluted shape upon advancement from the marker extension.
17 . The multi-axis tumor marker system of claim 16 , wherein the anchor portion is configured to rotate upon deployment to prevent migration of the marker in tissue.
18 . The multi-axis tumor marker system of claim 13 , wherein the shape memory wire marker is an envelopment marker that extends from the distal end of the catheter and is configured to extend along a curved boundary of the margin tissue.
19 . The multi-axis tumor marker system of claim 13 , wherein the shape memory wire marker is a spiral envelopment marker that extends from the distal end of the catheter and is configured to spiral around a boundary of the margin tissue.
20 . The multi-axis tumor marker system of claim 1 , wherein the radial marker comprises a shape memory wire marker.
21 . The multi-axis tumor marker system of claim 1 , wherein the radial marker comprises a seed marker that is a discrete physical marker comprising a radiopaque material.