IP Library Granted Patent US 12678336
Granted Patent B2
US 12678336 · App. 18/770,691 · Granted Jul 14, 2026

Hydration-responsive shape-memory keratin composite fibers and fabrication methods thereof

Inventors: Jinlian Hu (Hong Kong, HK); Xiaoyun Xu (Hong Kong, HK)
Assignee: City University of Hong Kong
A61F13/01012A61F13/01038A61F13/01042A61L15/28A61L15/32A61L15/42D01D5/06D01F1/10D01F4/00D01F11/02F03G7/0614A61L2400/04A61L2400/12A61L2400/16D10B2211/01D10B2401/02D10B2505/00D10B2509/022
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Quick Facts
Patent No.
US 12678336
App. No.
18/770,691
Granted
Jul 14, 2026
Kind
B2
Abstract

Hydration-responsive shape-memory keratin composite fibers are provided. These fibers have a keratin network structure formed by keratin α-helices bonded by disulfide bonds. Incorporated within the structure are cellulose nanocrystals (CNCs), which provide hydrogen bonds and stabilize the α-helix structure, introducing a hydration-responsive switch. Specifically, the CNCs are configured to arrange and connect the keratin α-helices, aligning their coil axis along the fiber axis.

Claims (11)

1 . A method of fabricating a hydration-responsive shape-memory keratin composite fiber, comprising:

conducting a reduction reaction on a keratin source for extracting keratin molecules utilizing L-cysteine and urea;

mixing the extracted keratin molecules, cellulose nanocrystals (CNCs) and a reducing agent in an alkaline solution to obtain a homogenous keratin spinning dope;

extruding the keratin spinning dope through a needle by a pump to a coagulation bath to form as-spun fibers;

oxidizing the as-spun fibers to generate disulfide bonds between α-helix subunits to form keratin α-helices; and

crosslinking the keratin α-helices to form hydration-responsive shape-memory keratin composite fibers.

2 . The method of claim 1 , wherein the extruding is performed with an extrusion speed of 0.8-1 mL/h.

3 . The method of claim 1 , wherein the keratin source comprises wool, feathers, horns, hooves, mammalian hair, mammalian skin, mammalian nails and mammalian claws.

4 . The method of claim 1 , wherein the coagulation bath is a sodium dihydrogen phosphate aqueous solution.

5 . The method of claim 4 , wherein the coagulation bath has a pH less than 4.3 to facilitate keratin solidification and ion diffusion.

6 . The method of claim 1 , wherein the crosslinking is utilizing glutaraldehyde as a crosslinker.