Remineralizing dental material
A subject of the invention is a remineralizing dental material, having at least one cation and at least one anion, which are configured as partner ions for forming a remineralization substance. In accordance with the invention at least one of the partner ions is multivalent and is included as counterion in a coacervate. A further subject of the invention is a kit for producing such a dental material, and also the use thereof.
1 . A kit for producing a remineralizing dental material, wherein the remineralizing dental material has at least one cation and at least one anion, which are configured as partner ions for forming a remineralization substance, wherein at least one of the partner ions is multivalent and is included as counterion with a polyelectrolyte in a coacervate, the kit comprising the following constituents:
a. a first component which comprises at least one coacervate with one of the partner ions as counterion of the coacervate;
b. a second component comprising water;
wherein the second of the partner ions is included either as free ion in aqueous solution in component b and/or as counterion of a second coacervate in one of the two components.
2 . The kit as claimed in claim 1 , wherein at least one of the components has a pH of 7 to 10 at 23° C.
3 . The kit as claimed in claim 1 , wherein components a and b are stored in an apparatus suitable for mixing.
4 . The kit as claimed in claim 1 , wherein component a comprises at least one first coacervate powder comprising calcium ions as counterions, and at least one second coacervate powder comprising multivalent anions as partner ions.
5 . The kit as claimed in claim 1 , wherein at least one of the components is a solid.
6 . The kit as claimed in claim 5 , wherein at least one of the components is a powder.
7 . The kit as claimed in claim 1 , wherein at least one of the components is a liquid.
8 . The kit as claimed in claim 7 , wherein the liquid has a dynamic viscosity of greater than 100 mPas.
9 . The kit as claimed in claim 1 , wherein the two components are pastes.
10 . The kit as claimed in claim 1 , wherein the two components are gels.
11 . The kit as claimed in claim 1 , which comprises a further component c, which comprises an adhesion promoter.
12 . The kit as claimed in claim 11 , wherein the polyelectrolyte is an organic polyelectrolyte selected from the group consisting of:
a. polymers and copolymers which contain carboxylic acid groups, phosphoric acid groups, phosphonic acid groups and/or sulfonic acid groups, and also their salts and their partial esters;
b. acidic proteins, acidic protein derivatives, and their salts; and
c. acidic polysaccharides selected from carrageenan, pectin, algic acid, and hyaluronic acid, and their salts.
13 . The kit as claimed in claim 12 , wherein the organic polyelectrolyte is selected from the group consisting of polycarboxylic acids, polyalkylene phosphoric acids, polyalkylene phosphonic acids, and polysulfonic acids, and also their salts and their partial esters.
14 . The kit as claimed in claim 13 , wherein the organic polelectrolyte is selected from the group consisting of poly(meth)acrylic acid, polyaspartic acid, polyitaconic acid, and polyglutamic acid, and also their salts.
15 . The kit as claimed in claim 12 , wherein the organic polyelectrolyte is selected from lysozyme and gelatin.
16 . The kit as claimed in claim 12 , wherein the organic polyelectrolyte is selected from carrageenan, pectin, alginic acid, and hyaluronic acid, and their salts.
17 . The kit as claimed in claim 1 , wherein one of the partner ions is multivalent and is included as counterion in a coacervate, and a second partner ion is included in aqueous solution, with at least one of the components further comprising a second polyelectrolyte, which has a different charge from the polyelectrolyte of the coacervate.
18 . The kit as claimed in claim 1 , wherein the polyelectrolyte is an anionic polyelectrolyte for forming the coacervates with multivalent cations, and the anionic polyelectrolyte is selected from the group consisting of organic polyelectrolytes.
19 . The kit as claimed in claim 18 , wherein the multivalent cations are selected from the group consisting of mineral-forming cations.
20 . The kit as claimed in claim 19 , wherein the multivalent cations are selected from the group consisting of Ba 2+ , Ca 2+ , Sr 2+ , Tb 3+ , and Yb 3+ .
21 . The kit as claimed in claim 20 , wherein the multivalent cations are Ca 2+ and/or mixtures of metal cations with Ca 2+ .
22 . The kit as claimed in claim 1 , wherein the polyelectrolyte is a cationic polyelectrolyte for forming the coacervates with multivalent anions, and the cationic polyelectrolyte is selected from organic polyelectrolytes.
23 . The kit as claimed in claim 22 , wherein the organic polyelectrolyte is selected from the group consisting of polyallylamine, linear or branched polyethyleneimine, chitosan, polylysine, and polyarginine and also their salts.
24 . The kit as claimed in claim 23 , wherein the organic polyelectrolyte is polyallylamine hydrochloride (PAH).
25 . The kit as claimed in claim 22 , wherein the multivalent anions are selected from the group consisting of mineral-forming anions.
26 . The kit as claimed in claim 25 , wherein the multivalent anions are selected from the group consisting of orthophosphate ions, diphosphate ions, metaphosphate ions, silicate ions, sulfate ions, tungstate ions, vanadate ions, molybdate ions, and carbonate ions.
27 . The kit as claimed in claim 26 , wherein the multivalent anions are orthophosphate ions and/or mixtures of orthophosphate ions with mineral-forming anions.
28 . A method for using a kit as claimed in claim 1 , with the steps of:
i. applying constituent b to dentin and/or enamel,
ii. applying constituent a to the dentin with constituent b and/or to the enamel with constituent b.
29 . A method for using a kit as claimed in claim 1 , with the steps of:
i. mixing constituent a and constituent b,
ii. applying the mixture to dentin and/or enamel.
30 . The method as claimed in claim 28 , comprising applying constituent b to dentin and/or enamel as a liquid.