Sanitizing compositions containing ionic liquid
Disclosed herein are sanitizing compositions comprising an alcohol and non-volatile component. In certain embodiments, sanitizing compositions comprise an ionic liquid comprising a choline cation and fatty acid anion for use in sanitizing surfaces. In some embodiments, the ionic liquid is further formulated for topical administration.
1 . A method of sanitizing a skin surface, comprising applying to the skin surface a composition comprising an ionic liquid having a cationic component and an anionic component, wherein:
the anionic component is bistriflimide anion, a geranate anion, dodecyldimethyl ammonia propane sulfonate anion, or a geraniolate anion,
the cationic component is benzyl pyridinium cation, benzyl dimethyl dodecycl ammonium cation, a choline cation, benzethonium cation, or a phosphonium cation, and
the composition is non-irritating to skin.
2 . The method of claim 1 , wherein the ionic liquid is a deep eutectic solvent having a melting point lower than the melting points of the cationic component and anionic component individually.
3 . The method of claim 1 , wherein the ionic liquid inhibits or decreases microbial growth on the skin surface.
4 . The method claim 3 , wherein the microbial growth is growth of a virus, bacterium, fungus, mold, protozoan, parasite, or combinations thereof.
5 . The method of claim 4 , wherein the bacterium is a gram-negative bacterium.
6 . The method of claim 5 , wherein the gram-negative bacterium is an Escherichia, Salmonella, Klebsiella bacterium, or any combination thereof.
7 . The method of claim 6 , wherein the Escherichia bacterium is E. coli.
8 . The method of claim 4 , wherein the bacterium is a gram-positive bacterium.
9 . The method of claim 8 , wherein the gram-positive bacterium is a Staphylococcus or Streptococcus bacterium.
10 . The method of claim 9 , wherein the Staphylococcus bacterium is methicillin-resistant S. aureus (MRSA).
11 . The method of claim 4 , wherein the virus is an Ebolavirus, Coronavirus, Rotavirus, Alphainfluenzavirus, Betainfluenzavirus, Deltainfluenzavirus, Gammainfluenzavirus, or any combination thereof.
12 . The method of claim 4 , wherein the virus is a Coronavirus.
13 . The method of claim 12 , wherein the Coronavirus is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
14 . The method of claim 1 , wherein the anionic component is a geranate.
15 . The method of claim 1 , wherein the cationic component is a choline cation.
16 . The method of claim 1 , wherein the cationic component is a choline cation, and wherein the anionic component is a geranate anion.
17 . The method of claim 16 , wherein the cationic component and the anionic component are in a molar ratio ranging from 1:1 to 1:2 (cationic component to anionic component).
18 . The method of any one of claim 16 , wherein the composition comprises from about 1% to about 8.5% of choline geranate by weight.
19 . The method of claim 18 , wherein the composition further comprises an alcohol in an amount of from about 50% to about 95% by weight.
20 . The method of claim 19 , wherein the alcohol is ethanol, isopropyl alcohol, n-propyl alcohol, or combinations thereof.
21 . The method of any one of claim 19 , wherein the composition further comprises from about from about 0.05% to about 5% by weight of hydroxypropyl cellulose.
22 . The method of claim 21 , wherein the composition further comprises from about 0.5% to about 5% by weight of glycerin.
23 . The method of claim 1 , wherein the composition is in the form of a liquid, a gel, a foam, a lotion, or a soap.
24 . The method of claim 1 , wherein the skin surface is a hand skin surface.
25 . The method of claim 1 , wherein the ionic liquid remains on the skin surface for at least two hours.
26 . The method of claim 1 , wherein the ionic liquid remains on the skin surface for at least four hours.
27 . The method of claim 1 , wherein the ionic liquid remains on the skin surface until cleaned or washed off.