IP Library › Granted Patent US 12678400
Granted Patent B2
US 12678400 · App. 18/076,023 · Granted Jul 14, 2026

Implantable devices for drug delivery with reduced burst release

Inventors: Rajesh A. Patel (South San Francisco, CA); Sunil Sreedharan (South San Francisco, CA); Sunil R. Bhonsle (South San Francisco, CA)
Assignee: ReacX Pharmaceuticals, Inc.
A61K9/0024A61K9/4808A61K9/4816A61K9/4833A61K31/197A61K31/4045A61K31/4458A61K31/485A61K31/506A61K38/26B29C48/06B29C48/21B29K2001/08B29K2023/083B29K2105/0035B29K2995/006B29L2031/753
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Quick Facts
Patent No.
US 12678400
App. No.
18/076,023
Granted
Jul 14, 2026
Kind
B2
Abstract

The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Claims (25)

1 . A method of delivering a pharmaceutical substance or drug to a patient in need thereof, the method comprising:

implanting a device into the patient, wherein the pharmaceutical substance or drug is released from the device into the patient, and wherein the device, after implantation, comprises:

a core comprising: (i) a polymeric material comprising poly(vinyl alcohol); and (ii) the pharmaceutical substance or drug; and

a porous outer shell comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug,

wherein the porous outer shell has a thickness of about 1 micrometer to about 5 micrometers, and

wherein the device is rod-shaped and has a length of about 0.5 cm to 10 cm and a diameter of about 1 mm to about 8 mm, and wherein, after implantation, the pharmaceutical substance or drug diffuses through the porous outer shell.

2 . The method of claim 1 , wherein a period of sustained release of the pharmaceutical substance into the body of the patient is from about 1 month to about 1 year.

3 . The method of claim 1 , wherein a period of sustained release is from 6 months to 1 year.

4 . The method of claim 1 , wherein a period of sustained release is from 6 months to 9 months.

5 . The method of claim 1 , wherein a period of sustained release is about 9 months.

6 . A method of treating a disease in a subject, the method comprising implanting a device into the subject, wherein the device, after implantation, comprises:

a core comprising: (i) a polymeric material comprising poly(vinyl alcohol); and (ii) a pharmaceutical substance or drug; and

a porous outer shell comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug,

wherein the porous outer shell has a thickness of about 1 micrometer to about 5 micrometers, and

wherein the implantable device is rod-shaped and has a length of about 0.5 cm to 10 cm and a diameter of about 1 mm to about 8 mm, and wherein, after implantation, the pharmaceutical substance or drug diffuses through the porous outer shell.

7 . The method of claim 6 , wherein the diameter of the implantable device is about 1 mm to about 7 mm.

8 . A method of forming an implantable device, the method comprising:

extruding a first composition to form a core, the first composition comprising: (i) a polymeric material comprising poly(vinyl alcohol); and (ii) a pharmaceutical substance or drug; and

coating the core with a second composition to form an outer shell that is free of the pharmaceutical substance or drug, the second composition comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the outer shell has a thickness of about 1 micrometer to about 5 micrometers, wherein the implantable device has diameter of about 1 mm to about 8 mm, and wherein, after implantation, the pharmaceutical substance or drug diffuses through pores of the outer shell.

9 . The method of claim 8 , wherein the implantable device is rod-shaped and having a length of about 0.5 cm to 10 cm in length.

10 . The method of claim 8 , wherein the implantable device is rod-shaped and having a diameter of about 1 mm to about 7 mm.

11 . A method of forming an implantable device, the method comprising:

co-extruding a first composition and a second composition, wherein the first composition is extruded to form a core, the first composition comprising (i) a first polymeric material comprising poly(vinyl alcohol); and (ii) a pharmaceutical substance or drug; and the co-extruded second composition forming an outer shell around the core that is free of the pharmaceutical substance or drug, the second composition comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the outer shell has a thickness of about 1 micrometer to about 5 micrometers, wherein the implantable device has diameter of about 1 mm to about 8 mm, and wherein, after implantation, the pharmaceutical substance or drug diffuses through pores of the outer shell.

12 . The method of claim 11 , wherein the implantable device is rod-shaped and having a length of about 0.5 cm to 10 cm in length.

13 . The method of claim 11 , wherein the implantable device is rod-shaped and having a diameter of about 1 mm to about 7 mm.