Compositions containing pterosin compound and derivatives thereof active ingredients for prevention or treatment of degenerative brain diseases
The present invention relates to compositions containing a pterosin compound and derivatives thereof as active ingredients for the prevention or treatment of degenerative brain diseases and, more specifically, to a pharmaceutical composition for the prevention or treatment of degenerative brain diseases and a food composition for the prevention or alleviation of degenerative brain diseases, each of which contains a pterosin compound defined by chemical formula 1 or a derivative thereof as an active ingredient. A method of the present invention can be favorably used to provide a therapeutic agent for preventing or treating degenerative brain diseases, a food for alleviating degenerative brain diseases, or a functional food for the promotion of cognitive functions, by using a pterosin compound extracted from Pteridium aquilinum and derivatives thereof.
1 . A method for treating or alleviating Alzheimer's disease in a human, the method consisting essentially of administering to the human in need thereof a therapeutically effective amount of a purified composition from a bracken fern consisting of a compound defined by Chemical Formula 1 or a salt thereof as an effective ingredient:
wherein,
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 8 are each independently H, OH, an alkyl or alcohol of 1 to 4 carbon atoms, or alkyl-O-glucose; and
R 7 is one selected from the group consisting of halogen, H, OH, O-alkyl, O-alkenyl, O-alkynyl, O-alcohol, O-carboxyl, O-ether, O-sulfonic acid (—SO 3 H), O-cycloalkyl, O-heterocycloalkyl, glucose, and O-glucose,
wherein the compound is selected from the group consisting of (2R)-Pterosin B, (2R,3R)-Pterosin C, (2S,3R)-Pterosin C, (2R)-Pteroside B, (2S,3R)-Pteroside C, (2R,3R)-Pteroside C, (3R)-Pterosin D and (3S)-Pteroside D.