IP Library Granted Patent US 12678421
Granted Patent B2
US 12678421 · App. 18/024,666 · Granted Jul 14, 2026

Composition for enhancing NAMPT gene expression

Inventors: Hiroaki Yamamoto (Tokyo, JP); Kenichi Ooe (Tokyo, JP); Yoshinori Katakura (Fukuoka, JP)
Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION; DAICEL CORPORATION
A61K31/353
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Quick Facts
Patent No.
US 12678421
App. No.
18/024,666
Granted
Jul 14, 2026
Kind
B2
Abstract

An object of the present disclosure is at least to provide a technique for enhancing expression of a NAMPT gene. The object is achieved by a composition for enhancing NAMPT gene expression, the composition containing an equol compound as an active ingredient.

Claims (18)

1 . A method for enhancing NAMPT gene expression in a subject in need thereof, the method comprising administering an effective amount of an equol compound to the subject, wherein the equol compound is represented by formula (1) or a mixture of equol compounds represented by formula (1):

where R 1 to R 7 each represent a hydroxyl group or a hydrogen atom.

2 . The method according to claim 1 , wherein the equol compound is comprised in a composition.

3 . The method according to claim 2 , wherein the composition is a food or beverage product.

4 . The method according to claim 2 , wherein the composition is a pharmaceutical product.

5 . A method for preventing or ameliorating sarcopenia, heart disease, chronic obstructive pulmonary disease, or a viral infection in a subject in need thereof, the method comprising administering an effective amount of an equol compound to the subject, wherein the equol compound is represented by formula (1) or a mixture of equol compounds represented by formula (1):

where R 1 to R 7 each represent a hydroxyl group or a hydrogen atom.

6 . The method according to claim 5 , wherein the equol compound is comprised in a composition.

7 . The method according to claim 6 , wherein the composition is a food or beverage product.

8 . The method according to claim 6 , wherein the composition is a pharmaceutical product.

9 . A method for anti-aging in a subject in need thereof, the method comprising administering an effective amount of an equol compound to the subject, wherein the equol compound is represented by formula (1) or a mixture of equol compounds represented by formula (1):

where R 1 to R 7 each represent a hydroxyl group or a hydrogen atom.

10 . The method according to claim 9 , wherein the equol compound is comprised in a composition.

11 . The method according to claim 10 , wherein the composition is a food or beverage product.

12 . The method according to claim 10 , wherein the composition is a pharmaceutical product.

13 . The method according to claim 1 , wherein the equol compound comprises at least an equol compound represented by formula (2)

14 . The method according to claim 5 , wherein the equol compound comprises at least an equol compound represented by formula (2)

15 . The method according to claim 9 , wherein the equol compound comprises at least an equol compound represented by formula (2)