Sulcardine salts
Sulcardine salts other than sulfuric acid salts of sulcardine, including crystalline sulcardine salts, are provided herein. Pharmaceutical compositions comprising such salts and methods of treating arrhythmias comprising administering effective amounts of such salts are also provided.
1 . A solid form, comprising a crystalline hydrochloric acid salt of sulcardine characterized by an XRPD pattern comprising peaks at approximately 12.3, 13.0, and 17.8° 2θ.
2 . The solid form of claim 1 , wherein the XRPD pattern further comprises peaks at approximately 13.9, 17.4, and 23.9° 2θ.
3 . The solid form of claim 2 , wherein the XRPD pattern further comprises peaks at approximately 20.3 and 21.9° 2θ.
4 . The solid form of claim 1 , characterized by an XRPD pattern that matches the XRPD pattern presented in FIG. 17 .
5 . A solid form, comprising a crystalline hydrochloric acid salt of sulcardine characterized by an XRPD pattern comprising peaks at approximately 13.5, 19.6, and 20.6° 2θ.
6 . The solid form of claim 5 , wherein the XRPD pattern further comprises peaks at approximately 10.1, 11.8, and 16.4° 2θ.
7 . The solid form of claim 6 , wherein the XRPD pattern further comprises peaks at approximately 17.8, 19.4, and 25.5° 2θ.
8 . The solid form of claim 5 , characterized by an XRPD pattern that matches the XRPD pattern presented in FIG. 17 A .
9 . A pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and a solid form, comprising a crystalline hydrochloric acid salt of sulcardine characterized by an XRPD pattern comprising peaks at approximately 12.3, 13.0, and 17.8° 2θ.
10 . The pharmaceutical composition of claim 9 , further comprising a capsule.
11 . A pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and solid form, comprising a crystalline hydrochloric acid salt of sulcardine characterized by an XRPD pattern comprising peaks at approximately 13.5, 19.6, and 20.6° 2θ.
12 . The pharmaceutical composition of claim 11 , further comprising a capsule.