Method for preventing and/or treating systemic inflammation
View Patent ↗The present invention is directed to a method for preventing and/or treating aging-related cognitive impairment in the central nervous system. The method comprises administering to a subject in need thereof a Ppangela activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.
1 . A method for treating a patient who has systemic inflammation, comprising the step of:
administering to the patient an effective amount of 2-[4-(1,1-dimethylethyl) phenyl]-1H-benzimidazole, or a pharmaceutically acceptable salt thereof.
2 . The method according to claim 1 , wherein the patient is over the age of 40.
3 . The method according to claim 1 , wherein said compound is administered by systemic administration.
4 . The method according to claim 3 , wherein said compound is administered by oral administration.
5 . The method according to claim 4 , wherein the effective amount of the compound is between 1-50 mg/kg per day.
6 . The method according to claim 5 , wherein the dose is 2 mg/kg per day.
7 . The method according to claim 5 , wherein the compound is administered as a single daily dose.
8 . The method according to claim 5 , wherein the dose is administered as a plurality of 2-4 daily sub-doses.
9 . The method according to claim 3 , wherein said compound is administered by subcutaneous administration.
10 . The method according to claim 9 , wherein the dose is 0.3-20 mg/kg per day.
11 . The method according to claim 10 , wherein the dose is 0.3-3 mg/kg per day.