Methods for managing adverse events in patients with inflammation

1 . A method of improving a transfusion outcome in a sickle cell disease patient in need of a blood transfusion comprising administering stored oxygen reduced blood to the sickle cell disease patient, wherein the stored oxygen reduced blood comprises red blood cells having increased deformability, wherein the stored oxygen reduced blood has an oxygen saturation of 20% or less during a storage period, wherein the increased deformability is compared to conventionally stored blood stored for an identical storage period, and wherein the improved transfusion outcome comprises reduced occurrence of dactylitis, reduced occurrence of pain crises, reduced complications from anemia, reduced occurrence of infection, reduced spleen damage, reduced risk of stroke, or any combination thereof compared to a sickle cell disease patient having been administered conventionally stored blood stored for an identical storage period.

2 . The method of claim 1 , wherein the sickle cell disease is sickle cell anemia.

3 . The method of claim 1 , wherein the sickle cell disease is sickle cell crisis.

4 . The method of claim 1 , wherein the sickle cell disease is selected from the group consisting of hemoglobin SS (HbSS), hemoglobin SC (HbSC), hemoglobin S beta thalassemia+(HbSB+), hemoglobin S (beta-zero) thalassemia (HbSB), hemoglobin SD (HbSD), hemoglobin SE (HbSE), and hemoglobin SO (HbSO).

5 . The method of claim 1 , wherein the sickle cell disease patient experiences an improved recovery at 24 hours after the administration compared to a sickle cell disease patient having been administered conventionally stored blood stored for an identical time period, and wherein the improved recovery is maintenance of a normal hematocrit level.

6 . The method of claim 1 , wherein the increased deformability compared to conventionally stored blood is when the stored oxygen reduced blood is in the presence of sickle cell plasma.

7 . The method of claim 1 , further comprising reducing carbon dioxide in the stored oxygen reduced blood.

8 . The method of claim 1 , wherein the complications from anemia are selected from the group consisting of fatigue, irritability, dizziness, difficulty breathing, pale skin color, jaundice, slow growth, and delayed puberty.

9 . The method of claim 1 , wherein the spleen damage is splenic sequestration or splenic enlargement.