Mixed Bifidobacterium strain with excellent productivity and anti-inflammatory activity, and uses thereof
Provided is a mixed strain with both excellent anti-inflammatory activity and excellent productivity, including Bifidobacterium animalis subsp. lactis LM1017 (Accession No. KCCM12629P), Bifidobacterium breve LM1092 (Accession No. KCCM13464P), Bifidobacterium longum LM1024 (Accession No. KCCM12919P), and Bifidobacterium bifidum LM1108 (Accession No. KCCM13463P). The strain provided herein has an excellent commercial viability of probiotics.
1 . A mixed strain with both excellent anti-inflammatory activity and excellent productivity, comprising:
Bifidobacterium animalis subsp. lactis LM1017 deposited with the Korean Culture Center of Microorganisms under Accession No. KCCM12629P;
Bifidobacterium breve LM1092 deposited with the Korean Culture Center of Microorganisms under Accession No. KCCM13464P;
Bifidobacterium longum LM1024 deposited with the Korean Culture Center of Microorganisms under Accession No. KCCM12919P; and
Bifidobacterium bifidum LM1108 deposited with the Korean Culture Center of Microorganisms under Accession No. KCCM13463P,
wherein a mixing ratio of the mixed strain is 32:1 to 1:32 based on “LM1017 and LM1092”:“LM1024 and LM1108”.
2 . The mixed strain of claim 1 ,
wherein the anti-inflammatory activity includes the inhibition of nitric oxide production.
3 . An anti-inflammatory composition containing the mixed strain of claim 1 , a culture thereof, a lysate thereof, an extract thereof, or a combination thereof as an active ingredient.
4 . An anti-inflammatory food composition containing the mixed strain of claim 1 , a culture thereof, a lysate thereof, and an extract thereof, or a combination thereof as an active ingredient.
5 . An anti-inflammatory health functional food composition containing the mixed strain of claim 1 , a culture thereof, a lysate thereof, an extract thereof, or a combination thereof as an active ingredient.
6 . An anti-inflammatory pharmaceutical composition containing the mixed strain of claim 1 , a culture thereof, a lysate thereof, an extract thereof, or a combination thereof as an active ingredient.
7 . A method of improving anti-inflammatory activity, comprising:
a process of administering to a subject in need thereof the mixed strain of claim 1 , a culture thereof, a lysate thereof, an extract thereof, or a combination thereof.