Microorganism with high tripeptide productivity and use thereof
The present invention relates to a Candida utilis strain having high tripeptide-producing ability and/or alcohol lyase activity and its use.
1 . A method for increasing glutathione production, comprising culturing a Candida utilis strain having alcohol dehydrogenase (ADH) activity, and alcohol tolerance, and glutathione-producing ability,
wherein the Candida utilis strain has an accession number KCCM 12777P.
2 . The method of claim 1 , wherein the culturing the strain is performed by using sucrose or glucose as a carbon source.
3 . The method of claim 1 , wherein the culturing of strain is performed by adjusting a carbon source supply rate with measuring an ethanol content in fermentation solution.
4 . The method according to claim 1 , wherein the strain is cultured with adding cysteine.
5 . The method of claim 1 , wherein the strain has an ADH activity of 0.18 mU/ml or higher per cell dry weight (g), and a glutathione production of 0.8% by weight or more per cell dry weight (g).
6 . The method of claim 1 , wherein the strain exhibits alcohol tolerance and is capable of growing under ethanol concentration of 2 to 15% (v/v).