Methods and compositions for treating chronic lung diseases
The present invention provides, among other things, methods and compositions for treating Chronic Lung Disease (CLD), comprising administering to a subject in need of treatment a composition comprising insulin-like growth factor-1 (IGF-1) or an agonist or an analog thereof.
1 . A method of treating Chronic Lung Disease comprising administering to a premature infant a composition comprising an equimolar complex of insulin-like growth factor-I (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), wherein the complex is administered by continuous intravenous infusion at a dosage of complex of about 400 micrograms/kg/24 hours from birth to post-menstrual age of about 24 to 34 weeks.
2 . The method of claim 1 , wherein the infant was prematurely born by at least 1 week, 2 weeks, 3 weeks, 4 weeks, 1 month, 2 months, or 3 months.
3 . The method of claim 1 , wherein the complex is administered from the time of birth up to PMA of about 28 to 32 weeks.
4 . The method of claim 1 , wherein the complex is administered from the time of birth up to PMA of about 29 weeks plus 6 days.
5 . The method of claim 1 , wherein the IGF-1, or IGFBP-3 or both are recombinantly produced.
6 . The method of claim 1 , wherein Chronic Lung Disease is Bronchopulmonary dysplasia (BPD).