Biocompatible polymer, biocompatible compositions, sol or gel, and injectable composition
Provided is a biocompatible composition or the like that assists cells in the repair of a damaged tissue in a joint cavity. The biocompatible composition or the like according to the disclosure includes a biocompatible polymer having a substituent that adheres or binds to cells and/or a soft tissue in a joint cavity.
1 . A biocompatible composition comprising:
a mesh structure; and
at least one biocompatible polymer, the biocompatible polymer comprising
at least one substituent group configured to adhere or bind to either a soft tissue in a joint cavity or a cell, wherein
the substituent group configured to adhere or bind to either a soft tissue in a joint cavity or a cell is one or more substituent groups selected from the group consisting of a 4-hydroxyphenyl group, a 3,4-dihydroxyphenyl group, a 3,4,5-trihydroxyphenyl group, and a cell adhesion protein derivative.
2 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises:
a substituent group that adheres to a cell; and
a substituent group that binds to a soft tissue in a joint cavity.
3 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises a plurality of types of monomer units having different in vivo decomposition rates.
4 . The biocompatible composition according to claim 1 , wherein, as the at least one biocompatible polymer, a plurality of types of biocompatible polymers having different in vivo decomposition rates is comprised.
5 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises a substituent group that improves solubility of the biocompatible polymer in a neutral solution.
6 . The biocompatible composition according to claim 5 , wherein the substituent group that improves the solubility of the biocompatible polymer in a neutral solution is one or more substituents selected from the group consisting of a succinyl group, a 4-hydroxyphenyl group, a 3,4-dihydroxyphenyl group, a 3,4,5-trihydroxyphenyl group, and polyethylene glycol.
7 . The biocompatible composition according to claim 1 , further comprising a solvent or dispersion medium, wherein a liquid property of the biocompatible composition is neutral.
8 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises a mucopolysaccharide as a main backbone.
9 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises a chitosan backbone and/or a hyaluronic acid backbone.
10 . The biocompatible composition according to claim 1 , wherein the at least one biocompatible polymer comprises a chitosan backbone and a hyaluronic acid backbone.
11 . The biocompatible composition according to claim 10 , wherein the chitosan backbone and the hyaluronic acid backbone are crosslinked by a hydrolyzable functional group.
12 . The biocompatible composition according to claim 10 , wherein the chitosan backbone and the hyaluronic acid backbone are crosslinked by a Schiff base.
13 . The biocompatible composition according to claim 10 , the at least one biocompatible polymer comprising:
a first polymer having a first ratio of the chitosan backbone to the hyaluronic acid backbone; and
a second polymer having a second ratio of the chitosan backbone to the hyaluronic acid backbone, the second ratio not equal to the first ratio.
14 . The biocompatible composition according to claim 1 , wherein the mesh structure has a gradient in a size of a mesh.
15 . A sol orgel comprising:
a biocompatible composition described in claim 1 ; and
a dispersion medium.