Fiber membrane and preparation method and use thereof
The present disclosure provides a fiber membrane and a preparation method and use thereof, and belongs to the field of biological materials. The fiber membrane includes a fiber with a core-shell structure, where a core of the fiber includes simvastatin and a first spinnable polymer, and a shell of the fiber includes hydroxyapatite and a second spinnable polymer. In the fiber, a release of the simvastatin mainly depends on a rate of water invasion. After water invades the fiber, the simvastatin in the fiber leaves the fiber with the diffusion of water. In the present disclosure, a barrier function of the shell prevents moisture from entering the core. Therefore, the simvastatin in the core cannot leave the fiber with the diffusion of water molecules in an early stage, and a release rate of drugs is slowed down in the early stage, thereby controlling sustained release of the drugs.
1 . A preparation method of a fiber membrane, the fiber membrane comprising a fiber with a core-shell structure, wherein a core of the fiber comprises simvastatin and a first spinnable polymer, and a shell of the fiber comprises hydroxyapatite and a second spinnable polymer, the method comprising the following steps:
conducting coaxial electrospinning on a core spinning solution and a shell spinning solution to obtain the fiber membrane; wherein
the core spinning solution comprises the simvastatin and the first spinnable polymer;
the shell spinning solution comprises the hydroxyapatite and the second spinnable polymer,
the first spinnable polymer and the second spinnable polymer each are polycaprolactone,
wherein the core spinning solution comprises 5 g/L to 20 g/L of the simvastatin and 100 g/L to 150 g/L of the first spinnable polymer by concentration;
the coaxial electrospinning is conducted at a voltage of 7.5 kV to 8.5 kV with a spinning nozzle and a collector spaced apart by 15 cm;
the core spinning solution is added at a flow rate of 1.5 mL/h, and the shell spinning solution is added at a flow rate of 1.0 mL/h; and
the core spinning solution comprises an organic solvent including hexafluoroisopropanol, wherein the core spinning solution is prepared by mixing the simvastatin, the first spinnable polymer, and the organic solvent.
2 . The preparation method according to claim 1 , wherein the shell spinning solution comprises 5 g/L to 15 g/L of the hydroxyapatite and 70 g/L to 120 g/L of the second spinnable polymer by concentration.
3 . The preparation method according to claim 1 , wherein the coaxial electrospinning is conducted at 25° C. to 40° C. with an environmental humidity of 40% to 50%.