IP Library Granted Patent US 12,678,572
Granted Patent B2
US 12,678,572 · App. 17/923,920 · Granted Jul 14, 2026

Method for estimating inhale dose of a person

Inventors: Yu-Chung Hsu (Taoyuan City, TW); Chien-Hua Lin (Taoyuan City, TW); Hsin-Hua Tseng (Taoyuan City, TW); Yi-Shou Chang (Taoyuan City, TW); Jo-Ling Wu (Taoyuan City, TW); Hui-Ling Lin (Taoyuan City, TW)
Assignee: MICROBASE TECHNOLOGY CORP.
A61M15/0065G16H20/13A61M11/005A61M15/0021A61M15/0085A61M15/009A61M2016/0015A61M2016/0027A61M2016/003A61M16/0833A61M2205/7518A61M2209/02A61M2230/40
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Quick Facts
Patent No.
US 12,678,572
App. No.
17/923,920
Granted
Jul 14, 2026
Kind
B2
Abstract

A method for estimating an inhale dose when a drug is delivered to a person using an inhaler is disclosed. A predicted inhale dose (PID) of the drug is estimated based on at least one first-type parameter and at least one second-type parameter. The first-type parameter is related to a breath pattern of the person, and the second-type parameter is related to the inhaler.

Claims (40)

1 . A method for estimating an inhale dose when a drug is delivered to a person using an inhaler, the method comprising:

obtaining, by an analyzer from a breathing module, a first-type parameter related to a breath pattern of the person when the drug is delivered to the person through the inhaler;

obtaining, by the analyzer, a second-type parameter related to the inhaler;

estimating, by the analyzer, a predicted inhale dose of the drug after the drug is delivered to the person through the inhaler for a period of time, based on the first-type parameter and the second-type parameter; and

showing the predicted inhale dose upon the predicted inhale dose being estimated by the analyzer, wherein the predicted inhale dose is estimated according to the following formula:

PID =( TD−RC )*( I /( E+I ))− DP+RP

wherein TD is a total drug amount in an aerosol generator of the inhaler and obtained from the aerosol generator, RC is a drug residue amount in the aerosol generator and obtained from the aerosol generator, I is an inspiratory time of the person and derived from the breath pattern, E is an expiratory time of the person and derived from the breath pattern, DP is a drug deposit in an inlet path of the inhaler and included in the second-type parameter, and RP is a drug reserve in an outlet path of the inhaler and included in the second-type parameter.

2 . The method of claim 1 , wherein the first-type parameter includes an inspiratory time of the person or an expiratory time of the person.

3 . The method of claim 1 , wherein the first-type parameter is obtained by measuring the breath pattern of the person.

4 . The method of claim 1 , wherein the second-type parameter is obtained from a look-up table according to a type of the inhaler.

5 . An apparatus for estimating an inhale dose when a drug is delivered to a person using an inhaler, the apparatus comprising:

a processor; and

a memory storing instructions thereon, wherein the processor is capable of executing the instructions to perform the steps of:

obtaining, from a breathing module, a first-type parameter related to a breath pattern of the person when the drug is delivered to the person through the inhaler;

obtaining a second-type parameter related to the inhaler;

estimating a predicted inhale dose of the drug after the drug is delivered to the person through the inhaler for a period of time, based on the first-type parameter and the second-type parameter; and

showing the predicted inhale dose upon the predicted inhale dose being estimated by the analyzer, wherein the predicted inhale dose is estimated according to the following formula:

PID =( TD−RC )*( I /( E+I ))− DP+RP

wherein TD is a total drug amount in an aerosol generator of the inhaler and is obtained from the aerosol generator, RC is a drug residue amount in the aerosol generator and is obtained from the aerosol generator, I is an inspiratory time of the person and is derived from the breath pattern, E is an expiratory time of the person and is derived from the breath pattern, DP is a drug deposit in an inlet path of the inhaler and is included in the second-type parameter, and RP is a drug reserve in an outlet path of the inhaler and is included in the second-type parameter.

6 . The apparatus of claim 5 , wherein the first-type parameter includes an inspiratory time of the person or an expiratory time of the person.

7 . The apparatus of claim 5 , wherein the first-type parameter is obtained by measuring the breath pattern of the person.

8 . The apparatus of claim 5 , wherein the second-type parameter is obtained from a look-up table according to a type of the inhaler.

9 . A non-transitory storage medium with instructions stored thereon for estimating an inhale dose when a drug is delivered to a person using an inhaler, wherein a processor is capable of executing the instructions to perform the following steps:

obtaining, by an analyzer from a breathing module, a first-type parameter related to a breath pattern of the person when the drug is delivered to the person through the inhaler;

obtaining, by the analyzer, a second-type parameter related to the inhaler;

estimating, by the analyzer, a predicted inhale dose of the drug after the drug is delivered to the person through the inhaler for a period of time, based on the first-type parameter and the second-type parameter; and

showing the predicted inhale dose upon the predicted inhale dose being estimated by the analyzer, wherein the predicted inhale dose is estimated according to the following formula:

PID =( TD−RC )*( I /( E+I ))− DP+RP

wherein TD is a total drug amount in an aerosol generator of the inhaler and is obtained from the aerosol generator, RC is a drug residue amount in the aerosol generator and is obtained from the aerosol generator, I is an inspiratory time of the person and is derived from the breath pattern, E is an expiratory time of the person and is derived from the breath pattern, DP is a drug deposit in an inlet path of the inhaler and is included in the second-type parameter, and RP is a drug reserve in an outlet path of the inhaler and is included in the second-type parameter.

10 . The non-transitory storage medium of claim 9 , wherein the first-type parameter includes an inspiratory time of the person or an expiratory time of the person.

11 . The non-transitory storage medium of claim 9 , wherein the first-type parameter is obtained by measuring the breath pattern of the person.

12 . The non-transitory storage medium of claim 9 , wherein the second- type parameter is obtained from a look-up table according to a type of the inhaler.

13 . A method for delivering a drug to a person using an inhaler, comprising:

inputting, to an analyzer, information related to a type of the inhaler;

measuring, by a breathing module, a breath pattern of the person; and

determining an inhale dose according to a predicted inhale dose of the drug shown by the analyzer after the drug is delivered to the person through the inhaler for a period of time, wherein the predicted inhale dose of the drug is estimated by the analyzer based on a first-type parameter related to the breath pattern of the person and a second-type parameter related to the inhaler, wherein the predicted inhale dose is estimated according to the following formula:

PID =( TD−RC )*( I /( E+I ))− DP+RP

wherein TD is a total drug amount in an aerosol generator of the inhaler and is obtained from the aerosol generator, RC is a drug residue amount in the aerosol generator and is obtained from the aerosol generator, I is an inspiratory time of the person and is derived from the breath pattern, E is an expiratory time of the person and is derived from the breath pattern, DP is a drug deposit in an inlet path of the inhaler and is included in the second-type parameter, and RP is a drug reserve in an outlet path of the inhaler and is included in the second- type parameter.

14 . The method of claim 13 , wherein the first-type parameter includes an inspiratory time of the person or an expiratory time of the person.

15 . The method of claim 13 , wherein the second-type parameter is obtained from a look-up table according to the type of the inhaler.