Intraurethral medication dosage form and device
View Patent ↗An intraurethral dosage form of liquid or gel medication for men or women. In one embodiment, an applicator provides advantages in its use, facilitating the application of pharmaceutical compositions directly into the urethral channel and providing fast local effect without substantial risk. The invention provides a dosage form and route of administration for several medications, being particularly useful for the application of anti-inflammatory and/or anesthetic medications, for the treatment of female cystitis, for modulating female genital sensitivity and/or for modulating the erectile function in man, being an advantageous dosage form alternative to the oral or injectable administration of medications or even the intraurethral administration of pills.
1 . A system for intraurethral medication dosage comprising an intraurethral applicator device and a single dose of liquid or gel pharmaceutical composition comprising one or more anti-inflammatories, one or more anesthetics, one or more active ingredients for the treatment of female cystitis, one or more active ingredients to modulate female genital sensitivity, one or more active ingredients to modulate erectile function in men, or combinations thereof, the single dose being administered by the intraurethral applicator device comprising:
two concave and opposite faces ( 11 , 12 ) dockable, configured to be held by finger and attached to each other, defining an interior space of a receptacle ( 10 ) housing a syringe that is disposable and made of plastic,
wherein,
the syringe is configured for needle-free intraurethral medication;
one of the concave faces ( 11 ) comprises a groove ( 13 ) positioned on an internal surface of the interior space of the receptacle ( 10 ), where a back part of the syringe enters the groove ( 13 ) to be fitted into the interior space of the receptacle ( 10 ), wherein the back part of the syringe receives a rod ( 14 ) that is configured to displace a plunger ( 15 ) of the syringe, releasing the single dose through a tip of the syringe; and
the groove ( 13 ) comprises two walls, each of the walls having a curved region, wherein the back part of the syringe is fitted between the walls on the curved region.
2 . The system for intraurethral medication dosage according to claim 1 , further comprising one or more of the following aspects: the plastic syringe is of the extended Luer-Slip type; a cap ( 17 ) for the syringe; a limiter ( 20 ); four latches ( 19 ).
3 . The system for intraurethral medication dosage according to claim 1 , further comprising a hollow region ( 16 ) on another one of the concave faces ( 12 ).
4 . The system for intraurethral medication dosage according to claim 1 , wherein one or both of the concave faces are provided with external parts comprising shoulders ( 18 ).
5 . The system for intraurethral medication dosage according to claim 1 , wherein the syringe comprises the tip disposed in a forward part of the syringe, outside the receptacle ( 10 ), and a barrel disposed inside the receptacle ( 10 ), wherein the barrel and the tip form a single body.
6 . An intraurethral medication dosage device comprising:
two concave and opposite faces ( 11 , 12 ) dockable, configured to be held by finger and attached to each other, defining an interior space of a receptacle ( 10 ) housing a syringe that is disposable, made of plastic, and configured for needle-free intraurethral medication,
wherein one of the concave faces ( 11 ) comprises a groove ( 13 ) positioned on an internal surface of the interior space of the receptacle ( 10 ), where a back part of the syringe enters the groove ( 13 ) to be fitted into the interior space of the receptacle ( 10 ), wherein the back part of the syringe receives a rod ( 14 ) that is configured to displace a plunger of the syringe, releasing the single dose thorough a tip of the syringe, and
the groove ( 13 ) comprises two walls, each of the walls having a curved region, wherein the back part of the syringe is fitted between the walls and on the curved region.
7 . The device according to claim 6 , characterized in thatwherein another one of the concave faces ( 12 ) comprises a hollow region ( 16 ) providing a view of the contents of the syringe inside the receptacle ( 10 ).
8 . The device according to claim 7 , further comprising a travel limiter for use in a female urethra ( 20 ).
9 . The device according to claim 6 , wherein the syringe comprises the tip disposed in a forward part of the syringe, outside the receptacle ( 10 ), and a barrel disposed inside the receptacle ( 10 ), wherein the barrel and the tip form a single body.
10 . A method for dosing medication from an intraurethral dosage applicator device, characterized for comprising an administration of a single dose of pharmaceutical composition in liquid or gel form comprising one or more anti-inflammatories, one or more anesthetics, one or more active ingredients for the treatment of female cystitis, one or more active ingredients to modulate female genital sensitivity, one or more active ingredients to modulate erectile function in men, or combinations thereof, wherein the device comprises:
two concave and opposite faces ( 11 , 12 ) dockable, configured to be held by finger and attached to each other, defining an interior space of a receptacle ( 10 ) housing a syringe that is disposable and configured for needle-free intraurethral medication, wherein one of the concave faces ( 11 ) comprises a groove ( 13 ) positioned on an internal surface of the interior space of the receptacle ( 10 ), where a back part of the syringe enters the groove ( 13 ) to be fitted into the interior space of the receptacle ( 10 ), wherein the back part of the syringe receives a rod ( 14 ) and is connected to a plunger ( 15 ) of the syringe,
wherein the method comprises a step of actuation of the rod ( 14 ) that displaces the plunger ( 15 ) of the syringe, which contains the single dose of the medication, dispensing the medication through a tip of the syringe; and
the groove ( 13 ) comprises two walls, each of the walls having a curved region, wherein the back part of the syringe is fitted between the walls on the curved region.
11 . The method according to claim 10 , further comprising a step of:
positioning the syringe, previously filled with the single dose of the drug and/or fillable at a time of application, in the receptacle ( 10 ) of the device.