Method and device for laboratory formulation and chemical vending
View Patent ↗An automatic chemical solution formulating device combines and mixes stored solids and liquids into user specified formulations and dispenses those formulations into containers. Chemical solids are stored in cartridges of material separated into predetermined dosages (for example in reeled blister packs), avoiding the need for weighing during formulation. Elements include user interface, computer-controlled automated loading and unloading port for reagent-containing cartridges, cartridge conveyor system, reader for identifying cartridges, blister-pack strip drive system, punching mechanism to release reagents, portioning chamber to mix solvent with solids or liquids with optional portioning, accommodating formulation delivery port, position sensors, liquid flow measuring devices, liquid and gas pumps and valves, and label printer. The combination of these elements allows high-speed formulation and dispensing of user-specified formulations.
1 . A method of automated laboratory formulation production comprising:
a step of maintaining a plurality of cartridges wherein each cartridge contains a plurality of encapsulated or pelletized, pre-measured quanta of a particular reagent, wherein said quanta comprise individual discrete solid units in non-blister pack form, but every cartridge does not contain the same reagent;
a step of receiving a desired formulation defining a chemical composition and total volume from a user;
a step of automated computing to convert the desired formulation and volume to specific numbers of said pre-measured quanta;
a step of ejecting said specific numbers of said pre-measured quanta;
a step of mixing said specific numbers of said pre-measured quanta; and
a step to produce said desired formulation devoid of a step to weigh or measure said reagents.
2 . A method as in claim 1 where in said desired formulation includes at least one solid reagent and said step of mixing comprises at least one liquid.
3 . A method as in claim 1 further comprising:
a step of implementing a Duplicate Cartridge Protocol by maintaining more than one of each said cartridge.
4 . A method as in claim 1 further comprising:
a step of synthesizing formulation pH by computing and ejecting a computed number of quanta of pH-affecting reagents devoid of a step of pH measurement.
5 . A method as in claim 1 further comprising:
a step of labeling each said cartridge with assay information as to the dosage of each of said quanta contained therein in a machine-readable format.
6 . A method as in claim 1 further comprising:
a step of writing and storing updated information as to the number of remaining quanta in each said cartridge concomitant with said step of ejecting.
7 . A device disposed to produce a user-specified formulation of at least one of: a liquid, a solution, a mixture, and a suspension, comprising:
a plurality of tagged cartridges each cartridge containing multiple individual quanta of a particular reagent;
a computer to automatically calculate the number of quanta needed to synthesize said user-specified formulation with appropriate concentrations for a desired volume specified by the user;
a dispenser disposed to automatically eject any whole number of quanta of reagents from said cartridges as specified by said computer;
an enclosure; and
an output disposed to allow removal of said formulation from said device.
8 . A device as in claim 7 disposed with an inventory management system capable of automatically maintaining a Duplicate Cartridge Protocol for multiple reagents.
9 . A device as in claim 7 wherein a portioning chamber is disposed to fractionate at least one of said quanta to be added to the formulation.
10 . A device as in claim 7 wherein said output is compliant to fit the input of various different vessels.
11 . A method of automated laboratory formulation production which comprises:
providing a plurality of distinct pre-quantized reagents in non-blister pack form, contained in a plurality of separate cartridges;
receiving a user input specifying a desired chemical composition and a target volume;
selectively ejecting a computed number of quanta of reagents from at least one of said cartridges;
providing at least one liquid solvent;
ejecting a computed quantity of said at least one liquid solvent; and
mixing said computed number of quanta of reagents with said liquid solvent.
12 . A method as in claim 11 further comprising a step where a desired pH of said formulation can be synthesized by dispensing a computed number of reagent quanta without the need for pH measurement.
13 . The method as in claim 11 , further comprising steps of:
selectively dispensing said quanta into a mixing chamber;
selectively dispensing said liquid solvent into said mixing chamber;
mixing contents of said mixing chamber; and
discharging contents of said mixing chamber via an output port.
14 . The method as in claim 11 further comprising steps to improve the accuracy of said formulation wherein:
a portion of the contents of a mixing chamber is computed;
only said portion is discharged to a port; and
an additional amount of liquid solvent is computed and dispensed to dilute said portion.
15 . A method as in claim 11 further comprising:
labeling each of said cartridges with assay information as to the dosage of each of said quanta contained therein in a machine-readable format.
16 . A method as in claim 11 further comprising:
writing and storing updated information as to the number of remaining quanta in each of said cartridges concomitant with said step of ejecting.