Modified isoindolinones as glucosylceramide synthase inhibitors

1 . A compound of the formula I:

or a pharmaceutically acceptable salt thereof, wherein

R 1 is hydrogen, C1-C4 alkyl, C1-C4 fluoroalkyl, hydroxy, —C1-C4alkylOH, or halo;

Each X is independently —CR a —, or N;

R a is hydrogen, C1-C4 alkyl, C1-C4 fluoroalkyl, hydroxy, or halo;

is phenyl, 2,3-dihydro-1H-benzo[d]imidazolyl, benzo[d][1,3]dioxolyl, 1,2,3,4-tetrahydroisoquinolinyl, quinoxalinyl, phenylcarbonylamino, isoindolinyl, (benzo[d][1,3]dioxolyl)carbonylamino, quinuclidinyloxycarbonylamino, pyridylcarbonylamino, quinolinylcarbonylamino, (2,3-dihydro-1H-cyclopenta[b]quinolinyl)carbonylamino, (2,3-dihydrofuro[2,3-b]pyridinyl)carbonylamino, (dihydrobenzofuranyl)carbonylamino, (indolyl)carbonylamino, (indazolyl)carbonylamino, (2,3-dihydrobenzofuranyl)cabonylamino, (1H-pyrrolo[2,3-b]pyridinyl)carbonylamino, (2,3-dihydro[1,4]dioxino[2,3-b]pyridinyl)carbonylamino, (2,3-dihydro-1H-indenyl)carbonylamino, (6,7-dihydro-5H-cyclopenta[b]pyridyl)ethenyl, (6,7-dihydro-5H-cyclopenta[b]pyridyl)carbonylamino, (benzo[d]thiazolyl)carbonylamino, (6,7-dihydro-5H-cyclopenta[b]pyridyl)ethenyl, (6,7-dihydro-5H-cyclopenta[b]pyridyl)ethyl, (6,7-dihydro-5H-cyclopenta[b]pyridyl)oxymethyl, (6,7-dihydro-5H-cyclopenta[b]pyridyl)methoxy, (6,7-dihydro-5H-cyclopenta[b]pyridyl)ethynyl, phenylethenyl, ([1,3]dioxolo[4,5-b]pyridyl)ethenyl, ([1,3]dioxolo[4,5-b]pyridyl)ethyl, ([1,3]dioxolo[4,5-b]pyridyl)carbonylamino, ([1,3]dioxolo[4,5-b]pyridyl)oxymethyl, ([1,3]dioxolo[4,5-b]pyridyl)methoxy, ([1,3]dioxolo[4,5-b]pyridyl)aminomethyl, (pyrazolo[1,5-a]pyridyl)carbonylamino, (pyrazolo[4,3-b]pyridyl)carbonylamino, or naphthyridinylcarbonylamino;

each R 2 is independently selected from fluoro, chloro, bromo, cyano, trifluromethyl, 2,2,2-trifluroethyl, methoxy, ethoxy, propoxy, hydroxy, methyl, ethyl, propyl, isopropyl, butyl, oxo, phenyl, azaindolyl, benzoimidazolyl, benzisoxazolyl, benzofuranyl, benzofurazanyl, benzopyrazolyl, benzotriazolyl, benzothiophenyl, benzothiazolyl, benzo[d]isothiazole, benzoxazolyl, carbazolyl, carbolinyl, cinnolinyl, furanyl, imidazolyl, indolinyl, indolyl, indolazinyl, indazolyl, isobenzofuranyl, isoindolyl, isoquinolyl, isothiazolyl, isoxazolyl, naphthpyridinyl, oxadiazolyl, oxazolyl, oxazoline, isoxazoline, pyranyl, pyrazinyl, pyrazolyl, pyrrolyl, pyrazolopyrimidinyl, pyridazinyl, pyridyl, pyrimidyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, tetrazolyl, tetrazolopyridyl, thiadiazolyl, 5H-pyrrolo[3,4-b]pyridine, thiazolyl, thienyl, triazolyl, triazinyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl, isoquinolinyl, and oxazolyl, —(C0-C4 alkyl)O(C1-C4 fluoroalkyl), wherein each R 2 is substituted with 0, 1, or 2 R 5 substituents, each R 5 is independently C1-C6alkyl, halo, hydroxy, or —(C1-C4 alkyl)OH;

is 2-hydroxy-2-methylpropyl, 1-methyl-2-hydroxy-2-methylpropyl, cyclopentylethyl, 1-ethyl-2-hydroxy-2-methylpropyl, 2-hydroxyethyl, oxetanylmethyl, quinuclidinylethyl, cyclopropyl-2-methylpropyl, cyclopropylmethyl, methylisobutyl, cyclobutylmethyl, 1-cyclopropylethyl, cyclohexyl, phenyl, isobutyl, or oxetanylmethyl;

each R 3 is independently selected from trifluoromethyl, methyl, ethyl, hydroxy, methoxy, 2-hydroxy-propyl, hydroxymethyl, cyclopropyl, methoxymethyl and fluoro; and

R 4 is hydrogen, C1-C4 alkyl, or hydroxy.

2 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy, hydroxy, or halo.

3 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl, ethyl, propyl, isopropyl, trifluoromethyl, —OH, fluoro, chloro, or bromo.

4 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein each R 2 independently is selected from fluoro, chloro, bromo, cyano, trifluromethyl, methoxy, ethoxy, 2,2,2-trifluoroethoxy, trifluoroethoxy, hydroxy, methyl, oxo, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazolyl, pyridazinyl, pyridyl, triazolyl, and oxazolyl, wherein each R 2 is substituted with 0, 1, or 2 R 5 substituents.

5 . The compound of claim 4 or a pharmaceutically acceptable salt thereof, wherein R 5 independently is selected from methyl, ethyl, propyl, isopropyl, butyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, methoxy, ethoxy, and propoxy.

6 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein at least one X is N.

7 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein each X is —CR a —.

8 . The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R a is hydrogen, methyl, hydroxy, F, or Cl.

9 . A compound of claim 1 , or a pharmaceutically acceptable salt thereof, selected from:

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,4-difluorostyryl)isoindolin-1-one;

(R)-(E)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,4-difluorostyryl)isoindolin-1-one;

(S)-(E)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,4-difluorostyryl)isoindolin-1-one;

7-(4-(1,3,4-oxadiazol-2-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(4-(1,3,4-oxadiazol-2-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-5-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one;

5-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

3-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methoxybenzonitrile;

(R)-3-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methoxybenzonitrile;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

7-(3-chloro-5-methoxyphenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(3-chloro-5-methoxyphenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(6-fluoro-3-methyl-1H-indazol-5-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(6-fluoro-3-methyl-1H-indazol-5-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-1H-indazol-5-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-1H-indazol-5-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)isoindolin-1-one;

(R)-7-(4-(2H-1,2,3-triazol-2-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

7-(4-(2H-1,2,3-triazol-2-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(6-methylpyridazin-3-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(6-methylpyridazin-3-yl)phenyl)isoindolin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(6-methylpyridazin-3-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(6-methylpyridazin-3-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3,4-dimethoxyphenyl)isoindolin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3,4-dimethoxyphenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3,4-dimethoxyphenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,6-dimethylpyridin-4-yl)isoindolin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,6-dimethylpyridin-4-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2,6-dimethylpyridin-4-yl)isoindolin-1-one;

2-((R)-1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-((S)-1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(3-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(3-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-2′-methyl-[4,5′-biisoindoline]-1′,3-dione;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-2′-methyl-[4,5′-biisoindoline]-1′,3-dione;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(3-methylisoxazol-5-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(4-(3-methylisoxazol-5-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-fluoro-7-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one;

(R)-3-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-5-methoxybenzonitrile;

(S)-3-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-5-methoxybenzonitrile;

3-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-5-methoxybenzonitrile;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one;

(R)-6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(2-fluoro-5-methyl-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-(2-fluoro-5-methyl-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

(R)-4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-5-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(S)-5-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

5-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-6-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

6-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

4-chloro-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(S)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(R)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(S)-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(R)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(S)-6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

6-fluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5,6-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5,6-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(3-hydroxy-3-methylbutan-2-yl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(3-hydroxy-3-methylbutan-2-yl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(cis)-2-(2-(3-hydroxycyclopentyl)ethyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(trans)-2-(2-(3-hydroxycyclopentyl)ethyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(2-(3-hydroxycyclopentyl)ethyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-[(1R)-1-ethyl-2-hydroxy-2-methyl-propyl]-7-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]isoindolin-1-one;

2-[(1-ethyl-2-hydroxy-2-methyl-propyl]-7-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxyethyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxyethyl)-7-(2-(2,2,2-trifluoroethoxy)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxyethyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxyethyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(cyclopropyl(3-hydroxyoxetan-3-yl)methyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(S)-2-(cyclopropyl(3-hydroxyoxetan-3-yl)methyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(cyclopropyl(3-hydroxyoxetan-3-yl)methyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-7-(4-fluorophenyl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

(S)-7-(4-fluorophenyl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

7-(4-fluorophenyl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

(R)-2-(2-(quinuclidin-3-yl)ethyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)isoindolin-1-one;

(S)-2-(2-(quinuclidin-3-yl)ethyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)isoindolin-1-one;

2-(2-(quinuclidin-3-yl)ethyl)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)isoindolin-1-one;

(R)-7-(2-methylpyridin-4-yl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

(S)-7-(2-methylpyridin-4-yl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

7-(2-methylpyridin-4-yl)-2-(2-(quinuclidin-3-yl)ethyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)-6-fluoroisoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)-6-fluoroisoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)-4-fluoroisoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)-4-fluoroisoindolin-1-one;

2-(1-cyclopropyl-2-methoxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-methoxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-((R)-1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(S)-2-((R)-1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-4-hydroxy-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-5-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-5-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-((R)-1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(S)-2-((R)-1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-methyl-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-2′-methyl-[4,5′-biisoindoline]-1′,3-dione;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-2′-methyl-[4,5′-biisoindoline]-1′,3-dione;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyloxazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyloxazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-3-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-3-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(5-fluoro-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-3-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(5-fluoro-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-3-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-methoxy-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-methoxy-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

7-(4-(1H-1,2,3-triazol-1-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(4-(1H-1,2,3-triazol-1-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-5-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-5-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-3-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-fluoro-3-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(2,2,2-trifluoroethoxy)pyridin-3-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(2,2,2-trifluoroethoxy)pyridin-3-yl)isoindolin-1-one;

7-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-1,4-dihydroisoquinolin-3 (2H)-one;

(R)-7-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-1,4-dihydroisoquinolin-3 (2H)-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-methoxyquinoxalin-6-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-methoxyquinoxalin-6-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(oxazol-2-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(oxazol-2-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-1H-indazol-3-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-1H-indazol-3-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-3-(trifluoromethyl)-1H-indazol-5-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-methyl-3-(trifluoromethyl)-1H-indazol-5-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)isoindolin-1-one;

7-(3-(1,2,4-oxadiazol-3-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(3-(1,2,4-oxadiazol-3-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

7-(4-(1,2,4-oxadiazol-3-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(4-(1,2,4-oxadiazol-3-yl)phenyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

6-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1-methylindolin-2-one;

(R)-6-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1-methylindolin-2-one;

5-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1-methylindolin-2-one;

(R)-5-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-1-methylindolin-2-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,3-dimethyl-1H-indazol-5-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,6-dimethyl-1H-indazol-5-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1,6-dimethyl-1H-indazol-5-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-(pyridin-4-yl)-1H-pyrazol-4-yl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(1-(pyridin-4-yl)-1H-pyrazol-4-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(3-methylisoxazol-5-yl)phenyl)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(3-methylisoxazol-5-yl)phenyl)isoindolin-1-one;

2-[(1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-(2-methyloxazol-5-yl)phenyl]isoindolin-1-one;

2-[(1R)-1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-(2-methyloxazol-5-yl)phenyl]isoindolin-1-one;

4-chloro-6-[2-[1-cyclopropyl-2-hydroxy-2-methyl-propyl]-3-oxo-isoindolin-4-yl]pyridine-2-carbonitrile;

4-chloro-6-[2-[(1R)-1-cyclopropyl-2-hydroxy-2-methyl-propyl]-3-oxo-isoindolin-4-yl]pyridine-2-carbonitrile;

7-(6-chloro-4-methoxypyridin-2-yl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(6-chloro-4-methoxypyridin-2-yl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

2-[(1R)-1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-(1-methyltriazol-4-yl)phenyl]isoindolin-1-one;

2-[1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-(1-methyltriazol-4-yl)phenyl]isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(isothiazol-4-yl)phenyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(isothiazol-4-yl)phenyl)isoindolin-1-one;

2-[(1R)-1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-[3-(hydroxymethyl)-4-methyl-isoxazol-5-yl]phenyl]isoindolin-1-one;

2-[(1-cyclopropyl-2-hydroxy-2-methyl-propyl]-7-[4-[3-(hydroxymethyl)-4-methyl-isoxazol-5-yl]phenyl]isoindolin-1-one;

6-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-4-methoxypicolinonitrile;

(R)-6-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-4-methoxypicolinonitrile;

N-(2-(Dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

2-Ethoxy-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(R)-2-Ethoxy-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

2-ethoxy-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(R)-2-ethoxy-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

N-(2-(1-cyclobutyl-2-hydroxyethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

(S)-N-(2-(1-cyclobutyl-2-hydroxyethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

(R)-N-(2-(1-cyclobutyl-2-hydroxyethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

N-(2-(1-cyclopropyl-2-hydroxyethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxyethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

2-ethoxy-N-(2-(2-hydroxycyclohexyl)-3-oxoisoindolin-4-yl)benzamide;

2-ethoxy-N-(2-((1R,2S)-2-hydroxycyclohexyl)-3-oxoisoindolin-4-yl)benzamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-2-ethoxybenzamide;

2-ethoxy-N-(2-((1-hydroxycyclobutyl)methyl)-3-oxoisoindolin-4-yl)benzamide;

2-ethoxy-N-(2-((3-hydroxyoxetan-3-yl)methyl)-3-oxoisoindolin-4-yl)benzamide;

2-Ethoxy-N-(3-oxo-2-(quinuclidin-3-yl)isoindolin-4-yl)benzamide;

(R)-2-Ethoxy-N-(3-oxo-2-(quinuclidin-3-yl)isoindolin-4-yl)benzamide;

(S)-2-Ethoxy-N-(3-oxo-2-(quinuclidin-3-yl)isoindolin-4-yl)benzamide;

2-Ethoxy-N-(3-oxo-2-(quinuclidin-2-ylmethyl)isoindolin-4-yl)benzamide; (108)

(R)-2-Ethoxy-N-(3-oxo-2-(quinuclidin-2-ylmethyl)isoindolin-4-yl)benzamide;

(S)-2-Ethoxy-N-(3-oxo-2-(quinuclidin-2-ylmethyl)isoindolin-4-yl)benzamide;

5-Bromo-N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)benzo[d][1,3]dioxole-4-carboxamide;

2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-fluoro-3-methylbenzamide;

(R)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-fluoro-3-methylbenzamide;

(S)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-fluoro-3-methylbenzamide;

6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-fluoro-3-methylbenzamide;

(R)-6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-fluoro-3-methylbenzamide;

(S)-6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-fluoro-3-methylbenzamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-difluoro-6-methoxybenzamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-difluoro-6-methoxybenzamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-difluoro-6-methoxybenzamide;

2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-methylbenzamide;

(R)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-methylbenzamide;

(S)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-methylbenzamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-1H-indene-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-1H-indene-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-1H-indene-4-carboxamide;

2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3,6-difluorobenzamide;

(R)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3,6-difluorobenzamide;

(S)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3,6-difluorobenzamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-(trifluoromethyl)benzamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-(trifluoromethyl)benzamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-(trifluoromethyl)benzamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

6-chloro-N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-methylbenzamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-methylbenzamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-3-fluoro-2-methylbenzamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-3-(trifluoromethyl)benzamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-3-(trifluoromethyl)benzamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-3-(trifluoromethyl)benzamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

6-chloro-2-fluoro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-methylbenzamide;

(R)-6-chloro-2-fluoro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-methylbenzamide;

2,6-dichloro-3-fluoro-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(R)-2,6-dichloro-3-fluoro-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

2,6-dichloro-3-fluoro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(R)-2,6-dichloro-3-fluoro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

3-chloro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-6-(trifluoromethyl)picolinamide;

(R)-3-chloro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-6-(trifluoromethyl)picolinamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-1-methyl-1H-indole-4-carboxamide;

N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-(trifluoromethyl)quinoline-4-carboxamide;

(R)-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-(trifluoromethyl)quinoline-4-carboxamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide;

3-chloro-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-6-(trifluoromethyl)picolinamide;

(R)-3-chloro-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-6-(trifluoromethyl)picolinamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-3-(trifluoromethyl)quinoline-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)benzo[d]thiazole-7-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)benzo[d]thiazole-7-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)benzo[d]thiazole-7-carboxamide;

6-chloro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-(trifluoromethyl)picolinamide;

(R)-6-chloro-N-(2-(1-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)-3-(trifluoromethyl)picolinamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

(S)-N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-3-fluoro-6-methoxy-1,5-naphthyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-methoxyethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-methoxyethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-methoxyethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

6-chloro-N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(S)-6-chloro-N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(R)-2-ethoxy-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)nicotinamide;

2-ethoxy-N-(2-(3-hydroxy-3-methylbutan-2-yl)-3-oxoisoindolin-4-yl)nicotinamide;

3,5-dichloro-N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)isonicotinamide;

(S)-N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(1-cyclopropylethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-7-fluoro-1-oxo-2,3-dihydro-1H-indene-4-carboxamide;

N-(6-chloro-2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-6-fluoroquinoline-4-carboxamide;

N-(2-(dicyclopropylmethyl)-3-oxoisoindolin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide;

N-(2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(7-chloro-2-(cyclopropylmethyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(Cyclopropylmethyl)-6-methyl-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(cyclopropylmethyl)-7-hydroxy-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(Cyclopropylmethyl)-6-methyl-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(Cyclopropylmethyl)-7-hydroxy-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

Quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)carbamate;

N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-7-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(R)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-7-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(S)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-7-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(R)-N-(6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(S)-N-(6-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3,5-dimethylisonicotinamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3,5-dimethylisonicotinamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3,5-dimethylisonicotinamide;

5-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3-methylisonicotinamide;

(R)-5-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3-methylisonicotinamide;

(S)-5-Chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3-methylisonicotinamide;

5-Chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(R)-5-Chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(S)-5-Chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)pyrazolo[1,5-a]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)pyrazolo[1,5-a]pyridine-4-carboxamide;

6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(R)-6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(S)-6-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3-methylisonicotinamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methoxy-3-methylisonicotinamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-6-fluoro-3-oxoisoindolin-4-yl)-2-methyl-2H-indazole-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-8-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dimethoxyisonicotinamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dimethoxyisonicotinamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-2,3-dimethoxyisonicotinamide;

N-(2-(1-cyclopropyl-2-methoxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-methoxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-methoxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

N-(2-((1-hydroxycyclobutyl)methyl)-3-oxoisoindolin-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine-4-carboxamide;

2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-7-yl)-6-fluoro-3-methylbenzamide;

(R)-2-chloro-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-7-yl)-6-fluoro-3-methylbenzamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(R)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(S)-N-(2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

(R)-quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

(S)-quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(R)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

(S)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-5-methyl-2,3-dihydrofuro[2,3-b]pyridine-4-carboxamide;

N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(R)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

(S)-N-(2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-3-oxoisoindolin-4-yl)-6-methyl-[1,3]dioxolo[4,5-b]pyridine-7-carboxamide;

Quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

(R)-Quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

(S)-Quinuclidin-3-yl(2-(4-fluorophenyl)-3-oxoisoindolin-4-yl)(methyl)carbamate;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)vinyl)isoindolin-1-one;

(R)-(E)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)vinyl)isoindolin-1-one;

(S)-(E)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)vinyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethynyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethynyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethynyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)ethyl)isoindolin-1-one;

7-(2-(6-Chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-(E)-7-(2-(6-Chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(S)-(E)-7-(2-(6-Chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)isoindolin-1-one;

(R)-(E)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)isoindolin-1-one;

(S)-(E)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)vinyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

7-(((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)oxy)methyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-(((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)oxy)methyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(S)-7-(((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)oxy)methyl)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(((6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)methyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(((6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)methyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(((6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)methyl)isoindolin-1-one;

7-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)methoxy)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(R)-7-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)methoxy)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

(S)-7-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)methoxy)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)methoxy)isoindolin-1-one;

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)methoxy)isoindolin-1-one;

(S)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-7-((6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)methoxy)isoindolin-1-one;

2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

(R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

(S)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(2-(6-methyl-[1,3]dioxolo[4,5-b]pyridin-7-yl)ethyl)isoindolin-1-one;

5,6-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(R)-5,6-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

(S)-5,6-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-2-(1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl)isoindolin-1-one;

2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4,5-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one; and

(R)-2-(1-cyclopropyl-2-hydroxy-2-methylpropyl)-4,5-difluoro-7-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)isoindolin-1-one.

10 . A pharmaceutical composition comprising an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

11 . The pharmaceutical composition of claim 10 , further comprising one or more additional therapeutic agents.

12 . A method for treatment of lysosomal storage diseases, kidney disease, neurodegenerative disease, diabetes related diseases, or cancers where GSL synthesis is abnormal or overexpression GCS disrupts ceramide-induced apoptosis, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound according to claim 1 .

13 . A method of treatment of Parkinson's Disease, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

14 . A method of treatment of a disease, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a compound of claim 1 , wherein said disease is selected from dementia with Lewy bodies, polycystic kidney disease, renal hypertrophy, diabetes mellitus, obesity, hyperglycemia, hyperinsulemia, leukemia, papillary renal cancer, and thyroid carcinomas.