Radioactive halogen labeling precursor compound
Provided is, as a radioactive halogen labeling precursor compound that is highly reactive and stable, a compound represented by the following general formula (II): wherein R 1 and R 2 each independently represent an alkyl group having 5 to 20 carbon atoms, X 1 and X 2 each independently represent a halogen atom, and R 3 represents a monovalent group derived from a sugar, or the like.
1 . A compound represented by the following general formula (I):
wherein R 1 and R 2 each independently represent an alkyl group having 5 to 20 carbon atoms, X 1 and X 2 each independently represent a halogen atom, and X 3 represents a halogen atom.
2 . The compound according to claim 1 , wherein R 1 and R 2 in the general formula (I) are each an alkyl group having 7 to 11 carbon atoms.
3 . The compound according to claim 1 , wherein X 1 and X 2 in the general formula (I) are each a fluorine atom or a chlorine atom.
4 . A compound represented by the following general formula (II):
wherein R 1 and R 2 each independently represent an alkyl group having 5 to 20 carbon atoms, X 1 and X 2 each independently represent a halogen atom, and R 3 represents (i) a monovalent group derived from a sugar, which is a monovalent group obtained by removing one hydrogen atom in the sugar; (ii) a monovalent group derived from a peptide, which is a monovalent group obtained by removing one hydrogen atom in the peptide; or (iii) a group represented by the following general formula (A) or (B):
wherein L represents a divalent group that functions as a spacer, R 4 represents an aryl group optionally substituted with a substituent, a heteroaryl group optionally substituted with a substituent, or an aminocarbonyl group optionally protected by a protective group, and * represents a bonding site.
5 . The compound according to claim 4 , wherein R 1 and R 2 in the general formula (II) are each an alkyl group having 7 to 11 carbon atoms.
6 . The compound according to claim 4 , wherein X 1 and X 2 in the general formula (II) are each a fluorine atom or a chlorine atom.
7 . The compound according to claim 4 , wherein L in the general formula (A) or (B) is an alkylene group, and one or more —CH 2 — of the alkylene group are optionally replaced with —O— or a phenylene group.
8 . The compound according to claim 4 , wherein R 4 in the general formula (A) or (B) is a 4-[2,3-bis(tert-butoxycarbonyl)guanidinomethyl]phenyl group, a naphthalen-2-yl group, a 2-nitro-1H-imidazol-1-yl group, or an aminocarbonyl group protected by a tert-butoxycarbonyl group.
9 . A reagent for producing a labeling precursor compound, comprising the compound according to claim 1 .
10 . A labeling precursor reagent for a radioactive halogen-labeled compound, comprising the compound according to claim 4 .