Imidazole-pyrazole derivatives

1 . A compound of formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is selected from the group consisting of C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, and

 and R 2 is hydrogen or C 1 -C 6 -alkyl;

R 3 is selected from hydrogen, halogen, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;

R 4 and R 6 are each independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, cyano, halo-C 1 -C 6 -alkyl and halo-C 6 -alkoxy;

R 5a , R 5b and R 5c are each independently selected from the group consisting of hydrogen, halogen, hydroxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, amino-C 1 -C 6 -alkoxy, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy-, amino, C 1 -C 6 -alkyl-NH—, (C 1 -C 6 -alkyl) 2 N—, C 1 -C 6 -alkyl-NH—C(O)—, amino-C 1 -C 6 -alkyl-NH—, C 1 -C6-alkoxy-C 1 -C 6 -alkyl-NH—, carbamoyl-C 1 -C 6 -alkyl-NH—, (3- to 14-membered heterocyclyl)-C(O)—NH—, carbamoyl, and nitro;

R 7 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl and halo-C 1 -C 6 -alkyl;

R 8a is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, carbamoyl-C 1 -C 6 -alkyl, and;

R 8b is selected from the group consisting of hydrogen, hydroxy, oxo, hydroxy-C 1 -C 6 -alkyl, and

R 8c is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino, C 1 -C 6 -alkyl-NH—, and C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl;

R 8d is hydrogen or C 1 -C 6 -alkyl;

R 9a , R 9b , R 10a , R 10b , R 12a and R 12b are each independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, amino, nitro and hydroxy;

R 11a and R 11b are each independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkoxy, amino, nitro, hydroxy and

Y is carbonyl and X is selected from the group consisting of a covalent bond, NH, N(C 1 -C 6 -alkyl), NH—C 1 -C 6 -alkyldiyl, and C 1 -C 6 -alkyldiyl; or

X is carbonyl and Y is selected from the group consisting of a covalent bond, NH, N(C 1 -C 6 -alkyl), NH—C 1 -C 6 -alkyldiyl, and C 1 -C 6 -alkyldiyl;

X is C 1 -C 6 -alkyldiyl and Y is a covalent bond;

L 1 and L 3 are each independently selected from the group consisting of a covalent bond, —C(O)—NH—C 1 -C 6 -alkyldiyl-, —C 1 -C 6 -alkyldiyl-NH—C(O)—, —C(O)—NH—C 1 -C 6 -alkoxy-C 1 -C 6 -alkyldiyl-, —C 1 -C 6 -alkoxy-C 1 -C 6 -alkyldiyl-NH—C(O)—, carbonyl and C 1 -C 6 -alkyldiyl;

L 2 and L 4 are each independently selected from the group consisting of a covalent bond, carbonyl, —O—, —NH—C(O)—, —C(O)—NH—, —C(O)—NH—C 1 -C 6 -alkyldiyl-, —C 1 -C 6 -alkyldiyl-NH—C(O)—, and C 1 -C 6 -alkyldiyl;

A is 5- to 14-membered heteroaryl;

B, C, D, E and G are each independently 3- to 14-membered heterocyclyl and 5- to 14-membered heteroaryl; and

F is 3- to 14-membered heterocyclyl or C 3 -C 10 -cycloalkyl.

2 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is a compound of formula (I-I):

wherein:

R 13 is

 and

A, C, R 3 , R 4 , R 5a , R 5b , R 5c , R 6 , R 7 , R 8a and R 8b are as defined in claim 1 .

3 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is a compound of formula (I-II):

wherein:

 and

A, C, R 3 , R 5a , R 5b , R 5c , R 8a and R 8b are as defined in claim 1 .

4 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is selected from the group consisting of C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, and

 and R 2 is hydrogen or C 1 -C 6 -alkyl;

R 9a is hydrogen or hydroxy;

R 9b , R 10b , and R 12b are each hydrogen;

R 8a is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, carbamoyl-C 1 -C 6 -alkyl and

R 8b is selected from the group consisting of hydrogen, hydroxy, oxo, hydroxy-C 1 -C 6 -alkyl, and

R 8c is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino, C 1 -C 6 -alkyl-NH—, and C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl;

R 8d is hydrogen or C 1 -C 6 -alkyl;

R 10a is amino or nitro;

R 11a is selected from the group consisting of hydrogen, amino-C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, amino, hydroxy and

R 11b is selected from the group consisting of hydrogen, halo-C 1 -C 6 -alkyl, and hydroxy-C 1 -C 6 -alkyl;

R 12a is hydrogen or hydroxy;

X is carbonyl and Y is a covalent bond or C 1 -C 6 -alkyldiyl; or

X is selected from the group consisting of NH, N(C 1 -C 6 -alkyl), and NH—C 1 -C 6 -alkyldiyl;

and Y is carbonyl; or

X is C 1 -C 6 -alkyldiyl and Y is a covalent bond;

L 1 is C 1 -C 6 -alkyldiyl;

L 2 is —O—;

L 3 is selected from the group consisting of a covalent bond, C(O)—NH—C 1 -C 6 -alkyldiyl-, —C(O)—NH—C 1 -C 6 -alkoxy-C 1 -C 6 -alkyldiyl-, and C 1 -C 6 -alkyldiyl;

L 4 is selected from the group consisting of carbonyl, —C(O)—NH—, and —C(O)—NH—C 1 -C 6 -alkyldiyl-;

B, C, D and G are each independently 3- to 14-membered heterocyclyl;

E is 5- to 14-membered heteroaryl; and

F is 3- to 14-membered heterocyclyl.

5 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is

 and R 2 is C 1 -C 6 -alkyl;

R 8a is hydrogen or C 1 -C 6 -alkyl;

R 8b is hydrogen or hydroxy;

R 8c is hydrogen or C 1 -C 6 -alkyl-NH—;

R 8d is hydrogen;

R 11a is

R 11b is hydrogen;

R 12a is hydroxy;

R 12b is hydrogen;

X is carbonyl;

Y is a covalent bond or C 1 -C 6 -alkyldiyl;

L 3 is a covalent bond;

L 4 is carbonyl; and

B, C, F and G are each independently 3- to 14-membered heterocyclyl.

6 . The compound of claim 5 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is

 and R 2 is methyl;

R 8a is hydrogen or methyl;

R 8b is hydrogen or hydroxy;

R 8c is hydrogen or methyl-NH—;

R 8d is hydrogen;

R 11a is

R 11b is hydrogen

R 12a is hydroxy;

R 12b is hydrogen;

X is carbonyl;

Y is a covalent bond or —CH 2 —;

L 3 is a covalent bond;

L 4 is carbonyl;

B is selected from the group consisting of piperazinyl, piperidyl, and 2,8-diazaspiro[4.5]decan-8-yl;

C is piperidyl or pyrrolidinyl;

F is piperidyl; and

G is pyrrolidinyl.

7 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is halogen or C 1 -C 6 -alkyl.

8 . The compound of formula (I) according to claim 7 , or a pharmaceutically acceptable salt thereof, wherein R 3 is halogen.

9 . The compound of formula (I) claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

R 4 is selected from the group consisting of C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, cyano and halo-C 1 -C 6 -alkyl; and

R 6 is hydrogen or halo-C 1 -C 6 -alkyl.

10 . The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein:

R 4 is halo-C 1 -C 6 -alkyl; and

R 6 is hydrogen.

11 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

A is 5- to 14-membered heteroaryl;

R 5a is selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, amino-C 1 -C 6 -alkoxy, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy-, amino, C 1 -C 6 -alkyl-NH—, (C 1 -C 6 -alkyl) 2 N—, C 1 -C 6 -alkyl-NH—C(O)—, amino-C 1 -C 6 -alkyl-NH—, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-NH—, carbamoyl-C 1 -C 6 -alkyl-NH—, (3- to 14-membered heterocyclyl)-C(O)—NH—, carbamoyl and nitro;

R 5b is selected from the group consisting of hydrogen, halogen, and amino; and

R 5c is hydrogen.

12 . The compound of claim 11 , or a pharmaceutically acceptable salt thereof, wherein:

A is 5- to 14-membered heteroaryl;

R 5a is selected from the group consisting of halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, hydroxy-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-NH—, amino-C 1 -C 6 -alkyl-NH—, and amino;

R 5b is hydrogen or amino; and

R 5c is hydrogen.

13 . The compound of claim 12 , or a pharmaceutically acceptable salt thereof, wherein:

A is pyridyl;

R 5a is selected from the group consisting of fluoro, methyl, methoxy, hydroxymethyl, methylamino, 2-aminoethyl-NH—, and amino;

R 5b is hydrogen or amino; and

R 5c is hydrogen.

14 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is C 1 -C 6 -alkyl.

15 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is selected from the group consisting of C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, and

 and R 2 is hydrogen or C 1 -C 6 -alkyl;

R 3 is halogen or C 1 -C 6 -alkyl;

R 4 is selected from the group consisting of C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, cyano and halo-C 1 -C 6 -alkyl;

R 5a is selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, amino-C 1 -C 6 -alkoxy, hydroxy-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-, C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy-, amino, C 1 -C 6 -alkyl-NH—, (C 1 -C 6 -alkyl) 2 N—, C 1 -C 6 -alkyl-NH—C(O)—, amino-C 1 -C 6 -alkyl-NH—, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl-NH—, carbamoyl-C 1 -C 6 -alkyl-NH—, (3- to 14-membered heterocyclyl)-C(O)—NH—, carbamoyl and nitro;

R 5b is selected from the group consisting of hydrogen, halogen, and amino;

R 5c is hydrogen;

R 6 is hydrogen or halo-C 1 -C 6 -alkyl;

R 7 is C 1 -C 6 -alkyl;

R 8a is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, carbamoyl-C 1 -C 6 -alkyl and

R 8b is selected from the group consisting of hydrogen, hydroxy, oxo, hydroxy-C 1 -C 6 -alkyl, and

R 8c is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, amino, C 1 -C 6 -alkyl-NH—, and C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl;

R 8d is hydrogen or C 1 -C 6 -alkyl;

R 9a is hydrogen or hydroxy;

R 9b , R 10b , and R 12b are each hydrogen;

R 10a is amino or nitro;

R 11a is selected from the group consisting of hydrogen, amino-C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, amino, hydroxy and

R 11b is selected from the group consisting of hydrogen, halo-C 1 -C 6 -alkyl, and hydroxy-C 1 -C 6 -alkyl;

R 12a is hydrogen or hydroxy;

X is carbonyl and Y is a covalent bond or C 1 -C 6 -alkyldiyl; or

X is selected from the group consisting of NH, N(C 1 -C 6 -alkyl), and NH—C 1 -C 6 -alkyldiyl;

and Y is carbonyl; or

X is C 1 -C 6 -alkyldiyl and Y is a covalent bond;

L 1 is C 1 -C 6 -alkyldiyl;

L 2 is —O—;

L 3 is selected from the group consisting of a covalent bond, C(O)—NH—C 1 -C 6 -alkyldiyl-, —C(O)—NH—C 1 -C 6 -alkoxy-C 1 -C 6 -alkyldiyl-, and C 1 -C 6 -alkyldiyl;

L 4 is selected from the group consisting of carbonyl, —C(O)—NH—, and —C(O)—NH—C 1 -C 6 -alkyldiyl-;

A is 5- to 14-membered heteroaryl;

B, C, D and G are each independently 3- to 14-membered heterocyclyl;

E is 5- to 14-membered heteroaryl; and

F is selected from the group consisting of 5- to 14-membered heteroaryl, C3-C10-cycloalkyl, and 3- to 14-membered heterocyclyl.

16 . The compound of claim 15 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is

 and R 2 is C 1 -C 6 -alkyl;

R 3 is halogen;

R 4 is halo-C 1 -C 6 -alkyl;

R 5a is selected from the group consisting of halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, hydroxy-C 1 -C 6 -alkyl, amino-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-NH—, amino-C 1 -C 6 -alkyl-NH—, and amino;

R 5b is hydrogen or amino;

R 5c and R 6 are hydrogen;

R 7 is C 1 -C 6 -alkyl;

R 8a is hydrogen or C 1 -C 6 -alkyl;

R 5b is hydrogen or hydroxy;

R 8c is hydrogen or C 1 -C 6 -alkyl-NH—;

R 8d is hydrogen;

R 11a is

R 11b is hydrogen;

R 12a is hydroxy;

R 12b is hydrogen;

X is carbonyl;

Y is a covalent bond or C 1 -C 6 -alkyldiyl;

L 3 is a covalent bond;

L 4 is carbonyl;

A is 5- to 14-membered heteroaryl;

B, C, F and G are each independently 3- to 14-membered heterocyclyl.

17 . The compound of claim 16 , or a pharmaceutically acceptable salt thereof, wherein:

R 1 and R 2 , taken together with the nitrogen atom to which they are attached, form a group of formula (II), (III) or (IV):

or

R 1 is

 and R 2 is methyl;

R 3 is chloro;

R 4 is CF 3 ;

R 5a is selected from the group consisting of fluoro, methyl, methoxy, hydroxymethyl, methylamino, 2-aminoethyl-NH—, and amino;

R 5b is hydrogen or amino;

R 5c and R 6 are hydrogen;

R 7 is methyl;

R 8a is hydrogen or methyl;

R 8b is hydrogen or hydroxy;

R 8c is hydrogen or methyl-NH—;

R 8d is hydrogen;

R 11a is

R 11b is hydrogen

R 12a is hydroxy;

R 12b is hydrogen;

X is carbonyl;

Y is a covalent bond or —CH 2 —;

L 3 is a covalent bond;

L 4 is carbonyl;

A is pyridyl;

B is selected from the group consisting of piperazinyl, piperidyl, and 2,8-diazaspiro[4.5]decan-8-yl;

C is piperidyl or pyrrolidinyl;

F is piperidyl; and

G is pyrrolidinyl.

18 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

N-[3-Chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-pyrimidin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(4-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(5-chloro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(5-methoxypyrimidin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-aminopyrimidin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[5-(2-methoxyethoxy)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[5-(2-methoxyethoxy)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(5-fluoropyrimidin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(1h-pyrazolo[3,4-d]pyrimidin-6-yl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[3-(trifluoromethyl)-1-[3-(trifluoromethyl)-2-pyridyl]pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(4-methoxy-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(5-methoxy-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-[4-(2-aminoethoxy)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(4-aminopyrimidin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[4-(methylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[4-(dimethylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[4-(dimethylamino)pyrimidin-2-yl]-5-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[4-(2-methoxyethylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-pyrazin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-Chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[5-(dimethylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-[5-(2-aminoethylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[6-(dimethylamino)pyridazin-3-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-Amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[5-(2-methoxyethylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-[5-[(3-amino-3-oxo-propyl)amino]-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(4-methoxypyrimidin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(2-methoxypyrimidin-4-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[1-(piperidine-4-carbonyl)-4-piperidyl]methylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[(3S)-morpholine-3-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(difluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-methoxy-pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-cyano-pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-methyl-pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-ethyl-pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-aminopyridazin-3-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(4-methyl-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[2-(3-hydroxypyrrolidin-1-yl)acetyl]piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-[(2S,3S)-3-hydroxypyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(5-nitro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

5-[1-[5-(2-aminoethylamino)pyrimidin-2-yl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(4-hydroxypiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-[(2S,3S)-3-hydroxypyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-[2-(3-hydroxypyrrolidin-1-yl)acetyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-methyl-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-[(2S,4R)-4-hydroxypyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-[5-(methylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[1-(2-methoxyethyl)pyrazol-4-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[1-(2-methoxyethyl)-5-methyl-pyrazol-4-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[1-(2-methoxyethyl)imidazol-4-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(1-methylimidazol-4-yl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(5-methyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(5-methyl-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(4-methyl-1H-pyrazol-5-yl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[4-[4-[(1R,5S)-3-Azabicyclo[3.1.0]hexane-6-carbonyl]piperazine-1-carbonyl]-3-chloro-phenyl]-1-methyl-5-[1-pyrimidin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[[(1R,5S)-3-[(2S,4R)-4-hydroxypyrrolidine-2-carbonyl]-3-azabicyclo[3.1.0]hexan-6-yl]carbamoyl]phenyl]-1-methyl-5-[1-pyrimidin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[[(1S,5R)-3-(piperidine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl]carbamoyl]phenyl]-1-methyl-5-[1-pyrimidin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-[(3S,4R)-3-hydroxypiperidine-4-carbonyl]piperazine-1-carbonyl]phenyl]-5-[1-(5-methoxy-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[4-[1-(Azetidin-3-ylmethyl)piperidine-4-carbonyl]piperazine-1-carbonyl]-3-chloro-phenyl]-1-methyl-5-[1-pyrimidin-2-yl-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

5-[1-(5-Amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperazine-1-carbonyl)piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[3-(hydroxymethyl)piperazine-1-carbonyl]piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-Amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[(2-oxopiperazin-1-yl)methyl]piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(1H-pyrazol-3-ylmethylcarbamoyl)phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-Chloro-4-[4-[(2S)-4-hydroxypiperidine-2-carbonyl]piperazine-1-carbonyl]phenyl]-1-methyl-5-[1-(5-nitro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[5-(ethylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[(3R)-3-(aminomethyl)pyrrolidine-1-carbonyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-(3-aminopropylcarbamoyl)-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4-piperidylmethylcarbamoyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4-piperidylmethylcarbamoyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(methylamino)piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3-methylolpyrrolidin-3-yl)carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[4-[[1-(aminomethyl)cyclopropyl]carbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[(3S)-3-(aminomethyl)pyrrolidine-1-carbonyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(2,8-diazaspiro[4.5]decane-8-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(1-methylpiperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-[4-(methoxymethyl)-1H-pyrazol-3-yl]-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

N-[4-[cis-(3-aminocyclobutyl)carbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[methyl(4-piperidyl)carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[4-[4-(aminomethyl)piperidine-1-carbonyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[[3-(aminomethyl)-3-(chloromethyl)cyclobutyl]carbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[[(trans-3-aminocyclopentyl]carbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-(2-aminoethylcarbamoyl)-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[(2-aminocyclopropyl)methylcarbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[trans-(3-aminocyclobutyl)carbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-(4-aminopiperidine-1-carbonyl)-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[4-[2-(2-aminoethoxy)ethylcarbamoyl]-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[2-[(2S,4R)-4-hydroxyprolyl]-2,8-diazaspiro[4.5]decane-8-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[(1R,3R)-3-[[(2S,4R)-4-hydroxyprolyl]amino]cyclopentyl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[[(2S,4R)-4-hydroxyprolyl]amino]piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[6-[[(2S,4R)-4-hydroxyprolyl]amino]-2-azaspiro[3.3]heptane-2-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[3-[[(2S,4R)-4-hydroxyprolyl]amino]propylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-aminopyridin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[4-(hydroxymethyl)-1-[rac-(2R,4S)-4-hydroxypyrrolidine-2-carbonyl]pyrrolidin-3-yl]carbamoyl]phenyl]-1-methylimidazole-2-carboxamide;

N-[4-(5-aminopentylcarbamoyl)-3-chloro-phenyl]-5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-aminopyrazin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-[(2S,4R)-4-hydroxyprolyl]piperazine-1-carbonyl]phenyl]-5-[1-(6-chloro-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-5-[1-(6-methoxy-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(piperazine-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[2-[[(2S,4R)-4-hydroxyprolyl]amino]ethylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[1-[(2S,4R)-4-hydroxyprolyl]-4-piperidyl]methylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[1-[(2S,4R)-4-hydroxyprolyl]-4-piperidyl]-methyl-carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[2-[[(2S,4R)-4-hydroxyprolyl]amino]cyclopropyl]methylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[5-[(2S,4R)-4-hydroxyprolyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-2-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[trans-[3-[[(2S,4R)-4-hydroxyprolyl]amino]cyclobutyl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3S)-3-[[[(2S,4R)-4-hydroxyprolyl]amino]methyl]pyrrolidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[2-[2-[[(2S,4R)-4-hydroxyprolyl]amino]ethoxy]ethylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[(7S)-2-[(2S,4R)-4-hydroxyprolyl]-5-oxa-2-azaspiro[3.4]octan-7-yl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[cis-[3-[[(2S,4R)-4-hydroxyprolyl]amino]cyclobutyl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[1-[[(2S,4R)-4-hydroxyprolyl]amino]cyclopropyl]methylcarbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3R)-3-[[[(2S,4R)-4-hydroxyprolyl]amino]methyl]pyrrolidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[[[(2S,4R)-4-hydroxyprolyl]amino]methyl]piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-[[(2S,4R)-4-hydroxyprolyl]-methyl-amino]piperidine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[3-[[(2S,4R)-4-hydroxyprolyl]amino]-1-bicyclo[1.1.1]pentanyl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[[(1S,3S)-3-[[(2S,4R)-4-hydroxyprolyl]amino]cyclopentyl]carbamoyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-5-[1-(6-methoxypyrimidin-4-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(2-chloropyridin-4-yl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methylimidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4,7-diazaspiro[2.5]octane-7-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3R)-3-methyl-1,4-diazepane-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(3,9-diazabicyclo[3.3.1]nonane-3-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(2S,6R)-2,6-dimethylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(2S)-2-methylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(3,3-dimethylpiperazine-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3S)-3-isopropylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(3,6-diazabicyclo[3.2.0]heptane-3-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(1,4-diazepane-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(3S)-3-methylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(3,8-diazabicyclo[3.2.1]octane-8-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(2R)-2-ethylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(2S)-2-ethylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(2-piperazinoethylcarbamoyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4,7-diazaspiro[2.5]octane-4-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(2S,3R)-2,3-dimethylpiperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[3-(methoxymethyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[(1R,5R)-3,6-diazabicyclo[3.2.0]heptane-3-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-3-fluoro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-6-fluoro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-5-[1-(2-methoxy-4-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-5-fluoro-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-5-[1-(6-methoxy-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(diethylcarbamoyl)phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-5-methyl-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-4-methyl-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-2-methyl-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-4-chloro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-4-chloro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide”;

5-[1-(5-amino-3-methyl-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-4-methyl-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-2-fluoro-4-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(6-amino-2-fluoro-3-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(4-amino-5-nitro-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methyl-imidazole-2-carboxamide;

5-[1-(5-amino-6-methylpyridin-2-yl)-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-1-methylimidazole-2-carboxamide;

N-[3-chloro-4-[4-(piperidine-4-carbonyl)piperazine-1-carbonyl]phenyl]-5-[1-(4,5-diamino-2-pyridyl)-3-(trifluoromethyl)pyrazol-4-yl]-1-methyl-imidazole-2-carboxamide;

N-[6-[4-[2-[[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]carbamoyl]-3-methyl-imidazol-4-yl]-3-(trifluoromethyl)pyrazol-1-yl]-3-pyridyl]isonipecotamide; and

5-[1-[5-(2-aminoethylamino)-2-pyridyl]-3-(trifluoromethyl)pyrazol-4-yl]-N-[3-chloro-4-(4-isonipecotoylpiperazine-1-carbonyl)phenyl]-1-methyl-imidazole-2-carboxamide.

19 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.

20 . A method for the treatment or prevention of infections and resulting diseases caused by Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species or E. coli , or a combination thereof, the method comprising administering a compound of claim 1 , or a pharmaceutically acceptable salt thereof, to a mammal in need thereof.