IP Library › Granted Patent US 12679855
Granted Patent B2
US 12679855 · App. 17/425,472 · Granted Jul 14, 2026

Inhibitors of the enzyme enolase for precision oncology

Inventors: Florian Muller (Houston, TX); Victoria Yan (Houston, TX); Kristine Yang (Houston, TX); Elliot Ballato (Houston, TX); Cong-dat Pham (Houston, TX)
Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
C07F9/6506C07F9/59C07F9/65515C07F9/655345C07F9/657181
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Quick Facts
Patent No.
US 12679855
App. No.
17/425,472
Granted
Jul 14, 2026
Kind
B2
Abstract

Provided herein are compounds of the formula: wherein the variables are defined herein. The present disclosure also provides pharmaceutical compositions comprising the compounds disclosed herein as well as methods of treatment using the compounds and/or compositions disclosed herein. Such compounds and compositions may be used, for example, for the inhibition of enolase enzymes.

Claims (6)

1 . A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2 . A pharmaceutical composition comprising:

(a) a compound of claim 1 ; and

(b) an excipient.

3 . A method of treating cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound or composition of claim 1 .