Peptide, and cell fusion agent and pharmaceutical composition for cancer therapy containing said peptide
View Patent ↗An object of the present invention is to provide an efficient method of cell fusion, and to provide a method of killing cancer cells by cell fusion. The object can be solved by (1) a polypeptide comprising an amino acid sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs: 1 to 8, or (2) a polypeptide comprising an amino acid sequence, in which 1 to 4 amino acids are deleted, substituted, inserted, and/or added in an amino acid sequence of SEQ ID NOs: 1 to 8, and having a cell fusion activity.
1 . A polypeptide comprising an amino acid sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs: 1 to 8, wherein the N-terminus of SEQ ID NO:2 is methylated.
2 . The polypeptide according to claim 1 , wherein the polypeptide comprises an amino acid sequence selected from SEQ ID Nos: 1 and 3-8, and the N-terminus of the polypeptide is methylated.
3 . A polynucleotide encoding the polypeptide according to claim 1 .
4 . A vector comprising the polynucleotide according to claim 3 .
5 . A transformant comprising the vector according to claim 4 .
6 . A cell fusion agent comprising the polypeptide according to claim 1 , as an active ingredient.
7 . A pharmaceutical composition comprising the polypeptide according to claim 1 , as an active ingredient.
8 . A method for treating Lung cancer, comprising a step of administrating to a subject in need of such treatment a therapeutically effective amount of the polypeptide according to claim 1 .