IP Library › Granted Patent US 12679876
Granted Patent B2
US 12679876 · App. 17/294,497 · Granted Jul 14, 2026

Activin/BMP7 chimeras: super-active SAB704 and SAB715, and their respective nogginsensitized variants, NAB704 and NAB715; and NAB204

Inventors: Seunghyon Choe (Incheon, KR); So-Mi Yoon (Incheon, KR)
Assignee: OSR Holdings Co., Ltd.
C07K14/495C07K14/51A61K38/00
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Quick Facts
Patent No.
US 12679876
App. No.
17/294,497
Granted
Jul 14, 2026
Kind
B2
Abstract

The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides with improved or novel biological and therapeutic properties.

Claims (5)

1 . A recombinant polypeptide comprising an amino acid selected from the group consisting of SEQ ID NO: 8, SEQ ID NO: 10 and SEQ ID NO: 12, wherein the recombinant polypeptide modulates the SMAD pathway.

2 . A polynucleotide encoding the recombinant polypeptide of claim 1 .

3 . A vector comprising the polynucleotide of claim 2 .

4 . A host cell genetically encoding or comprising the vector of claim 3 .

5 . A pharmaceutical composition comprising the recombinant polypeptide of claim 1 .