IP Library › Granted Patent US 12679884
Granted Patent B2
US 12679884 · App. 17/997,582 · Granted Jul 14, 2026

Red light-controlled protein dimerization systems

Inventors: Liangcai Gu (Seattle, WA); Zhimin Huang (Seattle, WA); Xiao Zhang (Seattle, WA)
Assignee: UNIVERSITY OF WASHINGTON
C07K16/1267C07K2317/22C07K2317/569C07K2317/92C07K2317/94
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Quick Facts
Patent No.
US 12679884
App. No.
17/997,582
Granted
Jul 14, 2026
Kind
B2
Abstract

Deinococcus radiodurans phytochrome (DrBphP) light form-binding antibodies are disclosed and their use in light-induced dimerization systems.

Claims (20)

1 . A Deinococcus radiodurans bacteriophytochrome (DrBphP) light form-binding single chain antibody, comprising a set of complementarity-determining regions (CDRs) selected from the group consisting of:

(a) SEQ ID NO:1 (CDR1), SEQ ID NO:2 (CDR2), and SEQ ID NO:3 (CDR3); or

(b) SEQ ID NO:4 (CDR1), SEQ ID NO:5 (CDR2), and SEQ ID NO:6 (CDR3).

2 . The antibody of claim 1 , comprising an amino acid sequence at least 40% identical to the amino acid sequence of SEQ ID NO:9 or SEQ ID NO:10.

3 . A nucleic acid encoding the antibody of claim 2 .

4 . An expression vector comprising the nucleic acid of claim 3 , operatively linked to a control sequence.

5 . A solid support, comprising the antibody of claim 1 bound to the solid support.

6 . A nucleic acid encoding the antibody of claim 1 .

7 . An expression vector comprising the nucleic acid of claim 6 , operatively linked to a control sequence.

8 . A cell that comprises the expression vector of claim 7 .

9 . The antibody of claim 1 , comprising an amino acid sequence at least 60% identical to the amino acid sequence of SEQ ID NO:9 or SEQ ID NO:10.

10 . The antibody of claim 1 , comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:9 or SEQ ID NO: 10.

11 . A nucleic acid encoding the antibody of claim 10 .

12 . An expression vector comprising the nucleic acid of claim 11 , operatively linked to a control sequence.

13 . The antibody of claim 1 , comprising an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:9.

14 . The antibody of claim 1 , comprising an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:10.

15 . The antibody of claim 1 , comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:9.

16 . The antibody of claim 1 , comprising an amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:10.

17 . The antibody of claim 1 , comprising the amino acid sequence of SEQ ID NO:9.

18 . The antibody of claim 1 , comprising the amino acid sequence of SEQ ID NO:10.