Poly[alpha-cyanoacrylate] hydrolyzate and preparation method and application thereof
View Patent ↗The invention relates to a poly[α-cyanoacrylate] hydrolyzate, a preparation method and an application thereof, belonging to the field of pharmaceutical and chemical industry. A main technical solution is as follows: provided is a poly[α-cyanoacrylate] hydrolyzate having a chemical formula: CH 2 —CRCOOH n , wherein R=—CN or —COOH. Poly[2-cyanoacrylic acid] provided by the present invention is dispersed in water to prepare the negatively charged microsphere, that is, to obtain the new blank embolic microsphere, the particle size of the microsphere can be adjusted in a micron-scale range, and the microsphere have a deformation function to pass through a vascular with a specific shape, which can tightly embolize the vascular to avoid ectopic embolism caused by falling off; poly[2-carboxyacrylic acid] can be used for preparing a new nano-drug carrier, improving the curative effect of the carried drug on diseased tissues and reduce the toxic and side effects of the carried drug on normal tissues.
1 . A method comprising the steps of:
preparing an alkyl α-cyanoacrylate polymer;
forming a dispersion of the alkyl α-cyanoacrylate polymer in anhydrous ethanol;
adding an aqueous base to the dispersion to hydrolyze the alkyl α-cyanoacrylate polymer under alkaline conditions to obtain a hydrolysate solution, wherein:
all ester bonds of the alkyl α-cyanoacrylate polymer are hydrolyzed selectively under alkaline conditions and cyano groups are retained, and the hydrolysate solution includes poly[2-cyanoacrylic acid] dissolved in water, or
all ester bonds and cyano groups of the alkyl α-cyanoacrylate polymer are hydrolyzed, and the hydrolysate solution includes poly[2-carboxyacrylic acid] dissolved in water; and
for the hydrolysate solution that includes poly[2-cyanoacrylic acid]:
separating the poly[2-cyanoacrylic acid] from the hydrolysate solution and preparing a blank embolic microsphere using the poly[2-cyanoacrylic acid];
for the hydrolysate solution that includes poly[2-carboxyacrylic acid]:
separating the poly[2-carboxyacrylic acid] from the hydrolysate solution and preparing a nano-drug carrier using the poly[2-carboxyacrylic acid].