Patent
The present disclosure relates to a Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity and a method of producing L-lysine using the same. The Corynebacterium glutamicum mutant strain may produce L-lysine in an improved yield by inhibiting the conversion of oxaloacetate to citrate due to decreased or inhibited expression of the gene encoding the citrate synthase.
1 . A Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity due to weakened activity of citrate synthase compared to an unmodified Corynebacterium glutamicum,
wherein the weakened activity of the citrate synthase is achieved by replacement of a start codon of a gene encoding the citrate synthase comprising the nucleotide sequence of SEQ ID NO: 1 with TTG.