Capture vessel cartridge for permeation testing of prefilled packages and containers

1 . A cartridge for use in conjunction with a target analyte permeation testing instrument for measuring transmission rate of a target analyte through a prefilled package or container, wherein the target analyte permeation testing instrument includes a line carrying a target analyte free carrier gas from a source of the carrier gas to a target analyte sensor, characterized in that the cartridge comprises:

(a) a metal cylindrical vessel defining a void volume and having open axial ends with a ferrule at each axial end of the cylinder,

(b) a first metal end cap capable of repeated sealed engagement over one of the open axial ends of the vessel when in a closed position, and unsealed disengagement from over the one open axial end of the vessel for providing access to the void volume of the vessel when in an open position,

(c) a second metal end cap in sealed engagement over the other open axial end of the vessel,

(d) an entrance port configured and arranged for connection with the line for providing fluid communication from the source of carrier gas to the void volume of the vessel, and

(e) an exit port for connection with the line for providing fluid communication from the void volume of the vessel to the target analyte sensor, and

(f) a first sanitary clamp operable for releasably axially compressing the first end cap onto to the cylinder.

2 . The cartridge of claim 1 wherein the cartridge further comprises a second sanitary clamp operable for releasably axially compressing the second end cap onto the cylinder.

3 . A method for measuring transmission rate of a target analyte through a sealed container filled with a product containing target analyte using a cartridge in accordance with claim 2 , comprising the steps of:

(a) placing the sealed container into the void volume of the vessel through one axial end of the vessel to form a headspace within the vessel,

(b) closing and sealing the first end cap onto the vessel over the one axial end of the vessel,

(c) flushing target analyte from the headspace with target analyte free carrier gas from the source of target analyte free carrier gas using the line attached to the entrance and exit ports on the cartridge to form a flushed headspace,

(d) sensing and obtaining a measured value of target analyte carried by the target analyte free carrier gas flowing from the flushed headspace through the line to the sensor, and

(e) calculating transmission rate of target analyte through the sealed container using the measured value of target analyte sensed by the sensor.

4 . The cartridge of claim 1 wherein the first end cap is capable of repeated gasket sealed engagement over one of the open axial ends of the vessel, and the second end cap is in gasket sealed engagement over the other open axial end of the vessel.

5 . A method for measuring transmission rate of a target analyte through a sealed container filled with a product containing target analyte using a cartridge in accordance with claim 4 , comprising the steps of:

(a) placing the sealed container into the void volume of the vessel through one axial end of the vessel to form a headspace within the vessel,

(b) closing and sealing the first end cap onto the vessel over the one axial end of the vessel,

(c) flushing target analyte from the headspace with target analyte free carrier gas from the source of target analyte free carrier gas using the line attached to the entrance and exit ports on the cartridge to form a flushed headspace,

(d) sensing and obtaining a measured value of target analyte carried by the target analyte free carrier gas flowing from the flushed headspace through the line to the sensor, and

(e) calculating transmission rate of target analyte through the sealed container using the measured value of target analyte sensed by the sensor.

6 . The cartridge of claim 1 wherein the cylinder defines a void volume of between 20 in 3 and 600 in 3 .

7 . A method for measuring transmission rate of a target analyte through a sealed container filled with a product containing target analyte using a cartridge in accordance with claim 6 , comprising the steps of:

(a) placing the sealed container into the void volume of the vessel through one axial end of the vessel to form a headspace within the vessel,

(b) closing and sealing the first end cap onto the vessel over the one axial end of the vessel,

(c) flushing target analyte from the headspace with target analyte free carrier gas from the source of target analyte free carrier gas using the line attached to the entrance and exit ports on the cartridge to form a flushed headspace,

(d) sensing and obtaining a measured value of target analyte carried by the target analyte free carrier gas flowing from the flushed headspace through the line to the sensor, and

(e) calculating transmission rate of target analyte through the sealed container using the measured value of target analyte sensed by the sensor.

8 . A kit for target analyte permeation testing of prefilled packages or containers comprising at least three cartridges in accordance with claim 1 , each having different void volumes that differ by at least 100 in 3 .

9 . A method for measuring transmission rate of a target analyte through a sealed container filled with a product containing target analyte using a cartridge in accordance with claim 1 , comprising the steps of:

(a) placing the sealed container into the void volume of the vessel through one axial end of the vessel to form a headspace within the vessel,

(b) closing and sealing the first end cap onto the vessel over the one axial end of the vessel,

(c) flushing target analyte from the headspace with target analyte free carrier gas from the source of target analyte free carrier gas using the line attached to the entrance and exit ports on the cartridge to form a flushed headspace,

(d) sensing and obtaining a measured value of target analyte carried by the target analyte free carrier gas flowing from the flushed headspace through the line to the sensor, and

(e) calculating transmission rate of target analyte through the sealed container using the measured value of target analyte sensed by the sensor.