IP Library Granted Patent US 12,681,033
Granted Patent B2
US 12,681,033 · App. 18/075,753 · Granted Jul 14, 2026

Reagent reservoirs and related systems and methods

Inventors: Paul Crivelli (San Diego, CA); Justin Davidson (Solana Beach, CA); Norman Khoo (San Diego, CA)
Assignee: ILLUMINA, INC.
G01N35/1002G01N2035/00287G01N2035/00306G01N2035/1055
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Quick Facts
Patent No.
US 12,681,033
App. No.
18/075,753
Granted
Jul 14, 2026
Kind
B2
Abstract

Reagent reservoirs and related systems and methods are disclosed. In accordance with a first implementation, an apparatus includes a system and a reagent reservoir. The system includes a reagent reservoir receptacle. The reagent reservoir is received within the reagent reservoir receptacle and has a body and a fluidic port. The body defines a storage chamber, a sipper chamber, and a fluidic sinus fluidly coupling the storage chamber and the sipper chamber. The fluidic port is fluidly coupled to the sipper chamber.

Claims (21)

1 . An apparatus comprising:

a system, comprising:

a pneumatic interface; and

a receptacle;

a liquid reservoir receivable within the receptacle and having:

a body comprising a top surface comprising a fluidic opening, a storage chamber having an opening at the top surface, a fluidic sinus, and a side of the body defining an outward-facing groove, the fluidic opening fluidly coupled to the groove, and the fluidic sinus fluidly coupling the storage chamber and the groove,

a cover secured to the side of the body, the groove and the cover defining a sipper fluidic path, the fluidic sinus is positioned adjacent a bottom surface of the storage chamber, the fluidic sinus fluidly couples the storage chamber and the sipper fluidic path;

a lid assembly coupled to the top surface and having a first portion covering the opening of the storage chamber and a second portion covering the fluidic opening, the top surface and the first portion defining a plenum,

the first portion comprising a pneumatic port fluidly coupled to the plenum; and

the second portion comprising a fluidic port fluidly coupled to the fluidic opening, the sipper fluidic path extending from the fluidic sinus, along the side, and toward the fluidic opening; and

a cartridge assembly, comprising:

a fluidic interface removably couplable to the fluidic port;

a well; and

a channel fluidly coupled between the fluidic interface and the well.

2 . The apparatus of claim 1 , further comprising liquid contained within the storage chamber.

3 . The apparatus of claim 1 , further comprising dried reagent contained within the well.

4 . The apparatus of claim 1 , wherein the cartridge assembly comprises a flow cell.

5 . The apparatus of claim 1 , wherein the cover comprises a laminate.

6 . The apparatus of claim 1 , further comprising a horizontal channel within the body between the groove and the fluidic opening.

7 . The apparatus of claim 6 , further comprising a stuffer disposed within the horizontal channel.

8 . The apparatus of claim 7 , wherein the stuffer defines a horizontal channel fluidly coupling the storage chamber and the fluidic port.