Method of detecting one or more change in an eye and disease indication or diagnosis
A method of detecting one or mor change in an eye and method diagnosing or proving an indication of an eye disease or eye condition or a neurogenerative disease or condition, or a predisposition thereto are disclosed. The method of detection comprises comparing an image of the eye with at least one asynchronous image of the eye to thereby detect the one or more change in the eye wherein the change comprises a darkening or lightening in pigment of the Retinal Pigment Epithelium (RPE) in the macula. The method of diagnosing or providing an indication of an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto comprises the same comparison and when the change is detected, providing a diagnosis of indication of or predisposition to an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto.
1 . A method of detecting one or more change in an eye, the method comprising:
comparing an image of the eye with at least one asynchronous image of the eye to thereby detect the one or more change in the eye wherein the change comprises a darkening or lightening in pigment of the Retinal Pigmented Epithelium (RPE) in the macula occurring in either direction from one point in time to another point in time in the form of one or both of a pigmentary disturbance and mottling.
2 . The method of claim 1 , wherein when the change is detected by providing a diagnosis of, indication of or predisposition to an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto.
3 . The computer program product of claim 2 , comprising:
computer readable program code devices (ii) configured, when a change is detected, to cause the computer by one or more computer processing element to provide a diagnosis of, indication of or prognosis of an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto.
4 . The method of claim 1 , wherein the change in pigment indicates neovascularization or a new blood vessel.
5 . The method, of claim 1 , wherein the change is an absence of drusen or any change in drusen.
6 . The method of claim 1 , wherein the comparing may comprise image registration.
7 . The method of claim 1 , wherein the image and the at least one asynchronous image are processed.
8 . The method of claim 1 , wherein the comparing comprises one or more of determining intensity levels; determining a distribution of gradient magnitude; determining intensity profile.
9 . The method of claim 1 , wherein the change is detected by comparing intensity levels.
10 . The method of claim 1 , further comprising monitoring a fellow eye of a subject with neovascularisation in the other retina with the method, computer program product, device or system.
11 . The method of claim 1 , wherein the change may be associated with a marker of MHC class II proteins.
12 . The method of claim 1 , wherein the eye disease or condition comprises dry AMD.
13 . The method of claim 1 , wherein the treatment comprises prophylactic treatment.
14 . The method of claim 1 , wherein the one or more eye disease or condition comprises glaucoma.
15 . The method of claim 1 , wherein the eye disease and/or condition is a diabetic eye disease and/or condition.
16 . The method of claim 1 , wherein when the one or more change is detected, one or more mineralocorticoid and/or one or more glucocorticoid or a therapeutically active analogue, derivative, homolog, pharmaceutically acceptable salt or conjugate thereof is applied to the eye.
17 . The method of claim 1 , wherein when the one or more change is detected, a treatment with hemp, hemp oil or a pharmaceutically effective extract is applied.
18 . The method of claim 1 , wherein the eye disease or condition comprises age related maculopathy or wet age related maculopathy.
19 . A computer program product comprising a non-transitory computer useable medium said computer program product comprising:
a computer usable medium and computer readable program code embodied on said computer usable medium for detecting one or more change in an eye, the computer readable code comprising:
computer readable program code devices (i) configured to cause the computer to compare by one or more computer processing element an image of the eye with at least one asynchronous image of the eye to thereby detect the one or more change in the eye wherein the change comprises a darkening or lightening in pigment of the Retinal Pigmented Epithelium (RPE) and/or macula occurring in either direction from one point in time to another point in time in the form of one or both of a pigmentary disturbance or mottling.
20 . A device for detecting one or more change in an eye, the device comprising:
a processor for comparing an image of the eye with at least one asynchronous image of the eye to thereby detect the one or more change in the eye wherein the change comprises a darkening or lightening in pigment of the Retinal Pigmented Epithelium (RPE) and/or macula occurring in either direction from one point in time to another point in time in the form of one or both of a pigmentary disturbance and mottling.
21 . The device of claim 20 , wherein when a change is detected by providing a diagnosis of, indication of or predisposition to an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto.