IP Library Granted Patent US 12685459
Granted Patent B2
US 12685459 · App. 18/010,923 · Granted Jul 21, 2026

Volatile organic compound capturing device

Inventor: Jay Eum (Irvine, CA)
Assignee: Spiracheck Limited
A61B5/097A61B5/082A61B5/742
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Quick Facts
Patent No.
US 12685459
App. No.
18/010,923
Granted
Jul 21, 2026
Kind
B2
Abstract

Disclosed herein include systems, devices, and methods for capturing compounds, such as volatile organic compounds, in gaseous samples onto capturing tubes, such as thermal desorption tubes, for subsequent analysis, such as disease diagnosis (e.g., cancer diagnosis).

Claims (88)

1 . A device for capturing one or more compounds in a gaseous sample comprising:

one or more device inlets for attaching one or more gaseous sample capturing tubes;

a device outlet;

an electric pump connected to the one or more device inlets for drawing a gaseous sample, or a portion thereof, through the one or more device inlets and expelling the content of the gaseous sample, or a portion thereof, through the device outlet;

one or more sensors connected to the device inlets, the electric pump, and/or the device outlet via one or more air tubes;

a user interface comprising a display;

non-transitory memory configured to store executable instructions; and

a microcontroller in communication with the electric pump, the one or more sensors, the user interface, and the non-transitory memory, the microcontroller programmed by the executable instructions to perform:

receiving a selected gaseous sample capturing flow rate and a selected gaseous sample capturing duration;

receiving an input to proceed; and

activating the electric pump to transfer the content in a gaseous sample collection bag, or a portion thereof, through the one or more gaseous sample capturing tubes, into the device via the one or more device inlets and out of the device via the device outlet, at the selected gaseous sample capturing flow rate for the selected gaseous sample capturing duration, thereby one or more compounds of the content in the gaseous sample collection bag, or a portion thereof, collected are captured onto the one or more gaseous sample capturing tubes,

wherein the microcontroller is further programmed by the executable instructions to perform:

causing the display to show a default gaseous sample capturing flow rate and a default gaseous sample capturing duration;

causing the display to show a message to attach one or more gaseous sample capturing tubes to the one or more device inlets and a gaseous sample collection bag;

causing the display to show a message requesting a gaseous sample to be collected through a bag inlet of the gaseous sample collection bag for a gaseous sample collection duration; and/or

showing on the display a countdown of the gaseous sample collection duration remaining, and

wherein the microcontroller is programmed by the executable instructions to perform:

activating the electric pump to transfer the content in the gaseous sample collection bag through the one or more gaseous sample capturing tubes;

receiving sensor information from the one or more sensors; and

showing on the display the sensor information, or a portion thereof.

2 . The device of claim 1 ,

wherein the gaseous sample comprises one or more volatile organic compounds (VOCs), thereby one or more of the VOCs of the content in the gaseous sample collection bag, or a portion thereof, collected are captured onto the one or more gaseous sample capturing tubes.

3 . The device of claim 1 , wherein:

(i) the gaseous sample comprises a breath sample of a subject, or the gaseous sample comprises an air sample; and/or

(ii) the device comprises: one or more valves in communication with the microcontroller, wherein each of the one or more valves in an opened state allows the gaseous sample to enter into the device via one or more of the one or more device inlets the valve controls, and wherein each of the one or more valves in a closed state prevents the gaseous sample from entering into the device via one or more of the one or more device inlets the valve controls.

4 . The device of claim 1 , wherein each of the one or more gaseous sample capturing tubes comprises a first tube opening, for attaching to one of the one or more device inlets, and a second tube opening, for attaching to a bag outlet of one or more bag outlets of the gaseous sample collection bag, optionally wherein one, or each, of the one or more bag outlets is perpendicular to the bag inlet.

5 . The device of claim 4 ,

wherein the gaseous sample collection bag comprises a bag body,

wherein the bag inlet comprises an inlet assembly comprising a threaded inlet pipe, an inlet sealing washer, and an inlet snap ring, wherein the threaded inlet pipe is attached to an inlet hole of the bag body by the inlet sealing washer and the inlet snap ring,

wherein each of the one or more bag outlets comprises an outlet assembly comprising a threaded outlet pipe, an outlet sealing washer, and an outlet snap ring, and wherein the threaded outlet pipe is attached to an outlet hole of the bag body by the outlet sealing washer and the outlet snap ring,

optionally wherein the inlet assembly comprises an inlet cap for preventing the gaseous sample to enter or exit the gaseous sample collection bag, and

optionally wherein the outlet assembly comprises an outlet cap for preventing the gaseous sample to enter or exit the gaseous sample collection bag.

6 . The device of claim 1 , wherein the one or more gaseous sample capturing tubes comprise one or more thermal desorption tubes.

7 . The device of claim 1 ,

wherein the microcontroller is programmed by the executable instructions to perform:

causing the display to show a message for any gaseous sample capturing tube attached to the one or more device inlets to be detached from the one or more device inlets;

receiving an input to proceed;

activating the electric pump at a purging flow rate for a purging duration; and

showing on the display a countdown of the purging duration remaining, and/or

wherein:

(i) the microcontroller is programmed by the executable instructions to perform:

generating sample identification information;

causing the display to show the sample identification information; and

receiving an input to proceed; or

(ii) the microcontroller is programmed by the executable instructions to perform:

causing the display to show a message requesting sample identification information; and

receiving the sample identification information.

8 . The device of claim 1 ,

wherein the microcontroller is programmed by the executable instructions to perform:

generating a linkage relationship of the sensor information and sample identification information;

storing the sensor information, or a portion thereof, the sample identification information, and/or the linkage relationship in the non-transitory memory and/or a removable memory; and/or

transmitting the sensor information, or a portion thereof, the sample identification information, and/or the linkage relationship to a computing device.

9 . The device of claim 1 ,

wherein the default gaseous sample capturing flow rate is about 5 ml/minute to about 2000 ml/minute,

wherein the selected gaseous sample capturing flow rate is about 5 ml/minute to about 2000 ml/minute,

wherein the purging flow rate is about 5 ml/minute to about 2000 ml/minute,

wherein the default gaseous sample capturing duration is about 1 minute to about 5 minutes,

wherein the selected gaseous sample capturing duration is about 1 minute to about 5 minutes, and/or

wherein the purging duration is about 10 seconds to 60 seconds.

10 . The device of claim 1 , wherein:

(i) the volume of the gaseous sample collected in the gaseous sample collection bag is about 2.5 liters, and/or wherein the volume of the gaseous sample collected in the gaseous sample collection bag that passes through the one or more gaseous sample capturing tubes is about 2 liters;

(ii) the gaseous sample collection duration is about 5 seconds to 20 seconds; and/or

(iii) the volume of gaseous sample collected in the gaseous sample collection bag during the gaseous sample collection duration is expected to be about 2.5 liters.

11 . The device of claim 3 , wherein the one or more valves comprise one or more solenoid valves.

12 . The device of claim 1 , wherein:

(i) one, or each of the one or more of the air tubes is rigid, semi-rigid, or elastic;

(ii) a material of one, or each, of the one or more air tubes is latex, rubber, silicone, or a combination thereof; and/or

(iii) sensors of the one or more sensors are connected sequentially.

13 . The device of claim 1 , wherein:

(i) each sensor of the one or more sensors, other than a sensor connected to the electric pump and a sensor connected to the device outlet, is connected to two sensors of the one or more sensors;

(ii) the one or more sensors comprises a flow rate sensor, a temperature sensor, a pressure sensor, a carbon dioxide (CO 2 ) sensor, a volatile organic compound (VOC) sensor, a humidity sensor, or a combination thereof; and/or

(iii) a sensor connected to the electric pump comprises a flow rate sensor.

14 . A method for capturing one or more compounds in a gaseous sample using the device of claim 1 .

15 . A method for capturing volatile organic compounds (VOCs) comprising:

programming a microcontroller with a set of executable instructions;

displaying a default volatile organic compound (VOC) capturing flow rate and a default VOC capturing duration;

receiving a selected VOC capturing flow rate and a selected VOC capturing duration;

displaying a message to attach one or more VOC capturing tubes to one or more device inlets of a device for capturing VOCs and a VOC collection bag;

receiving an input to proceed; and

activating an electric pump of the device to transfer the content in the VOC collection bag through the one or more VOC capturing tubes, into the device via the one or more device inlets and out of the device via a device outlet, at the selected collection flow rate for the selected capturing duration, thereby one or more VOCs of the content in the VOC collection bag are captured onto the one or more VOC capturing tubes,

wherein the microcontroller is programmed by the executable instructions to perform:

causing the display to show a message requesting a gaseous sample to be collected through a bag inlet of the VOC collection bag for a gaseous sample collection duration; and/or

showing on the display a countdown of the gaseous sample collection duration remaining, and

wherein the microcontroller is further programmed by the executable instructions to perform:

activating the electric pump to transfer the content in the VOC collection bag through the one or more VOC capturing tubes;

receiving sensor information from the one or more sensors; and

showing on the display the sensor information, or a portion thereof.

16 . The method of claim 15 , wherein the content of the VOC collection bag comprises a breath sample collected from a patient, or wherein the content of the VOC collection bag comprises an environmental VOC sample.