GLP-1R agonist and DPP-4 inhibitor compositions and methods of using
Disclosed herein are compositions comprising a GLP-1R agonist composition, a DPP-4 inhibitor composition, or a combination of both. The description contained herein describes methods for inducing weight loss and/or boosting satiety in a subject. The compositions described herein may be formulated for oral administration, and in some embodiments, may further comprise enteric or pH-responsive coatings.
1 . A granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip comprising a synergistic amount of Uva ursi extract and pterostilibene, wherein the ratio of the Uva ursi extract to the pterostilbene is 2.5:1 to 1:6.
2 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising a component selected from the group consisting of ginseng, curcumin, GLP-1, conjugated linoleic acid, bayberry powder, berberine, berberine hydrochloride, camellia sinensis, capsaicin, dong quai root powder, epigallocatechin gallate, freeze dried kefir milk, garcinia cambogia, hydroxycitric acid, lion's mane mushroom, medium chain triglycerides, quercetin, resveratrol, sucralose and combinations thereof.
3 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising ginseng.
4 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising curcumin.
5 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising a mixture of a ginseng and curcumin.
6 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising a component selected from the group consisting of climacostol, desoxyrhapontigenin, dihydropinosylvin monomethyl ether, dihydroresveratrol, gnetol, isorhapontigenin, isoresveratrol, oxyresveratrol, piceatannol, pinostilbene, pinosylvin, pinosylvin monomethyl ether, resveratrol, rhapontigenin, triacetylresveratrol, trimethylresveratrol, 3′-hydroxypterostilbene, 3,4′-dimethoxy resveratrol, 3,5-dihydroxy-4-ethyl-trans-stilbene, 3,5-dihydroxy-4-isopropylstilbene, 4′-bromo-resveratrol, 4,4′-dihydroxystilbene, allocryptopine, berberine, canadine, columbamine, coptisine, cordylamine, corysamine, cryptopine, cyclanoline, dihydroberberine, dihydrocoptisine, dihydropalmatine, epiberberine, groenlandicine, jatrorrhizine, methyl stepholidine, palmatine, protopine, pseudoberberine, pseudocoptisine, scoulerine, stepharanine, stepholidine, stylopine, tetrahydroberberine, tetrahydropalmatine and combinations thereof.
7 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising a component selected from the group consisting of resveratrol, berberine and combinations thereof.
8 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , further comprising a component selected from the group consisting of ginseng, curcumin, resveratrol, berberine and combinations thereof.
9 . The granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip of claim 1 , wherein the granule, soft capsule, hard capsule, gel capsule, plant based capsule, sachet, pill, tablet, caplet, gum, or dissolvable oral strip comprises a pH-responsive or enteric coating.