IP Library › Granted Patent US 12685726
Granted Patent B2
US 12685726 · App. 18/540,502 · Granted Jul 21, 2026

Sulfoximines as inhibitors of NaV1.8

Inventors: Marcel Muelbaier (Aachen, DE); Sebastian Krueger (Aachen, DE); Clemens Dialer (Aachen, DE); Mauro Marigo (Aachen, DE); Vipulkumar Patel (Aachen, DE)
Assignee: Gruenenthal GmbH
A61K31/44A61K31/415A61P29/00
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Quick Facts
Patent No.
US 12685726
App. No.
18/540,502
Granted
Jul 21, 2026
Kind
B2
Abstract

Compounds according to general formula (I) act as inhibitors of Na V 1.8 and can be used in the treatment of pain.

Claims (201)

1 . A compound according to formula (I):

wherein

one of A1, A2 and A3 represents C—R3 and another two of A1, A2 and A3 independently from one another represent CR′ or N;

R′ independently represents H, F, CH 3 , CH 2 F, CHF 2 , CF 3 , or OCH 3 ;

L represents CH 2 , CH(CH 3 ) or CH(CH 2 CH 3 );

R1 represents C 3-10 -cycloalkyl, 4 to 11-membered bicycloalkyl, 5 to 11-membered spiroalkyl or dispiroalkyl, 4 to 10-membered heterocycloalkyl, or 5 to 11-membered heterobicycloalkyl;

R2 represents H or C 1-6 -alkyl;

R3 represents S(O)(NR3a)R3b or S(NR3a) 2 R3b;

R3a represents H, C 1-6 -alkyl, C(O)C 1-5 -alkyl, C(O)C 1-5 -alkyl-NH 2 , C(O)C 1-5 -alkyl-NH—CH 3 , C(O)C 1-5 -alkyl-N(CH 3 ) 2 , C 3-10 -cycloalkyl, C 1-6 -alkylene-C 3-10 -cycloalkyl, 4 to 10-membered heterocycloalkyl, or C 1-6 -alkylene-(4 to 10-membered heterocycloalkyl);

R3b represents NH 2 , C 1-6 -alkyl, C 3-10 -cycloalkyl, C 1-6 -alkylene-C 3-10 -cycloalkyl, 4 to 10-membered heterocycloalkyl, or C 1-6 -alkylene-(4 to 10-membered heterocycloalkyl);

or R3a and R3b mean (CH 2 ) 3-5 and together with the atoms to which they are attached form a ring;

R4 represents H, F, Cl, Br, CN, CHF 2 , CH 2 F, CF 3 , C 1-6 -alkyl, C 3-10 -cycloalkyl, C 1-6 -alkylene-C 3-10 -cycloalkyl, 4 to 11-membered bicycloalkyl, 5 to 11-membered spiroalkyl or bisspiroalkyl, 4 to 10-membered heterocycloalkyl, C 1-6 -alkylene-(4 to 10-membered heterocycloalkyl), NH 2 , N(H)(C 1-6 -alkyl), N(C 1-6 -alkyl) 2 , O—C 1-6 -alkyl, O—C 3-10 -cycloalkyl, O—C 1-6 -alkylene-C 3-10 -cycloalkyl, O-(4 to 6-membered heterocycloalkyl), or O—C 1-6 -alkylene-(4 to 6-membered heterocycloalkyl);

R5 represents H, F, Cl, Br, CN, CHF 2 , CH 2 F, CF 3 , C 1-6 -alkyl, C 3-10 -cycloalkyl, C 1-6 -alkylene-C 3-10 -cycloalkyl, 4 to 10-membered heterocycloalkyl, C 1-6 -alkylene-(4 to 10-membered heterocycloalkyl), NH 2 , N(H)(C 1-6 -alkyl), N(C 1-6 -alkyl) 2 , O—C 1-6 -alkyl, O—C 3-10 -cycloalkyl, O—C 1-6 -alkylene-C 3-10 -cycloalkyl, O-(4 to 6-membered heterocycloalkyl), or O—C 1-6 -alkylene-(4 to 6-membered heterocycloalkyl);

wherein C 1-6 -alkyl and C 1-6 -alkylene in each case independently from one another is linear or branched;

wherein C 1-6 -alkyl, C 1-6 -alkylene, C 3-10 -cycloalkyl, 4 to 11-membered bicycloalkyl, 5 to 11-membered spiroalkyl or dispiroalkyl, 4 to 10-membered heterocycloalkyl, 4 to 6-membered heterocycloalkyl, and 5 to 11-membered heterobicycloalkyl in each case independently from one another are unsubstituted or substituted with one, two, three, four or more substituents independently from one another selected from the group consisting of F, Cl, CN, C 1-6 -alkyl, C 1-6 -alkylene-OH, C 1-6 -alkylene-OCH 3 , CF 3 , CF 2 H, CFH 2 , C(O)—C 1-6 -alkyl, OH, ═O, OCF 3 , OCF 2 H, OCFH 2 , O—C 1-6 -alkyl, C 1-4 -alkylene-O—C 1-4 -alkylene-O—CH 3 , C 0-4 -alkylene-O—(C 1-4 -alkylene-O) 1-4 —CH 3 , NH 2 , NH—C 1-6 -alkyl, N(C 1-6 -alkyl) 2 , or 4 to 6-membered heterocycloalkyl;

in the form of a free compound or a physiologically acceptable salt thereof.

2 . The compound according to claim 1 , wherein

(i) A1 represents C—R3, A2 represents N, and A3 represents CH;

(ii) A1 represents C—R3, A2 represents CH, and A3 represents CH; or

(iii) A1 represents C—R3, A2 represents N, and A3 represents N; or

(iv) A1 represents C—R3, A2 represents CH, and A3 represents N; or

(v) A1 represents CH, A2 represents C—R3, and A3 represent CH; or

(vi) A1 represents N, A2 represents C—R3, and A3 represent CH; or

(vii) A1 represents N, A2 represents C—R3, and A3 represent N.

3 . The compound according to claim 1 , wherein L represents CH 2 .

4 . The compound according to claim 1 , wherein R1 represents

C 3-10 -cycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ;

4 to 11-membered bicycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ;

5 to 11-membered spiroalkyl or dispiroalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ;

4 to 10-membered heterocycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ; or

5 to 11-membered heterobicycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 .

5 . The compound according to claim 4 , wherein R1 represents

cyclopropyl, methyl cyclopropyl, dimethyl cyclopropyl, fluoro cyclopropyl, difluoro cyclopropyl, trifluoromethyl cyclopropyl, trifluoromethyl methyl cyclopropyl, methyl difluoro cyclopropyl, trifluoromethyl difluoro cyclopropyl, dimethyl difluoro cyclopropyl, cyclobutyl, methyl cyclobutyl, dimethyl cyclobutyl, fluoro cyclobutyl, difluoro cyclobutyl, trifluoromethyl cyclobutyl, trifluoromethyl methyl cyclobutyl, methyl difluoro cyclobutyl, trifluoromethyl difluoro cyclobutyl, dimethyl difluoro cyclobutyl, cyclopentyl, methyl cyclopentyl, dimethyl cyclopentyl, fluoro cyclopentyl, difluoro cyclopentyl, trifluoromethyl cyclopentyl, trifluoromethyl methyl cyclopentyl, methyl difluoro cyclopentyl, trifluoromethyl difluoro cyclopentyl, dimethyl difluoro cyclopentyl, cyclohexyl, methyl cyclohexyl, dimethyl cyclohexyl, fluoro cyclohexyl, difluoro cyclohexyl, trifluoromethyl cyclohexyl, trifluoromethyl methyl cyclohexyl, methyl difluoro cyclohexyl, trifluoromethyl difluoro cyclohexyl, dimethyl difluoro cyclohexyl, cycloheptyl, methyl cycloheptyl, dimethyl cycloheptyl, fluoro cycloheptyl, difluoro cycloheptyl, trifluoromethyl cycloheptyl, trifluoromethyl methyl cycloheptyl, methyl difluoro cycloheptyl, trifluoromethyl difluoro cycloheptyl, dimethyl difluoro cycloheptyl, cyclooctyl, methyl cyclooctyl, dimethyl cyclooctyl, fluoro cyclooctyl, difluoro cyclooctyl, trifluoromethyl cyclooctyl, trifluoromethyl methyl cyclooctyl, methyl difluoro cyclooctyl, trifluoromethyl difluoro cyclooctyl, dimethyl difluoro cyclooctyl, cyclononyl, methyl cyclononyl, dimethyl cyclononyl, fluoro cyclononyl, difluoro cyclononyl, trifluoromethyl cyclononyl, trifluoromethyl methyl cyclononyl, methyl difluoro cyclononyl, trifluoromethyl difluoro cyclononyl, dimethyl difluoro cyclononyl, cyclodecyl, methyl cyclodecyl, dimethyl cyclodecyl, fluoro cyclodecyl, difluoro cyclodecyl, trifluoromethyl cyclodecyl, trifluoromethyl methyl cyclodecyl, methyl difluoro cyclodecyl, trifluoromethyl difluoro cyclodecyl, or dimethyl difluoro cyclodecyl; or

bicylo[1.1.1]pentyl, methyl bicylo[1.1.1]pentyl, methoxy bicylo[1.1.1]pentyl, difluoromethyl bicylo[1.1.1]pentyl, trifluoromethyl bicylo[1.1.1]pentyl, fluoro bicylo[1.1.1]pentyl, difluoro bicylo[1.1.1]pentyl, methyl difluoro bicylo[1.1.1]pentyl, trifluoromethyl difluoro bicylo[1.1.1]pentyl, bicyclo[2.1.0]pentyl, methyl bicyclo[2.1.0]pentyl, trifluoromethyl bicyclo[2.1.0]pentyl, fluoro bicyclo[2.1.0]pentyl, difluoro bicyclo[2.1.0]pentyl, methyl difluoro bicyclo[2.1.0]pentyl, trifluoromethyl difluoro bicyclo[2.1.0]pentyl, bicyclo[3.1.0]hexyl, methyl bicyclo[3.1.0]hexyl, trifluoromethyl bicyclo[3.1.0]hexyl, fluoro bicyclo[3.1.0]hexyl, difluoro bicyclo[3.1.0]hexyl, methyl difluoro bicyclo[3.1.0]hexyl, trifluoromethyl difluoro bicyclo[3.1.0]hexyl, bicyclo[2.2.0]hexyl, methyl bicyclo[2.2.0]hexyl, trifluoromethyl bicyclo[2.2.0]hexyl, fluoro bicyclo[2.2.0]hexyl, difluoro bicyclo[2.2.0]hexyl, methyl difluoro bicyclo[2.2.0]hexyl, trifluoromethyl difluoro bicyclo[2.2.0]hexyl, bicyclo[2.1.1]hexyl, methyl bicyclo[2.1.1]hexyl, trifluoromethyl bicyclo[2.1.1]hexyl, fluoro bicyclo[2.1.1]hexyl, difluoro bicyclo[2.1.1]hexyl, fluoro bicyclo[2.1.1]hexyl, difluoro bicyclo[2.1.1]hexyl, methyl difluoro bicyclo[2.1.1]hexyl, trifluoromethyl difluoro bicyclo[2.1.1]hexyl, bicyclo[4.1.0]heptyl, methyl bicyclo[4.1.0]heptyl, trifluoromethyl bicyclo[4.1.0]heptyl, fluoro bicyclo[4.1.0]heptyl, difluoro bicyclo[4.1.0]heptyl, methyl difluoro bicyclo[4.1.0]heptyl, trifluoromethyl difluoro bicyclo[4.1.0]heptyl, bicyclo[2.2.1]heptyl, methyl bicyclo[2.2.1]heptyl, trifluoromethyl bicyclo[2.2.1]heptyl, fluoro bicyclo[2.2.1]heptyl, difluoro bicyclo[2.2.1]heptyl, methyl difluoro bicyclo[2.2.1]heptyl, trifluoromethyl difluoro bicyclo[2.2.1]heptyl, bicyclo[3.3.0]octyl, methyl bicyclo[3.3.0]octyl, trifluoromethyl bicyclo[3.3.0]octyl, fluoro bicyclo[3.3.0]octyl, difluoro bicyclo[3.3.0]octyl, methyl difluoro bicyclo[3.3.0]octyl, or trifluoromethyl difluoro bicyclo[3.3.0]octyl; or

spiro[2.2]pentyl, methyl spiro[2.2]pentyl, fluoro spiro[2.2]pentyl, difluoro spiro[2.2]pentyl, methyl difluoro spiro[2.2]pentyl, spiro[2.3]hexyl, methyl spiro[2.3]hexyl, fluoro spiro[2.3]hexyl, difluoro spiro[2.3]hexyl, methyl difluoro spiro[2.3]hexyl, spiro[3.3]heptyl, methyl spiro[3.3]heptyl, fluoro spiro[3.3]heptyl, difluoro spiro[3.3]heptyl, methyl difluoro spiro[3.3]heptyl, or dispiro[2.0.2.1]heptyl; or

oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, morpholinyl, thiomorpholinyl, tetrahydrothiopyranyl, tetrahydrothiopyranyl 1,1-dioxide, oxepanyl, piperidinyl, piperidinonyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, 4-methylpiperazinyl, morpholinonyl, dioxanyl, piperazinyl, tetrahydropyrrolyl, azepanyl, dioxepanyl, oxazepanyl, diazepanyl, thiazolidinyl, tetrahydrothiophenyl, tetrahydropyridinyl, dithiolanyl, dihydropyrrolyl, dioxolanyl, dihydropyridinyl, dihydrofuranyl, dihydroisoxazolyl, dihydrooxazolyl, imidazolidinyl, isoxazolidinyl, oxazolidinyl, piperazinyl, N-methylpyridinonyl, pyrazolidinyl, pyranyl; dihydroquinolinyl, dihydroisoquinolinyl, dihydroindolinyl, dihydroisoindolyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl or tetrahydroindolinyl;

or 2-oxa-bicyclo[2.1.1]hexyl or methyl 2-oxa-bicyclo[2.1.1]hexyl.

6 . The compound according to claim 5 , wherein R1 represents

cyclopropyl, dimethyl cyclopropyl, trifluoromethyl methyl cyclopropyl, cyclobutyl, trifluoromethyl cyclobutyl, methyl trifluoromethyl cyclobutyl, difluoro cyclobutyl, methyl difluoro cyclobutyl, cyclopentyl, difluoro cyclopentyl, methyl difluoro cyclopentyl, trifluoromethyl cyclopentyl, trifluoromethyl difluoro cyclopentyl, cyclohexyl, difluoro cyclohexyl, or methyl difluoro cyclohexyl; or

bicylo[1.1.1]pentyl, trifluoromethyl-bicylo[1.1.1]pentyl, bicyclo[2.1.0]pentyl, difluoro bicyclo[2.1.0]pentyl, bicyclo[3.1.0]hexyl, difluoro bicyclo[3.1.0]hexyl, methyl difluoro bicyclo[3.1.0]hexyl, trifluoromethyl difluoro bicyclo[3.1.0]hexyl, bicyclo[2.2.0]hexyl, methyl bicyclo[2.2.0]hexyl, bicyclo[2.1.1]hexyl, fluoro bicyclo[2.1.1]hexyl, difluoro bicyclo[2.1.1]hexyl, bicyclo[4.1.0]heptyl, difluoro bicyclo[4.1.0]heptyl, bicyclo[2.2.1]heptyl, fluoro bicyclo[2.2.1]heptyl, bicyclo[3.3.0]octyl, or fluoro bicyclo[3.3.0]octyl; or

spiro[2.2]pentyl, difluoro spiro[2.2]pentyl, spiro[2.3]hexyl, methyl spiro[2.3]hexyl, fluoro spiro[2.3]hexyl, methyl difluoro spiro[2.3]hexyl, spiro[3.3]heptyl, or dispiro[2.0.2.1]heptyl.

7 . The compound according to claim 1 , wherein R2 represents H.

8 . The compound according to claim 1 , wherein R3a represents H, C 1-6 -alkyl, C(O)C 1-5 -alkyl, C(O)C 1-5 -alkyl-NH 2 , C(O)C 1-5 -alkyl-NH—CH 3 , C(O)C 1-5 -alkyl-N(CH 3 ) 2 .

9 . The compound according to claim 8 , wherein R3a represents H, CH 3 , C(O)CH 3 or C(O)CH 2 NHCH 3 .

10 . The compound according to claim 1 , wherein R3b represents NH 2 , C 1-6 -alkyl or C 3-10 -cycloalkyl.

11 . The compound according to claim 10 , wherein R3b represents NH 2 , CH 3 , CH 2 CH 3 , or cyclopropyl.

12 . The compound according to claim 1 , wherein R3a and R3b mean (CH 2 ) 3 and together with the atoms to which they are attached form a ring.

13 . The compound according to claim 1 , wherein R4 represents

C 1-6 -alkyl;

C 3-10 -cycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ;

4 to 11-membered bicycloalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ;

5 to 11-membered spiroalkyl, unsubstituted or substituted with one, two, three, four, or more substituents independently from one another selected from F, CH 3 , OCH 3 , CN, CHF 2 and CF 3 ; or

O—C 1-6 -alkyl, unsubstituted or substituted with one, two, three, four, or more F.

14 . The compound according to claim 13 , wherein R4 represents

CHF 2 , CH 2 F, CF 3 , CH 2 CHF 2 , CH 2 CH 2 F, CH 2 CF 3 , CF 2 CH 3 , CHFCH 3 , CF 2 CF 3 , CHFCF 3 , CH(CHF 2 )(CH 3 ), CH(CH 2 F)(CH 3 ), CH(CF 3 )(CH 3 ), CH 3 , CH 2 CH 3 , or CH(CH 3 ) 2 , or

cyclopropyl, methyl cyclopropyl, difluoromethyl cyclopropyl, trifluoromethyl cyclopropyl, cyano cyclopropyl, methoxy cyclopropyl, fluoro cyclopropyl, difluoro cyclopropyl, trifluoro cyclopropyl, cyclobutyl, methyl cyclobutyl, difluoromethyl cyclobutyl, trifluoromethyl cyclobutyl, cyano cyclobutyl, methoxy cyclobutyl, fluoro cyclobutyl, difluoro cyclobutyl, trifluoro cyclobutyl, cyclopentyl, methyl cyclopentyl, difluoromethyl cyclopentyl, trifluoromethyl cyclopentyl, cyano cyclopentyl, methoxy cyclopentyl, fluoro cyclopentyl, difluoro cyclopentyl, trifluoro cyclopentyl, cyclohexyl, methyl cyclohexyl, difluoromethyl cyclohexyl, trifluoromethyl cyclohexyl, cyano cyclohexyl, methoxy cyclohexyl, fluoro cyclohexyl, difluoro cyclohexyl, or trifluoro cyclohexyl; or

bicyclo[1.1.1]pentyl; or

spiro[2.2]pentyl or spiro[2.3]hexyl; or

O—CHF 2 , O—CH 2 F, O—CF 3 , O—CH 2 CHF 2 , O—CH 2 CH 2 F, O—CH 2 CF 3 , O—CF 2 CH 3 , O—CHFCH 3 , O—CF 2 CF 3 , O—CHFCF 3 , O—CH 3 , O—CH 2 CH 3 , or O—CH(CH 3 ) 2 .

15 . The compound according to claim 14 , wherein R4 represents

CF 2 CH 3 ; or

cyclopropyl, methyl cyclopropyl, difluoromethyl cyclopropyl, trifluoromethyl cyclopropyl, cyano cyclopropyl, methoxy cyclopropyl, fluoro cyclopropyl, difluoro cyclopropyl, trifluoro cyclopropyl, cyclobutyl, difluoro cyclobutyl, cyclopentyl, or difluoro cyclopentyl; or

O—CHF 2 .

16 . The compound according to claim 1 , wherein R5 represents C 1-6 -alkyl or Cl.

17 . The compound according to claim 16 , wherein R5 represents CHF 2 , CH 2 F, CF 3 , CH 2 CHF 2 , CH 2 CH 2 F, CH 2 CF 3 , CF 2 CH 3 , CHFCH 3 , CF 2 CF 3 , CHFCF 3 , CH(CHF 2 )(CH 3 ), CH(CH 2 F)(CH 3 ), CH(CF 3 )(CH 3 ), CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , or Cl.

18 . The compound according to claim 17 , wherein R5 represents CF 3 , CHF 2 , CH 3 , or Cl.

19 . The compound according to claim 1 , which is selected from the group consisting of:

1 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

3 1-((3,3-difluorocyclobutyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

4 1-((3,3-difluorocyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

5 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

7 3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

9 1-((4,4-difluorocyclohexyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

11 1-((4,4-difluoro-1-methylcyclohexyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

13 3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-((2-(trifluoromethyl)cyclobutyl)methyl)-1H-pyrazole-5-carboxamide;

15 3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-((3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methyl)-1H-pyrazole-5-carboxamide;

17 3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

21 3-cyclopropyl-1-((2-fluorospiro[3.3]heptan-2-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

23 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1-((3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)methyl)-1H-pyrazole-5-carboxamide;

25 3-cyclopropyl-1-((3-fluorobicyclo[1.1.1]pentan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

27 3-cyclopropyl-1-((6,6-difluorospiro[3.3]heptan-2-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

29 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclopentyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

31 3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-((3-(trifluoromethyl)cyclobutyl)methyl)-1H-pyrazole-5-carboxamide;

33 1-((3,3-difluorocyclopentyl)methyl)-3-(difluoromethoxy)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

34 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(N, S-dimethylsulfonimidoyl)pyridin-4-yl)-4-methyl-1H-pyrazole-5-carboxamide;

36 3-cyclopropyl-1-((3,3-difluorocyclopentyl)methyl)-N-(2-(N,S-dimethylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

44 1-((4,4-difluoro-1,2-dimethylcyclopentyl)methyl)-3-(1,1-difluoroethyl)-4-methyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

45 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

46 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(5-(S-methylsulfonimidoyl)pyridin-3-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

47 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(6-(S-methylsulfonimidoyl)pyridazin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

48 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(ethylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

49 N-(2-(cyclopropanesulfonimidoyl)pyridin-4-yl)-3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

50 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-methyl-6-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

51 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(1-oxido-4,5-dihydro-3H-11λ 6 -isothiazol-1-yl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

52 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-sulfamidimidoylphenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

53 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(methyl(phenyl)-26-sulfanediimine))-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

54 N-(3-(N-acetyl-S-methylsulfonimidoyl)phenyl)-3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

55 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(S-methyl-N-(methylglycyl)sulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

56 3-cyclobutyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

57 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3,3-difluorocyclobutyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

58 3-(bicyclo[1.1.1]pentan-1-yl)-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

59 3-cyclopentyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

60 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3,3-difluorocyclopentyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

61 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-3-(spiro[2.3]hexan-5-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

62 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2-fluorocyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

63 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,2-difluorocyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

64 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-3-(spiro[2.2]pentan-1-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

65 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2-methylcyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

66 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2-(difluoromethyl)cyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

67 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-3-(2-(trifluoromethyl)cyclopropyl)-1H-pyrazole-5-carboxamide;

68 3-(1-cyanocyclopropyl)-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

69 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-methylcyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

70 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-fluorocyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

71 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-methoxycyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

72 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,3-difluorocyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

73 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-3-(1,2,2-trifluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

74 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1,2-difluorocyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

75 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

76 4-chloro-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1,1-difluoroethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

77 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

78 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-(spiro[2.2]pentan-1-ylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

79 3-cyclopropyl-1-((2,2-difluorospiro[2.2]pentan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

80 3-cyclopropyl-1-(dispiro[2.0.2 4 .1 3 ]heptan-7-ylmethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

81 3-cyclopropyl-1-((1,2-dimethylcyclopropyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

82 3-cyclopropyl-1-((1-methyl-2-(trifluoromethyl)cyclopropyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

83 1-(bicyclo[2.1.0]pentan-1-ylmethyl)-3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

84 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-(spiro[2.3]hexan-5-ylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

85 3-cyclopropyl-1-((5-methylspiro[2.3]hexan-5-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

86 3-cyclopropyl-1-((1-methyl-3-(trifluoromethyl)cyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

87 3-cyclopropyl-1-((1-fluorospiro[2.3]hexan-5-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

88 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1-((3-(trifluoromethyl)cyclobutyl)methyl)-1H-pyrazole-5-carboxamide;

89 3-cyclopropyl-1-((3,3-difluorocyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

90 3-cyclopropyl-1-((5,5-difluorobicyclo[2.1.0]pentan-2-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

91 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-(spiro[2.3]hexan-4-ylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

92 3-cyclopropyl-1-((6,6-difluoro-4-methylspiro[2.3]hexan-4-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

93 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1-(spiro[3.3]heptan-1-ylmethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

94 3-cyclopropyl-1-((2-methylbicyclo[2.2.0]hexan-2-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

95 3-cyclopropyl-1-((3,3-difluorobicyclo[3.1.0]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

96 3-cyclopropyl-1-((4,4-difluorobicyclo[3.1.0]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

97 3-cyclopropyl-1-((5-fluorooctahydropentalen-2-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

98 3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1-((1-(trifluoromethyl)cyclopentyl)methyl)-1H-pyrazole-5-carboxamide;

99 3-cyclopropyl-1-((4,4-difluoro-2-methylcyclopentyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

100 3-cyclopropyl-1-((4,4-difluoro-2-(trifluoromethyl)cyclopentyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

101 3-cyclopropyl-1-((3,3-difluoro-5-methylbicyclo[3.1.0]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

102 3-cyclopropyl-1-((3,3-difluoro-5-(trifluoromethyl)bicyclo[3.1.0]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

103 3-cyclopropyl-1-((2,2-difluorobicyclo[2.1.1]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

104 3-cyclopropyl-1-((3,3-difluorobicyclo[2.1.1]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

105 3-cyclopropyl-1-((4-fluorobicyclo[2.1.1]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

106 3-cyclopropyl-1-((4-fluorobicyclo[2.2.1]heptan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

107 3-cyclopropyl-1-((4,4-difluorobicyclo[4.1.0]heptan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

108 3-(bicyclo[1.1.1]pentan-1-yl)-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

109 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-fluorocyclopropyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

110 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

111 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

112 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

113 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N-(3-(S-methylsulfonimidoyl)phenyl)-1H-pyrazole-5-carboxamide;

114 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,2-difluorobicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

115 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,2-difluorobicyclo[1.1.1]pentan-1-yl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

116 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,2-difluorobicyclo[1.1.1]pentan-1-yl)-4-(difluoromethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

117 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2,2-difluorobicyclo[1.1.1]pentan-1-yl)-4-(difluoromethyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-1H-pyrazole-5-carboxamide;

118 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-3-(2,2,3-trifluorobicyclo[1.1.1]pentan-1-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

119 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-3-(2,2,3-trifluorobicyclo[1.1.1]pentan-1-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

120 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-3-(2,2,3-trifluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazole-5-carboxamide;

121 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-3-(2,2,3-trifluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazole-5-carboxamide;

122 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3-methoxybicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

123 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(3-methoxybicyclo[1.1.1]pentan-1-yl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

124 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-3-(3-methoxybicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

125 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-3-(3-methoxybicyclo[1.1.1]pentan-1-yl)-N-(3-(S-methylsulfonimidoyl)phenyl)-1H-pyrazole-5-carboxamide;

126 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(4-fluoro-3-(S-methylsulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

127 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-fluoro-5-(S-methylsulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

128 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-fluoro-5-(S-methylsulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

129 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-fluoro-3-(S-methylsulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

130 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(3-(S-(difluoromethyl)sulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

131 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-fluorocyclopropyl)-4-(trifluoromethyl)-N-(3-(S-(trifluoromethyl)sulfonimidoyl)phenyl)-1H-pyrazole-5-carboxamide;

132 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(4-fluoro-3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

133 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(4-fluoro-3-(S-methylsulfonimidoyl)phenyl)-3-(1-fluorocyclopropyl)-1H-pyrazole-5-carboxamide;

134 3-(1-fluorocyclopropyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1-((2-(trifluoromethyl)cyclopropyl)methyl)-1H-pyrazole-5-carboxamide;

135 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-3-(1-fluorocyclopropyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-1H-pyrazole-5-carboxamide;

136 3-cyclopropyl-1-((2,2-difluorospiro[2.3]hexan-1-yl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

137 3-(bicyclo[1.1.1]pentan-1-yl)-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-1H-pyrazole-5-carboxamide;

138 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(difluoromethyl)-N-(4-fluoro-3-(S-methylsulfonimidoyl)phenyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazole-5-carboxamide;

139 3-(bicyclo[1.1.1]pentan-1-yl)-1-((2-(difluoromethyl)cyclopropyl)methyl)-N-(3-(S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

141 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(4-fluoro-3-(S-methylsulfonimidoyl)phenyl)-3-(3-fluorobicyclo[1.1.1]pentan-1-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

143 3-(tert-butyl)-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

144 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-3-(1-(trifluoromethyl)cyclopropyl)-1H-pyrazole-5-carboxamide;

145 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-(difluoromethyl)cyclopropyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

146 3-(bicyclo[1.1.1]pentan-1-yl)-1-((2-(difluoromethyl)cyclopropyl)methyl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

147 3-(bicyclo[1.1.1]pentan-1-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1-(((trans)-2-(trifluoromethyl)cyclopropyl)methyl)-1H-pyrazole-5-carboxamide,

148 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(2-fluoropropan-2-yl)-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

150 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-fluorocyclopropyl)-N-(3-(S-methyl-N-(oxetane-3-carbonyl)sulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

151 1-((3,3-difluoro-1-methylcyclobutyl)methyl)-3-(1-fluorocyclopropyl)-N-(3-(N-(2-hydroxyacetyl)-S-methylsulfonimidoyl)phenyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; and

152 3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-N-(2-(N-(2,3-dihydroxypropyl)-S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

in the form of a free compound or a physiologically acceptable salt thereof.

20 . A pharmaceutical composition comprising an amount effective to treat pain of at least one compound according to claim 1 .

21 . A pharmaceutical dosage form comprising at least one compound according to claim 1 .

22 . A method of treating pain in a subject in need thereof comprising administering to the subject an effective amount therefor of a compound according to claim 1 .

23 . A compound which is selected from the group consisting of:

140 1-((2-acetyl-2-azaspiro[3.3]heptan-5-yl)methyl)-3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

142 N-(2-N-cyano-S-methylsulfonimidoyl)pyridin-4-yl)-3-cyclopropyl-1-((3,3-difluoro-1-methylcyclobutyl)methyl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide; and

153 1-((2-azaspiro[3.3]heptan-5-yl)methyl)-3-cyclopropyl-N-(2-(S-methylsulfonimidoyl)pyridin-4-yl)-4-(trifluoromethyl)-1H-pyrazole-5-carboxamide;

in the form of a free compound or a physiologically acceptable salt thereof.