Multi-functional cleaning and/or debridement composition
The present invention relates to a new multifunctional debridement and/or antifouling composition comprising H 2 O 2 at a final concentration of between 0.1-5% v/v, and a composite hydrogel formulation comprising poloxamers at a concentration of 10-40% w/v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and/or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.
1 . An antimicrobial and/or anti-inflammatory composition for cleaning and/or debriding a biological surface and/or a biomaterial surface in situ, consisting of
a. H 2 O 2 at a final concentration of between 0.1-5% v/v, and
b. a composite hydrogel formulation comprising poloxamers at a concentration of 10-40% w/v,
wherein the ratio of the concentration of component a to component b in the composition is 1:10; and
wherein the composition is liquid at a temperature of at the most 30° Celsius.
2 . A kit comprising a composition according to claim 1 , the kit further comprising
h. at least two containers comprising said components a. and b., respectively,
i. a syringe and a vial,
j. a connector device,
k. an applicator tip, and
l. an instruction leaflet.
3 . A kit according to claim 2 , further comprising
m. a mixing device and
n. a debridement tool.
4 . A kit comprising a composition according to claim 1 , wherein said two components a. and b. are provided in a two-chamber syringe.
5 . A process for removal of biofouling, biofilm and/or necrotic tissue from a biological surface and/or a biomaterial surface in situ comprising the step of applying a composition according to claim 1 to the surface.
6 . A method for the treatment and/or prevention of periimplantitis, gingivitis, mucositis, peri-implant mucositis, periodontitis, and/or chronic and/or infected dermal ulcers comprising the step of applying a composition according to claim 1 to the tissue to be treated.
7 . An antimicrobial and/or anti-inflammatory composition for cleaning and/or debriding a biological surface and/or a biomaterial surface in situ, consisting of
a. H 2 O 2 at a final concentration of between 0.1-5% v/v, and
b. a composite hydrogel formulation comprising poloxamers at a concentration of 10-40% w/v, and
c. microparticles having a mean particle diameter (D50) of 20-200 μm, wherein said microparticles are organic or inorganic;
wherein the ratio of the concentration of component a to component b in the composition is 1:10; and
wherein the composition is liquid at a temperature of at the most 30° Celsius.