Aqueous pharmaceutical composition containing fusion protein of serum albumin and growth hormone
An aqueous pharmaceutical composition containing 10-100 mg/mL of a fusion protein of human serum albumin and human growth hormone, 10-150 mg/mL of sucrose, 0.15-10 mg/mL of a nonionic surfactant, 0.5-12 mg/mL of a preservative, and 1-30 mM of a buffer is, and the pH of the composition is 5.0-8.0.
1 . An aqueous pharmaceutical composition, comprising:
a fusion protein of human serum albumin and human growth hormone as an active ingredient at a concentration of 50 mg/mL;
sucrose at a concentration of 75 mg/mL;
a nonionic surfactant at a concentration of 3 mg/mL;
an antiseptic agent at a concentration of 6 mg/mL; and
a buffering agent at a concentration of 10 mM,
wherein a pH is 7.0 to 7.4,
wherein
the nonionic surfactant is polyoxyethylene (160) polyoxypropylene (30) glycol,
the antiseptic agent is phenol,
the buffering agent is a phosphate buffering agent, and
the fusion protein has the amino acid sequence of SEQ ID NO:11.