Complex
An object is to provide a technique that improves the poor solubility of a compound of formula (1) in water and further suppresses the cytokine excessive release action and bone marrow toxicity of the compound of formula (1). This object is achieved by a complex comprising a modified polysaccharide containing a hydrophobic group, and a compound represented by formula (1).
1 . A solution comprising a complex comprising a modified polysaccharide containing a hydrophobic group, and Telratolimod, wherein the polysaccharide that forms the modified polysaccharide comprises pullulan, and the hydrophobic group comprises a hydrophobic group having a sterol skeleton.
2 . The solution according to claim 1 , wherein the modified polysaccharide has a weight average molecular weight of 5000 to 2,000,000.
3 . The solution according to claim 1 , wherein the complex is gel particles.
4 . The solution according to claim 3 , wherein Telratolimod is contained within the gel particles.
5 . The solution according to claim 1 , wherein the mass ratio of the modified polysaccharide to Telratolimod (mass of modified polysaccharide/mass of Telratolimod) is 2 to 20.
6 . The solution according to claim 1 , wherein the complex has a scattering intensity average particle size of 10 to 200 nm.
7 . The solution according to claim 1 , which is used in combination with an immune checkpoint inhibitor.