System for drug delivery
Embodiments relate to systems comprising Active Wearable Medical Device (AWMD) with an osmotic chamber containing or configured to receive an osmotic agent, a permeability module for fluid ingress, and a drug chamber holding a drug. A compressible piston, positioned between the chambers, moves longitudinally as a whole during operation. The compressible piston advances toward the drug chamber when a valve opens, enabling drug release through one or more outlets, and retracts when the valve closes, driven by osmotic pressure. A valve module regulates this flow. The system also comprises a fluid chamber containing fluid and a semipermeable membrane coupling it to the AWMD. A channel connected to the drug outlets delivers the drug externally.
1 . A system comprising:
a medical device that is not configured to be implanted in a body of a mammal, comprising:
a drug chamber comprising a drug;
a compressible piston located adjacent to the drug chamber and comprising a cross sectional area, a drug chamber-facing surface and an opposite surface; and
a valve to allow flow of the drug from the drug chamber to outside the medical device through one or more drug outlets;
wherein the compressible piston is configured to deform such that the drug chamber-facing surface moves toward the drug chamber when the valve is opened, and the opposite surface follows when the valve is closed, resulting in a net longitudinal displacement of the piston as a whole.
2 . The system of claim 1 , further comprising a fluid chamber containing a liquid.
3 . The system of claim 2 , wherein the fluid chamber comprises an expandable elastomeric bladder and a rigid reservoir.
4 . The system of claim 2 , wherein the fluid chamber comprises a Hydrogel hydrogel-containing reservoir.
5 . The system of claim 2 , wherein the fluid chamber comprises a microfluidic reservoir.
6 . The system of claim 2 , wherein the fluid chamber comprises an active operated chamber.
7 . The system of claim 2 , wherein the fluid chamber comprises a passive operated chamber.
8 . The system of claim 1 , further comprising a catheter configured to deliver the drug to a specific anatomical site.
9 . The system of claim 8 , wherein the catheter is configured for targeted administration of the drug.
10 . The system of claim 1 , further comprising an attachment component adapted to secure at least a portion of the system to the mammal during discharge of the drug.
11 . The system of claim 1 , wherein the drug chamber comprises a plurality of drug chambers.
12 . The system of claim 11 , wherein the system is configured for sequential or combined discharge from the plurality of drug chambers.
13 . The system of claim 8 , wherein the system comprises a real-time imaging and navigation guidance device.
14 . The system of claim 13 , wherein the real-time imaging and navigation guidance device is configured to aid placement of the catheter and monitor dispersion of the drug in real-time.
15 . The system of claim 10 , wherein the attachment component comprises an adhesive layer.
16 . The system of claim 10 , wherein the attachment component comprises one of a mechanical fastener, a wearable strap, a wearable band, and a skin micro-anchor.
17 . The system of claim 1 , further comprising a fluid chamber containing a liquid, wherein the fluid chamber is fluidically connected to a pump, a microfluidic channel, or a delivery port.
18 . The system of claim 1 , further comprising a fluid chamber containing a liquid, wherein the fluid chamber is fluidically connected to a pump.
19 . The system of claim 1 , wherein the valve comprises an electrically actuated valve operable by a motor.
20 . The system of claim 1 , further comprising one or more sensors configured to monitor at least one of temperature, electrical conductivity, or displacement of the compressible piston.