Method and device for medically treating nasal and throat conditions with cold plasma
A medical device for providing nonthermal plasma treatment to a patient by generating sufficient nonthermal plasma in the presence of the flow of an oxygen-free gas mixture that can quickly and safely treat infection or promote wound healing in the desired region wherein the device is flexible and easy to maneuver in difficult to access regions such as the nose, paranasal sinuses, throat, esophagus, and ears of a patient and wherein the device comprises an integrated vacuum/suction to capture reactive species that are generated by plasma to prevent the patient from inhaling harmful byproducts.
1 . A cold plasma device comprising:
a probe, said probe comprising a conductor wire extending from a proximal end to a distal end and having a tip at said distal end;
wherein the conductor wire comprises an insulating material along a length of the probe from the proximal end to the distal end with a portion of noninsulated material at each end of the conductor wire and wherein the tip comprises a conductive gallium alloy, said gallium alloy having a melting point of about 40° C.;
a first passage having a first opening adjacent to the tip and a second passage having a second opening adjacent to the tip, said first passage being a gas delivery line and said second passage being a suction line, said first passage and said second passage disposed on opposing sides of the probe with the probe positioned centrally and in line between the first passage and the second passage;
wherein the first opening and the second opening each are dimensioned to be noncircular, having a first dimension along a width and a second dimension along a length; and
a power source generating 10,000-45,000 V at a pulse of 0.1 μs to 1 s in duration applied at 100 Hz to 10,000 Hz.
2 . The cold plasma device of claim 1 wherein the power source generates 17,000-37,000 V pulses of 1-5 us in duration applied at 1,000 Hz.
3 . The cold plasma device of claim 1 wherein the probe is connected to a pressurized gas and a wiring harness, said wiring harness connected to a power source.
4 . The cold plasma device of claim 1 wherein the conductor wire is surrounded by an epoxy along a length of the probe from the proximal end to the distal end.
5 . The cold plasma device of claim 1 wherein the first passage and the second passage are attached to the probe by a means selected from the group consisting of: an outside portion of the probe, a recess within the probe, being comprised within the probe, and combinations thereof.
6 . The cold plasma device of claim 1 wherein the first passage is provided with nitrogen gas.
7 . The cold plasma device of claim 1 wherein the first passage is provided with a mixture of nitrogen gas and nitric oxide.
8 . The cold plasma device of claim 7 wherein the first passage is provided with a mixture of nitrogen gas and nitric oxide at a concentration of the nitric oxide of 5,000 ppm and a flow rate of between 0.01 standard liters per minute (SLPM) and 0.15 SLPM.
9 . The cold plasma device of claim 1 comprising:
a suction of between 0.1 SLPM and 10 SLPM of flow within the second passage; and
a flow of a combination of nitrogen gas and nitric oxide, said nitric oxide at between 1,000 ppm and 10,000 ppm, having a standard liter per minute flow of 0.01 SLPM to 0.15 SLPM.
10 . A method of treatment of tonsillitis comprising administering to a patient in need thereof an effective amount of cold plasma, said cold plasma administered by applying a quantity of cold plasma from a probe from a cold plasma device of claim 1 .
11 . The method of treatment of claim 10 wherein the cold plasma is administered by providing a flow of nitrogen gas to a tip of the probe.
12 . The method of treatment of claim 10 wherein the cold plasma is generated from a probe, said probe comprising:
a conductor wire extending from a proximal end to a distal end and having a tip at said distal end;
a first passage having a first opening adjacent to the tip and a second passage having a second opening adjacent to the tip; and
a power source generating 10,000-45,000 V at a pulse of 0.1 us to 1 s in duration applied at 100 Hz to 10,000 Hz.
13 . The method of treatment of claim 12 wherein the conductor wire comprises an insulating material along a length of the probe from the proximal end to the distal end with a portion of noninsulated material at each end of the conductor wire.
14 . The method of treatment of claim 13 wherein the probe is connected to a pressurized gas selected from the group consisting of: N 2 gas or N 2 gas mixed with nitric oxide; wherein said pressurized gas is configured to flow into the first passage; wherein the probe is connected a wiring harness, said wiring harness connected to a power source; and wherein the probe is defined to provide suction from the second opening adjacent to the tip and through the second passage.