Compounds and methods of preparing compounds S1P1 modulators
The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.
1 . A crystalline form of a compound having the formula of
or a pharmaceutically acceptable salt thereof, wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising one or more peaks at about 8.9±0.5 degrees 2θ, at about 9.4±0.5 degrees 2θ, 15.7±0.5 degrees 2θ, at about 17.7±0.5 degrees 2θ, at about 18.9±0.5 degrees 2θ, 24.3±0.5 degrees 2θ, at about 26.0±0.5 degrees 2θ, and at about 26.7±0.5 degrees 2θ.
2 . The crystalline Form I of claim 1 , or a pharmaceutically acceptable salt thereof, characterized by an X-ray powder diffraction pattern comprising one or more d-spacing values at about 10.0±0.5 degrees angstroms, at about 9.4±0.5 degrees angstroms, at about 5.6±0.5 degrees angstroms, at about 5.0±0.5 degrees angstroms, at about 4.7±0.5 degrees angstroms, at about 3.7±0.5 degrees angstroms, at about 3.4±0.5 degrees angstroms, and at about 3.3±0.5 degrees angstroms.
3 . A pharmaceutical composition comprising the crystalline form of claim 1 .
4 . A pharmaceutical composition comprising the crystalline form of claim 2 .