Procoagulant peptides and use thereof
There is provided procoagulant peptides, and use of same, such as in treatment of hemostasis-related diseases or disorders, and/or wound healing.
1 . A peptide consisting of the amino acid sequence GSKRRKLRVYLHCT (SEQ ID NO: 2), wherein the N-terminus is acetylated and the C-terminus is amidated.
2 . A pharmaceutical composition comprising the peptide of claim 1 , and a pharmaceutically acceptable carrier.
3 . A wound dressing comprising the peptide of claim 1 .
4 . A method for treating a subject in need of wound healing, the method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a procoagulant peptide consisting of the amino acid sequence GSKRRKLRVYLHCT (SEQ ID NO: 2), wherein the N-terminus is acetylated and the C-terminus is amidated, thereby treating the subject in need of wound healing.
5 . A method for treating a subject in need of induction of coagulation, the method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a procoagulant peptide consisting of the amino acid sequence GSKRRKLRVYLHCT (SEQ ID NO: 2), wherein the N-terminus is acetylated and the C-terminus is amidated, thereby treating the subject in need of induction of coagulation.
6 . The method of claim 5 , wherein said subject is afflicted with a wound, hemorrhage, or both.
7 . The method of claim 5 , wherein said subject is afflicted with a disease or a disorder being selected from the group consisting of: hemostatic disorder, anticoagulation disorder, angiogenesis-related disease, hemophilia, and any combination thereof.
8 . The method of claim 5 , wherein said administering comprises: subcutaneously administering, intravenously administering, topically administering, or any combination thereof.